"suicide AIs"

[PJS19]

If I used a product marketed as a suicide inhibitor and crashed my e2, does that mean it wont bounce back up ever? How long does it take to unbind or create new enzymes. 2.5 months after using one and it hasnt restored. I used one without using any steroids before so there wasnt excess testosterone to aromtase in the first place. Is the word permanent true or will my body eventually restore itself, just needs more time?

[MuscleInk]

If I used a product marketed as a suicide inhibitor and crashed my e2, does that mean it wont bounce back up ever? How long does it take to unbind or create new enzymes. 2.5 months after using one and it hasnt restored. I used one without using any steroids before so there wasnt excess testosterone to aromtase in the first place. Is the word permanent true or will my body eventually restore itself, just needs more time?

Suicide inhibitors are generally a class of catalytic substrates that form covalent bonds to irreversibly inactivate an enzyme (such as aromatase). After the catalytic processes occur, the chemically reactive intermediate covalently binds to the enzyme and inhibits it. Suicide inhibitors are bound to the active site and prevent further reactions that could have occurred with the active site and its substrates.

Exemestane (aromasin) is an irreversible, aromatase inactivator. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation ("suicide inhibition"). By being structurally similar to aromatase, Exemestane permanently binds to the aromatase, preventing the enzyme from converting androgen into estrogen.

Your body will eventually manufacture more aromatase enzymes and your E2 will recover quickly when the AI is discontinued.

[PJS19]

Suicide inhibitors are generally a class of catalytic substrates that form covalent bonds to irreversibly inactivate an enzyme (such as aromatase). After the catalytic processes occur, the chemically reactive intermediate covalently binds to the enzyme and inhibits it. Suicide inhibitors are bound to the active site and prevent further reactions that could have occurred with the active site and its substrates.

Exemestane (aromasin) is an irreversible, aromatase inactivator. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation ("suicide inhibition"). By being structurally similar to aromatase, Exemestane permanently binds to the aromatase, preventing the enzyme from converting androgen into estrogen.

Your body will eventually manufacture more aromatase enzymes and your E2 will recover quickly when the AI is discontinued.

Thanks for that information. Do you think its strange that its been 2.5 months since discontinuation and I dont feel better? Or is that normal and its a timely process?

[brazey]

Can you get bloodwork done and post results? That's the only way to know for sure what's going on.

[MuscleInk]

Can you get bloodwork done and post results? That's the only way to know for sure what's going on.

^^^This. There could be numerous factors. A full blood panel would be key to properly diagnosing the causal factors.

[AD]

Thanks for that information. Do you think its strange that its been 2.5 months since discontinuation and I dont feel better? Or is that normal and its a timely process?

its really hard to "feel" your estro level. symptoms are too general and non-specific.

and i think its really unusual(almost impossible) for your aromatase activity to be decreased after stopping aromasin 2 months ago.

[C3RB3RUS]

^^^This. There could be numerous factors. A full blood panel would be key to properly diagnosing the causal factors.

right. normally people use Exemestane (aromasin ) while on cycle and during pct. sounds like you've got a less than regular situation, so the regular answers that usually solve everyone's problems aren't going to solve yours. why did you use it by itself [did you really use it by itself?] and for what reason did you buy it; not to purposely crash your E2, right? what were you trying to feel better from? i know it's easy to ask questions because most of the answers are so fast, but doing your own research will make you smarter. [i need to read more myself] "messing around with chemicals" can become so run of the mill, but never loose your respect for them. I was thinking that to myself earlier today. you got medical? docs are good for times when you are feeling like shit and can't fix it yourself. BTW, see "The Incredible Burt Wonderstone." it's pretty ok. James Gandolfini is kind of in it.

[PJS19]

I have gotten 3 blood tests done in past 3 months. 2 endos and now a specialist. At first I thought low T was the main issue , which it might be, T was in 300s for first 2 tests (april/may). The product i took also had epistane so that prpbably shut me down a little. But in June my T was in 600s, although free T was still low at 85. The first 2 tests didnt do estrodial but the specialist did and it was at 6. (in june, i stopped product in april). Everything else was fine. He said the e2 test isnt reliable and he thinks low T is still the issue because LH is at 2, and has been for all 3 tests. He prescribed me clomid

I took the product because I have in the past and got real lean on it. Also I had a sensitive nipple before I took it, and it cleared that up in 3 days. I stopped the product after 10 days when I became emotionless/apathetic, and still am. Been spending past 3 months trying to find a solution

[crazy mike]

OP I'm not sure that "emotionless/apathetic" are so much the targets of low E2. And as was said you need more tests. Also the testing of you E2 was not done regularly with you oher tests. The doctors don't like o teat what you want. Get more tests with Estradiol and have someone evaluate all the results also what about you RBC. Anyway let me ask are you depressed. Just a Question OP and I didn't get how your appetite is , I didn't see that can you tell us more as to your symptoms ?. ...crazy mike

[AD]

How long have you been on clomid? What dose? It should increase your test and estro as well. So either way, you should get better.

[PJS19]

Ive been on clomid for 8 days, 50mg per day. Havent felt a change. And crazy mike, I dont think im necessarily depressed. But I think thats because I have nothing to be depressed about. I get depressed and hopeless sometimes because Im frusterated with the inability to have emotions. But its not a sadness per say. Low libido, no motivation, dont care about anything, light headed when working out, irritibility are symptoms. I feel lifeless. My appetitie is fine though.

I should mention end of april i took nolvadex for 5 days to see if it would help. On the 3rd day I felt like myself again, like a switch turned on. But it went away and my doctor urged me to stop taking drugs so I stopped at day 5

[PJS19]

was going to start a new thread, but I figured I'd update this one. Does anyone have experience with suicide inhibitors where there e2 doesnt rebound after stopping. My e2 is still in the single digits (7)..6 months after stopping the product. 3 months after e2 was at 6, even with a total T of 640.

It seems like its not bouncing back, and I think these levels are way too low.

[jimmyinkedup]

What ai did you use?

[PJS19]

the ingredient is Androst 3,5-dien-7, 17-dione.

In a product called "arime stage 5 pct" by EPG. Also contains low dose epistane. Only took it for 10 days back in april!

[jimmyinkedup]

seriously doubt the correlation.....

[PJS19]

What do you mean Jimmy?

I should add, prior to taking it I had a sensitive nipple on one side. Early signs of gyno I think. But after a few days, that sensitivity dissapeared.

[jimmyinkedup]

I cant imagine 10 days of an otc supp can do that. thats all. I could be wrong.

[PJS19]

I agree with you. Thats why Im so shocked at how much damage those 10 days have caused for me the past 6 months. Insane. Blood work doesnt lie, and the epistane in it shut me down and e2 is still low. LH/FSH still in the 1's six months later and after using clomid for a month. Crazy.