Myostatin Blockers

[The Bear 79]

OK, per Roman's advice / suggestion, (in another thread) I want to start a thread about Myostatin Blockers.

Now I know we aren't allowed to post sources so lets all heed that rule Gents. However, I would like this thread to be a place where we can collectively share any knowledge we may have on this relativity new concept.

Here we can learn more about how Myostatin in excess can adversely effect / inhibit muscle growth, & what we can do to control it, the pro's & cons of the blockers we to control it & also what we can do to counter act the side effects of these blockers.

You all were very responsive & helpful in the "Can long term use create an immunity" thread, & I look forward to working with all of you to determine a viable & safe solution to this evil little element of our body.

I will edit this post later to post my findings, facts & opinions thus far. Right now I'm hungry & I need a shower. In the meantime, please feel free to post any info you may have.

[Lunk1]

After reading TR's post I did a quick search and was unable to find any "real" myostatin blockers that are yet available through prescription or any other means. It appears that they are still in trials with drug companies from the best I could find. (mind you I spent very little time on it, just a quick google search).

[The Bear 79]

I haven't found anything in a Google search either, other than some speculation of Creatine being a Myostatin blocker, no concrete evidence on it though. But whenever something new hits "the market" that I'm interested in, I ask my sources if they have it or can get it, if anyone can get their hands on controlled substances, it would be your steroid source right???

[Sgt. Hartman]

A member here ran a log on follistatin

http://forums.steroid.com/showthread...=#.UMf9_fa9LCQ

[Lunk1]

A member here ran a log on follistatin

http://forums.steroid.com/showthread...=#.UMf9_fa9LCQ

Just read the log...nothing concrete imo!

[Sgt. Hartman]

Most say its worthless but who knows if it really isn't effective or just more bunk research peptides.

[Lunk1]

I'm guessing that it's been tested for sooo long because the sides far exceed the benifit!

[The Bear 79]

I'm having some trouble editing my original post for some reason, so I'll post my findings in a new post. Originally I was going to post each link individually, but its much easier to post this all inclusive link. I posted this link once before in another thread, it contains both study's & opinions. I have found a few more articles on the subject that I have briefly grazed through, after I read them thoroughly, if I find them useful, I'll post the link(s) Also, I'm currently in the process of digging up a solution to the side effects that are associated with the use of Myostatin blockers. I'll post what I find soon. Again, all feedback is welcome here.

[bigsiv]

There's not much info about myostatin blockers out there the only bit of info was some trials what took place but even these trials were not directly looking at muscular growth but do summarise that the field for this drug is open.....take a look:


http://www.ncbi.nlm.nih.gov/m/pubmed/18335515/

[bigsiv]

I should say the only bit of info I have found up to now, not the only bit of info out there DUH!

[bigsiv]

I'm guessing that it's been tested for sooo long because the sides far exceed the benifit!

The reports I have been reading suggested that this Myo-029 when tested on 116 people did not aid in muscle dystrophy even at 30mg, I think that's why it was discontinued. Not sure if you are talking about another myostatin inhibitor Lunk. I'm still getting my head around the effects of myostatin or even better the inhibition. Doubt any of my sources would have a clue lol (Not fishing by the way was JOKE)

[Lunk1]

The reports I have been reading suggested that this Myo-029 when tested on 116 people did not aid in muscle dystrophy even at 30mg, I think that's why it was discontinued. Not sure if you are talking about another myostatin inhibitor Lunk. I'm still getting my head around the effects of myostatin or even better the inhibition. Doubt any of my sources would have a clue lol (Not fishing by the way was JOKE)

No...I'm talking about some of the Myo blockers being tested by drug companies, read a bit about the fact that the high doses needed could result in things like cardiovascular problems and bone density issues.

I agree...I doubt too many AAS dealers would have a clue..

I understand tests are still being done by some research clinics on diff. myo blocker solutions. Hopefully they find a solution

[jimmyinkedup]

Great read on what myostatin is...and isnt.
http://www.jappl.org/content/103/5/1488.full
"We report herein that myostatin protein levels quantified in serum and muscle, along with muscle myostatin transcript levels, do little to determine individual responsiveness to a resistance training stimulus for muscle growth in adult humans'...."

[bigsiv]

No...I'm talking about some of the Myo blockers being tested by drug companies, read a bit about the fact that the high doses needed could result in things like cardiovascular problems and bone density issues.

I agree...I doubt too many AAS dealers would have a clue..

I understand tests are still being done by some research clinics on diff. myo blocker solutions. Hopefully they find a solution

Will keep looking Lunk still a bit new to me this one but looks like a dream drug if it can obtained and tested properly.

[Bonaparte]

There aren't any worth trying to obtain yet.

[Lunk1]

there aren't any worth trying to obtain yet.

yet!

[The Bear 79]

Great read on what myostatin is...and isnt.
http://www.jappl.org/content/103/5/1488.full
"We report herein that myostatin protein levels quantified in serum and muscle, along with muscle myostatin transcript levels, do little to determine individual responsiveness to a resistance training stimulus for muscle growth in adult humans'...."

Thank you Jimmy, great read indeed, very thorough, however, this study pretty well debunks the entire "Myostatin inhibits muscle growth" theory. So I guess I'm back to my original question..............."can long term use create an immunity"??

[Times Roman]

just a quick warning to hopefully prevent some from falling into the same trap i fell into. The MB's are apparently in clinical trials? (not sure). So even if this is true, and not available in america, there will be some overseas outfits that will claim to be able to bring you the raw powders. Don't get scammed like I did when I ordered up the 50 grams of GW501516. Be careful! you may be able to find a legit source, but there will be many right now selling bogus too.

[Andrewlazootin]

Myostatin blockers are now available in ampule form and are being released in oral capsule form on the 17th of January 2013. I did training in Switzerland in November on stem cell and protein treatments and one of the products they released was a myo blocker. Being the sceptic I am a bought some and have been using it for the past 9 weeks with great results.

[Lunk1]

Myostatin blockers are now available in ampule form and are being released in oral capsule form on the 17th of January 2013. I did training in Switzerland in November on stem cell and protein treatments and one of the products they released was a myo blocker. Being the sceptic I am a bought some and have been using it for the past 9 weeks with great results.

Do you have a name for the magic beans???

[OnTheSauce]

Please tell me

[qscgugcsq]

SENZU BEANS!!

I've read a bit on a myostatin ihnibitor and asked to a dude who worked on a clinical trial on people suffering of muscular dystrophy. He didn't worked with the ace-031 but all the experiment they did with myostatin inhibitor were really great. however the trial of the ace-031has been stopped for safety issue. I'm waiting for further research but up to now it really seems amazing. Look like magic stuff!!

http://quest.mda.org/news/ace-031-cl...md-stopped-now


Did you see the german kid (Goku at birth XD) born with a complete lack of myostatin??? If not check this:
http://www.msnbc.msn.com/id/52***28/...-tot-superboy/
(add 7 8 0 instead where their is ***)

[Andrewlazootin]

The child you refer to is now in his 20s and still has the same body without working out. Being new to this forum and any forum I didn't realize my name would come up. Oh well you have it now. The myo blocker has just been released after trials and has no side effects, is therefore better than roids and a lot safer. The dosage is 1ml three times the first week 1ml twice the second week and one ml there after for about ten weeks is recommended, and it's not horrendously expensive. One of the great benefits I've found is there is a reduction in muscular inflammation and ache after workouts. One other thing, I am 56 now and it works fine on me, you don't have to be young.
You are correct, we use it in clinic for clients with chronic disease to prevent muscular atrophy. If you want more info that I can't give you without breaking forum rules look me up. Fair well for now from the lad from down under.

[The Bear 79]

I am compelled to refer EVERYONE to the link (study) that Jimmy posted in post #13. I recommend everyone read the ENTIRE study, it's very informative & eye opening in reference to what this self produced compound (for lack of better term) is & does, & the potential side effects of blocking it's production. The following is a copy / paste from the study that I feel should be seen & understood by anyone that is full throttle & hell bent on jumping on myostatin blockers:

"In summary, it is abundantly clear from the literature that myostatin is perhaps the single most powerful negative regulator of muscle mass during mammalian development. Homozygous mutant animals (31) and humans (41) realize marked increases in both myofiber number and size early in the postnatal period, resulting in adult muscle masses considered extreme. Based on the early seminal findings in myostatin discovery and characterization, investigators have feverishly pursued myostatin blockade or inhibition as a potential therapeutic in adult conditions of muscle wasting or atrophy. We report herein that myostatin protein levels quantified in serum and muscle, along with muscle myostatin transcript levels, do little to determine individual responsiveness to a resistance training stimulus for muscle growth in adult humans, including a relatively large cohort of sarcopenic elderly."

[qscgugcsq]

Andrew I would like to talk to you but I can't send you any private msg. I think it's because you don't have enough post.
I would really appreciate to ask you some question, do you have another way to communicate?

[Andrewlazootin]

If you google me, I am well known in Australasia