I was wondering if on cycle, what would happen if you took letrozole and clomid together on cycle. More specifically if you were taking enough letrozole to severely reduce estrogen would you be able to accurately control your estrogen levels by adding in the clomid, for libido/mood? A weird question I know and I'm not going to do it, just thought the concept was interesting. I suppose it depends what estrogen receptors in the brain clomid actually activates.