Anavar is NOT a mild compound where HPTA suppression/shutdown is concerned!!

[Atomini]

I've been meaning to share this information with you all for a couple weeks now, but i've been pretty busy with the holidays and what not.

Anyhow, my personal research as well as my university studies have lead me to some interesting information on Anavar and its effects on HPTA suppression, and the real hard truth behind it. Anavar has always been touted as a very 'mild' compound. For the most part, it is. But too many people have for decades been using the world 'mild' to describe every effect and aspect of this compound. Anavar is NOT 'mild' in the realm of HPTA function, nor is it 'mild' in terms of its anabolic effects (it is actually quite the powerful anabolic steroid , perhaps more so than Anadrol in fact), however that's a story for another day. The focus of my quick post here is Anavar's effects on the HPTA since that is one of the most expounded descriptions of one of the areas Anavar is frequently said to be 'mild' in. Well, i'm here to tell you all that this is absolutely not the case. Anavar is just as suppressive as any anabolic steroid out there in existance.

In my program, shortly before the Christmas break, we actually covered Anavar!!! I was extremely excited (and surprised) to see that here in a pre-med university program, we're actually covering (albeit very briefly) an anabolic steroid and its effects on the endocrine system. As anyone familiar with life-sciences programs and med school programs knows, there is no such thing as an 'anabolic steroid' course or class. So I was pretty ecstatic, even though this was very brief. We covered some of its actions in muscle tissue and other tissues, we covered its medical applications and its beneficial results in patients suffering from trauma and its use as an osteoperosis medication. A guest speaker covered most of this with us, who is a former proffessor and is a current MD involved in research in the Division of Endocrinology and Metabolism. After everything was over, I had a chance to speak to him and ask him to share/exchange information concerning Anavar and such. Of course the guy is very busy and had only a half hour to spare with me, which I thought was very generous of him. So we discussed a whole ton of AAS-related topics, of which 30 minutes was just not enough time, and man was I blown away. But where Anavar is concerned, he told me quite a few eye-opening details, and provided me with a bunch of clinical studies to investigate for my own personal amusement.

It seems as though Anavar is commonly labelled by all of the gym bros for decades as 'mildly' suppressive to the HPTA, but there is only a sliver of truth to this. This seems to only be the case with the absolute lowest of medical prescription doses (such as 5mg daily administered to children). Bodybuilding doses, which is what we are all concerned with here, is a whole different ball game and in studies demonstrate very strong suppression of endogenous Testosterone production. The most prominent study I saw was one involving 6 young male test subjects that were administered Anavar had shown that after only 5 days of Anavar administration (at only 15mg/day), the Testosterone levels ofthese 6 subjects dropped DRASTICALLY by day 5 from 449ng/dl to 282ng/dl – a 37% reduction of Testosterone in just 5 days(1). That is a massive drop after such a small period of time at a dose that isn't even considered a 'bodybuilding' dose. If this is what Anavar does at 15mg daily after 5 days of use, ask yourself what bodybuilding doses (30mg MINIMUM daily of Anavar) for weeks will end up doing?


This is a graph from the study conducted. It demonstrates total androgen concentration showing total serum Testosterone (lined areas) and Oxandrolone (black areas) concentrations in five young men on days 0, 3, and 5, Testosterone decreased significantly from days 0 and 3 to day 5 (P < 0.05).

- The first point i'm making of this post is to show all of you newcomers and youngsters here who are under the age of 24 that Anavar is NOT a safe or 'mild' choice to engage in. It very well has the potential for the same amount of shutdown as a Testosterone cycle as far as I am concerned. So if you think that attempting an Anavar-only cycle for your first cycle is going to save you from any potential permanent HPTA problems later on in life, think again!

- The second point i'm making here is to show that Anavar-only cycles are destructive to the body without the inclusion of some form of Testosterone. Anavar necessitates the use of Testosterone in at least a TRT dose in order to maintain normal physiological function in the presence of a suppressed/shutdown HPTA as a result of Anavar use. Will you die if you do an Anavar-only cycle? No. But it's not optimal or healthy for the body, and can cause issues (both noticeable and un-noticeable) when your endogenous production of Testosterone bottoms out.

There exists no 'perfect anabolic steroid', but Anavar is perhaps the anabolic steroid that has come the closest to the 'perfect steroid' - but the point here it that is NOT 'perfect' by any means and still possesses its flaws.

REFERENCES:
1. Short-Term Oxandrolone Administration Stimulates Net Muscle Protein Synthesis in Young Men. Melinda Sheffield-Moore, Randall J. Urban, Steven E. Wolf, J. Jiang, Don H. Catlin, David N. Herndon, Robert R. Wolfe and Arny A. Ferrando. Sheffield-Moore et al. Journal of Clinical Endocrinology & Metabolism. August 1, 1999; 84 (8): 2705

[t-dogg]

Good read. Thats why I say to always run test with it. They work great together.

[Fllifter]

As always, very informative and a great post.

[Brick]

Wow. Another great post

[Soar]

Another good read ty

[kelkel]

Great post Atomini! I bet you were excited like a kid during that one on one.

[bigsiv]

Great post Atomini!

[Atomini]

Great post Atomini! I bet you were excited like a kid during that one on one.

Like a kid in a candy store. People were looking at me very strangely, like I had a toaster on my head. I was also the only one to approach the MD after the lectures lol.

[jrod04]

Great post! And very good to to know, thanx for sharing that info!

[Lunk1]

Great info...not that it's any surprise coming from you A.

No doubt this post will be referenced once or twice

[gymfu]

How are study's like this being done? Are you sure this study is good information?
Not being confrontational, I just thought that study's with AAS could be done because they are on the controlled substances list.

[OdinsOtherSon]

Thanks Atomini! Great info...really appreciate you taking the time to share!!

[beenie]

I believe that's why people combine Anavar with test.

[RoadToHuge]

Great info Atomini. I know anavar has a profound effect on me. The again I run it with test and tren . I really love those three together. Now if I could figure out how to get my appetite back I would be set!

[Lunk1]

I believe that's why people combine Anavar with test.

Have you not read any of the Q&A posts...friggin thing is full og Var ONLY cycles every week!

[Lunk1]

Great info Atomini. I know anavar has a profound effect on me. The again I run it with test and tren. I really love those three together. Now if I could figure out how to get my appetite back I would be set!

What is your test at per week?

[ElectraMaddox]

I love this thread!

[Atomini]

How are study's like this being done? Are you sure this study is good information?
Not being confrontational, I just thought that study's with AAS could be done because they are on the controlled substances list.

I believe you're misunderstood. The fact that these substances are on the controlled substances list do not prohibit medical, scientific, and scholarly educational institutions from conducting ethical studies into these substances (this also extends to those other recreational drugs that we cannot mention here on this forum).

To say that because a drug is a scheduled substance and therefore no institution is permitted to examine, analyze, and study it, is, to say the least, extremely hubris. And I am particularly VERY GLAD that the politicians have not stepped over the boundaries to restrict such a thing for such a disgusting reason.

Anabolic steroids have perhaps more use in medicine than do any other scheduled and controlled substances - and remember, the United States of America is THE ONLY country in the world (with the exception of France I think) that has criminalized personal use and possession of anabolic steroids . Canada is one such country where personal possession and use is legal (AAS here in Canada are a schedule IV drug as opposed to schedule III in the USA). So to say that it is a controlled substance in the United Statea and therefore not viable for study anywhere else in the world seems ridiculous to me. There have been hundreds of studies conducted on anabolic steroids both before their legislation in 1990, as well as afterwards. Of course, studies like these must be within the ethical boundaries, and they of course do not extend to substances that are NOT approved for human use (such as Trenbolone , for example) and of course this is the reason why Trenbolone has undergone almost no studies on human test subjects. Ethical boundaries of course also include issues of safety. So, some questions about AAS (or any drug for this matter) will never be answered because some studies cannot be ethically justified. An example of a study that would be ethically wrong would be one in which test subjects are administered insanely high doses of Testosterone (lets say 2 grams per week), which would increase the chances of injury to a great deal. You'd never see a study like this conducted. But studies on medical applications and doses? Absolutely. Studies on average bodybuilding doses? Yes, many have been conducted.

To answer your question, yes, these studies are good information. They are peer-reviewed, published in medical journals for free access to anyone who wishes to review the material.

[Atomini]

Have you not read any of the Q&A posts...friggin thing is full og Var ONLY cycles every week!

Yeah its one of the reasons I wanted to create this thread. LOTS of people under the age of 24 asking if its okay to run an Anavar -only cycle because they read (or heard) elsewhere that Anavar is a 'mild' AAS, and so they think they can avoid the potential long-term damage to their HPTA if they use Anavar. Well, to put it simply: they are wrong, and so is whatever source they heard from that Anavar is 'mild' on the HPTA.

[blacksmoke]

You mention that anavar may be more anabolic anadrol . I'd like to here more about this.
Great post by the way.

[Atomini]

You mention that anavar may be more anabolic anadrol . I'd like to here more about this.
Great post by the way.

Well, that was a very generalized comment of mine, but it's something i'd like to post about in the future. I've realized that Anavar is possibly far better at building mass (without the bloating and water weight) than everyone seems to think. It's Primobolan that is so utterly weak that its practically useless for anyone.

[t-dogg]

LOL Im still wondering why jose c said its ok to run anavar year round...

[Atomini]

Yeeaaahhh.... I am actually going to keep my mouth shut on that. I don't want to say anything more than that it is a very stupid idea. I'm sorry, but Jose is dead wrong there. I also hear the same stuff from gym bros who say Anavar is a great compound to bridge with or to use year-round safely because it's 'mild'. No, it isn't mild on your HPTA and if you use it year round without periodic use of HCG or something, you are going to screw your endocrine system up, no doubt about that. Liver wise it's not a good idea either. Even medical prescription guidelines reccomend Anavar to be used for no longer than a 3 month period MAXIMUM.

[MickeyKnox]

Absolutely fantastic, Atomini. Thank you very much for another intelligently written article.

You can be assured I will be using this thread as a reference link.

[Rv8G30]

This might be a little off topic but if someone was to run test enanthate and anavar would you recommend a trt dose of test and high amount of anavar? Like you say about tren ? Or would test at 500mg / wk be better with anavar?

[Bertuzzi]

Great post.... I know when I ran VAR only years back it shut me down hard. Glad to have a study and some science backing it up as I only have personal experience with blood work of course to go off of.

Thanks for the post, Great info.

[Atomini]

Absolutely fantastic, Atomini. Thank you very much for another intelligently written article.

You can be assured I will be using this thread as a reference link.

Yes, I implore you and anyone else to reference this thread/information to those common posts you always see about Anavar being 'mild', especially the posts made by kids who think that using Anavar because it's 'mild' will prevent any potential HPTA damage.

This might be a little off topic but if someone was to run test enanthate and anavar would you recommend a trt dose of test and high amount of anavar? Like you say about tren? Or would test at 500mg / wk be better with anavar?

I always advocate a TRT dose with anything and everything if you're stacking stuff with Testosterone . There are several benefits to doing this, such as controlling Estrogen without the use of an AI, and allowing yourself to see the sole benefits from the primary anabolic you are using as opposed to Testosterone. I have nothing against using higher doses of Testosterone (such as 500mg weekly) stacked with other things like Anavar, but you must be aware that with the higher dose of Testosterone, you are going to have more aromatization and you will have to be prepared to take the steps necessary to deal with that.

[RoadToHuge]

I run it at 350 to 400 and 400 tren .. 100 mg var for 2 weeks at start, and 4 weeks at end of cycle. All ethanates..

[kelkel]

Great info Atomini. I know anavar has a profound effect on me. The again I run it with test and tren. I really love those three together. Now if I could figure out how to get my appetite back I would be set!

GHRP-6 will do it...

[Atomini]

I haven't had appetite issues on Anavar . I'm runnign 100mg daily of it with 200mg Trenbolone and 100mg testosterone weekly.

[Rv8G30]

Yes, I implore you and anyone else to reference this thread/information to those common posts you always see about Anavar being 'mild', especially the posts made by kids who think that using Anavar because it's 'mild' will prevent any potential HPTA damage.



I always advocate a TRT dose with anything and everything if you're stacking stuff with Testosterone. There are several benefits to doing this, such as controlling Estrogen without the use of an AI, and allowing yourself to see the sole benefits from the primary anabolic you are using as opposed to Testosterone. I have nothing against using higher doses of Testosterone (such as 500mg weekly) stacked with other things like Anavar, but you must be aware that with the higher dose of Testosterone, you are going to have more aromatization and you will have to be prepared to take the steps necessary to deal with that.

Thanks for the response. What about from a lean gain standpoint? Say all conditions are equal like diet and training. What option you think would provide better gains?

[Atomini]

I would stick to TRT dose of Testosterone with a higher dose of Anavar if those are the gains you want. That's what i'm currently doing, although I am cutting. It is still going very well regardless. Ever since I have run Testosterone at TRT doses and allowed the other compounds I am using with it to be the primary anabolic workhorse, I have seen amazing changes and benefits that far surpass the years I would run Testosterone at 400 - 500mg weekly with other stuff. Everyone has their preference though, but mine is to run Testosterone at a TRT dose if I am using another compound with it.

[RoadToHuge]

Tren seems to blunt my appetite.. not the var.

[RoadToHuge]

Thanks, will do this for next cycle.. Getting to my 215 @10% goal is going to take some eating..

[Bonaparte]

Well, that was a very generalized comment of mine, but it's something i'd like to post about in the future. I've realized that Anavar is possibly far better at building mass (without the bloating and water weight) than everyone seems to think. It's Primobolan that is so utterly weak that its practically useless for anyone.

I have to disagree. Primo at a solid dose is amazing. Not Trenbolone amazing, but the gains to side effects ratio cannot be beat.

[testluva]

Great post Dr Atomini. We need bro's like you helping us out with posting these research studies. What about Deca ? Do you have any info in this compound?

[Atomini]

I have to disagree. Primo at a solid dose is amazing. Not Trenbolone amazing, but the gains to side effects ratio cannot be beat.

Yes, you are correct - I seem to be making too many generalized statements lately about Primo. I should clarify myself and state that the cost:benefit ratio is quite high for Primo compared to Anavar or many other AAS. Primobolan is very weak, and so in order to grasp its benefits, it must be run at a very high dose. I have never used Primobolan myself but everything I have seen and heard shows that when used at the appropriate effective dose, it is a great compound. The problem is, of course, cost:benefit.

Great post Dr Atomini. We need bro's like you helping us out with posting these research studies. What about Deca? Do you have any info in this compound?

I haven't looked into Nandrolone very much yet, but I will be very shortly. I do know that there is already a solid base of evidence out there that shows that Nandrolone is also not as 'mild' as once thought, and is very suppressive on the HPTA. It's almost common knowledge by now.

[warmouth]

Holy Crap Atomini! Youve done it again. And this is the perfect thread for everyone who thinks anavar is "mild". I ran it and loved it, but it was anything but mild. I suffered horrible insomnia, night sweats, cotton mouth, cramps, spasms, but the worse of it was the sleeplessness. I try to tell everyone that it isnt as mild as it is made out to be. In my case, it was like tren sides(from what Ive heard) and was brutal until about a week after I finished up. Everything got back to normal(sleep wise). But my lipids and liver enzymes took a big hit. Great post, and I am still looking for that one the I KNOW you have been putting together for masteron !

On a side question, when you delve into nandrolone , what is going to be your dosing protocol? TRT+high nandrolone, 50/50, high test/low nandrolone? Just curious to what you are going to do because I have mine on standby and am pondering what I am going to do about mine. I am thinking a Test:NanDec ratio of about 600:400, but still unsure. Dont want the nasty sides of the NanDec, thats why I was thinking about running the test a bit higher. Sorry to venture off of this great topic. Great work!

[MuscleInk]

Great post Atomini. Good to see some evidence backing up many of the comments posted about Anavar suppression. I'll be referring to this post often and looking up the pub you referenced!

Well done, as usual.

[Rv8G30]

Holy Crap Atomini! Youve done it again. And this is the perfect thread for everyone who thinks anavar is "mild". I ran it and loved it, but it was anything but mild. I suffered horrible insomnia, night sweats, cotton mouth, cramps, spasms, but the worse of it was the sleeplessness. I try to tell everyone that it isnt as mild as it is made out to be. In my case, it was like tren sides(from what Ive heard) and was brutal until about a week after I finished up. Everything got back to normal(sleep wise). But my lipids and liver enzymes took a big hit. Great post, and I am still looking for that one the I KNOW you have been putting together for masteron !

On a side question, when you delve into nandrolone, what is going to be your dosing protocol? TRT+high nandrolone, 50/50, high test/low nandrolone? Just curious to what you are going to do because I have mine on standby and am pondering what I am going to do about mine. I am thinking a Test:NanDec ratio of about 600:400, but still unsure. Dont want the nasty sides of the NanDec, thats why I was thinking about running the test a bit higher. Sorry to venture off of this great topic. Great work!

Whoa I didnt realize the sides were this bad especially the sleeplessness part. Makes me reconsider doing a trt dose of test and high anavar dose. Maybe i should just do normal 500mg test and var at the end. If sides get too bad then i can drop var and finish as test only cycle.