How to Permanently reduce prolactin?

**msmoke44** · 11-21-2012, 08:38 PM

If one is having very high prolactin issues off cycle(not related to AAS), after full recovery. Then how do we reduce prolactin permanently? Obviously caber/prami is temporary relief and is to be used only on cycle for 8-16weeks etc and shouldnt be run for a problem not related to cycle. SO How do we rid of this curse? I'm only 21 years old and only ran var/prop. thanks

Currently running vit B6 at 400mg daily and vitex at 800mg daily and its only providing very slight relief, plus I stopped the vitex for a day and the rebound was instant horribly prolactin sky high

**MickeyKnox** · 11-21-2012, 08:40 PM

Edit: Misunderstood the question.

**Lunk1** · 11-21-2012, 08:45 PM

Some ppl run Caber year round. What is your BF%. You should have blood work done and see where your E2 is!

**msmoke44** · 11-21-2012, 08:57 PM

Estradiol was at <8. (been on letro for a while and tapering down)

**Sworder** · 11-21-2012, 10:26 PM

Have you been to a doctor in case of a tumor?

**msmoke44** · 11-22-2012, 01:28 PM

Originally Posted by Sworder

Have you been to a doctor in case of a tumor?

Not yet, my insurance is having some issues

**Sworder** · 11-22-2012, 01:41 PM

That should be your first course of action as it probably is a serious medical issue.

Good luck try to get the insurance problems resolved and do not self-medicate until you are examined by a medical doctor.

**ScotchGuard02** · 11-22-2012, 01:43 PM

I'm curious to know what kind of affects the high prolactin is having on you?

**msmoke44** · 11-22-2012, 03:46 PM

puffy and leaking nips. elevated anxiety(could be from low estro/high test though)

**JohnnnyBlazzze** · 11-22-2012, 04:12 PM

Have you ran a protocol with Letro and Caber/Prami combined?

Like others mentioned, I would get bloodwork done to check E2 and PRL levels before moving forward.

**msmoke44** · 11-22-2012, 09:01 PM

e2 is at less than 8

**kelkel** · 11-22-2012, 09:53 PM

Originally Posted by Sworder

Have you been to a doctor in case of a tumor?

This^^above all else. See a good doctor, get full BW and an MRI. Rule it in or out asap. In the meantime, don't panic, it's not the end of the world, trust me.

**broesb4hos** · 02-20-2013, 02:14 PM

Originally Posted by kelkel

This^^above all else. See a good doctor, get full BW and an MRI. Rule it in or out asap. In the meantime, don't panic, it's not the end of the world, trust me.

If it is a tumor then what is the next course of action? Will an operation to remove the tumor or use of bromo therapy to shrink the tumor to non existence cause the increased prolactin levels to go away permanently?
If it is not a tumor then what is the next course of action? Will taking cabergoline for an extended period of time (6-8 months) cause prolactin levels to go back to normal?

My last two most recent blood tests (both done in jan 2013) have shown that I have an increased level of prolactin that is slightly out of the normal range. I have been experiencing symptoms (ED, lack of libido, weak erection) of slightly elevated prolactin levels for 2 years now, though I have not been to the doctor to get a CT scan done yet because of my insurance situation. I used AAS when I was 21 and 23 but did not show any of the symptoms described earlier after using them at all. When I turned 25 is when I started to notice symptoms, so 2 years after my last AAS use.... I am going to turn 27 soon and I am still experiencing symptoms for 2 years now.... Is it possible that my prior AAS use caused this to happen even after 2 years of not using AAS and not having experienced symptoms before?

**clarky.** · 02-20-2013, 02:20 PM

Hope everything goes ok for you mate.

**rmbX66t1** · 02-20-2013, 02:27 PM

Running a dopamine agonist like prami or caber year round works fine; however, you have to keep in mind the potential mental trauma that can result from prolonged used of a dopamine agonist.

**AnabolicDoc** · 02-20-2013, 02:33 PM

In some ppl with micro-prolactinomas, a 6 month course of bromocriptine can cause long term suppression of prolactin secretion. If that doesn't work, or if you're not a candidate for bromo therapy, then there is a procedure called a transphenoidal resection of the tumor. Here is a link that describes the procedure:

http://www.mayfieldclinic.com/PE-EndoPitSurg.htm

They basically go through your nostrils with a long needle and thin camera (endoscope). It's done by brain surgeons (neurosurgeons) so I have no experience with this.

Regarding bromocriptine therapy, I'm not sure if that's still the first medical option or if there has been a transition to the use of cabergoline (or possibly pramipexole but I highly doubt it as is not FDA approved for the treatment of prolactinomas).

But see a doctor and get evaluated before you start worrying about all this stuff.

**kelkel** · 02-20-2013, 02:39 PM

Listen to the doc please. I have a pit tumor, just not a prolactinoma. You'll be fine. Rule it out!

**warmouth** · 02-20-2013, 02:55 PM

Originally Posted by AnabolicDoc

In some ppl with micro-prolactinomas, a 6 month course of bromocriptine can cause long term suppression of prolactin secretion. If that doesn't work, or if you're not a candidate for bromo therapy, then there is a procedure called a transphenoidal resection of the tumor. Here is a link that describes the procedure:

http://www.mayfieldclinic.com/PE-EndoPitSurg.htm

They basically go through your nostrils with a long needle and thin camera (endoscope). It's done by brain surgeons (neurosurgeons) so I have no experience with this.

Regarding bromocriptine therapy, I'm not sure if that's still the first medical option or if there has been a transition to the use of cabergoline (or possibly pramipexole but I highly doubt it as is not FDA approved for the treatment of prolactinomas).

But see a doctor and get evaluated before you start worrying about all this stuff.

Do you think that some of the advice here of running caber year around is beneficial, or is there any long term problems that can come from this? I would like to know for OPs sake as well as a friend who will not come off. Thanks doc for all of your input!

**rmbX66t1** · 02-20-2013, 03:42 PM

Originally Posted by warmouth

Do you think that some of the advice here of running caber year around is beneficial, or is there any long term problems that can come from this? I would like to know for OPs sake as well as a friend who will not come off. Thanks doc for all of your input!

I certainly would be weary of downregulation of dopamine D1-receptors, and developing dependency.

Fortunately, it isn't as bad as bromo for downregulation;

Dopamine D1 family
D1 (weak)
D5 (weak)
Dopamine D2 family
D2 (very strong)
D3 (strong)
D4 (strong)
Serotonin 5-HT
5-HT1 (moderate; all subtypes)
5-HT2 (moderate; all subtypes)

Or prami;

D2S receptor (Ki = 3.9 nM; IA = 130%)
D2L receptor (Ki = 2.2 nM; IA = 70%)
D3 receptor (Ki = 0.5 nM; IA = 70%)
D4 receptor (Ki = 5.1 nM; IA = 42%)

**AnabolicDoc** · 02-20-2013, 05:13 PM

Originally Posted by warmouth

Do you think that some of the advice here of running caber year around is beneficial, or is there any long term problems that can come from this? I would like to know for OPs sake as well as a friend who will not come off. Thanks doc for all of your input!

I don't know the answer to your question, but if you give me a few days I will look into it and ask some friends.