Testosterone negative feedback loop inhibitor?

**goingstronger** · 10-02-2013, 02:37 PM

Hey guys!

Look at this :

medicalhealthtests.com/pathology-test/clonidine-suppression-test-plasma.html]Clonidine Suppression Test: Reasons, Procedure and Preparation

This is a substance that suppresses negative feed back loop in the Hypothalamic–pituitary–adrenal axis. It tricks the brain into thinking there is not enough hormone so it produces more.

Is there any similar substance that would work for the Hypothalamic–pituitary–gonadal axis, so that the brain is fooled into thinking there is not enough testosterone , and it would produce more?

I am not talking about stimulators like clomid here, but something that really deactivates the transmitors telling the brain testosterone is made.

Thanks!

**qscgugcsq** · 10-02-2013, 04:45 PM

The way I understood what you are asking is like a medication to take during cycle, to never stop producing Lh/Fsh. (stopping the retro-inhibition of the exogenous testosterone ).
If it's not what you wanted to say forget what will follow XD

I think It may be possible to synthesize, however, I don't think it exist yet(if it can be done).
The body, the brain particularly, is very complex, and works in more that one way.

I do think that if something like that would exist, Austinite would have jumped on that Info and would have shared it with us XD

On a serious note, I don't see what utility that kind of drugs could have for a pharmaceutical use.
Medication who directly suppress the HPTA are prescribed for TRT(for people already having low T)

Second, IMO playing with that loop may cause more cons that pros...
The body took million of years to find the balance and know how to react.

I agree that kind of drugs could ease a cycle plan. No more PCt or HCG . Just taking that during cycle and everything is fine. I would like to believe it but I doubt that will be as simple as that.

I really would like great minds to comment on this. Austinite, MuscleInk I'm referring to you :P

**jimmyinkedup** · 10-02-2013, 04:54 PM

Originally Posted by goingstronger

Hey guys!

Look at this :

medicalhealthtests.com/pathology-test/clonidine-suppression-test-plasma.html]Clonidine Suppression Test: Reasons, Procedure and Preparation

This is a substance that suppresses negative feed back loop in the Hypothalamic–pituitary–adrenal axis. It tricks the brain into thinking there is not enough hormone so it produces more.

Is there any similar substance that would work for the Hypothalamic–pituitary–gonadal axis, so that the brain is fooled into thinking there is not enough testosterone , and it would produce more?

I am not talking about stimulators like clomid here, but something that really deactivates the transmitors telling the brain testosterone is made.

Thanks!

that what serms like clomid do though via the very same negative feedback mechanism so i dont understand why you are dismissing them.

**Xaxist** · 10-02-2013, 08:53 PM

Are you asking specifically about Clonidine aka Catapres? Or is this a general question? (sorry, a little confused here)

**goingstronger** · 10-03-2013, 02:04 PM

Clonidine was just an exemple I took to picture the mechanism of action it has on the Hypothalamic–pituitary– adrenal axis, and investigate wether one would be able to replicate it for the Hypothalamic–pituitary–gonadal axis, that is suppressing the negative feedbalck loop mechanism.

You understood well! But it is not for cycles neither to recover from them. I've never taken any form of steroid . It would be as a standalone. How I see things is if there is no signal (or if the brain is blocked from receiving one) telling testosterone is made, it will keep producing it so that you'll have supraphysiological levels circulating!

I don't see what bad it can do if I am taking an AI along, and if you dose it correctly so that you don't die from testosterone surplus.

I think it's kind of what ATD used to do, but the downside of it is that it desencitized the brain to DHT effects, which is the last thing I want...

Cheers from France!

**jimmyinkedup** · 10-03-2013, 02:27 PM

I think you will find the effect to be limited however. Say a 20-50% increase in testosterone , remember there has to be limits on the amount of GnRh the body can produce and subsequently LH and FSH. Im not sure it would ultimately be benficial (dependant upon goal). The simple administration of an Ai like arimidex increases test lelvels something like 58% however in a study performed this increase,as substantial as it may sound,did not equate to any clinically significant change in body composition so Im not sure what would ultimately be accomplished by using a substance like you are referring too.

**kelkel** · 10-03-2013, 03:43 PM

Originally Posted by goingstronger

Clonidine was just an exemple I took to picture the mechanism of action it has on the Hypothalamic–pituitary– adrenal axis, and investigate wether one would be able to replicate it for the Hypothalamic–pituitary–gonadal axis, that is suppressing the negative feedbalck loop mechanism.

You understood well! But it is not for cycles neither to recover from them. I've never taken any form of steroid . It would be as a standalone. How I see things is if there is no signal (or if the brain is blocked from receiving one) telling testosterone is made, it will keep producing it so that you'll have supraphysiological levels circulating!

I don't see what bad it can do if I am taking an AI along, and if you dose it correctly so that you don't die from testosterone surplus.

I think it's kind of what ATD used to do, but the downside of it is that it desencitized the brain to DHT effects, which is the last thing I want...

Cheers from France!

Explain that one.

**jimmyinkedup** · 10-03-2013, 04:17 PM

Originally Posted by kelkel

Explain that one.

Yeah I missed that gem ... How I do not know....

**Lemonada8** · 10-04-2013, 08:50 AM

AI's and SERMs are what you are asking.

But the levels of test wont go that high to produce a noticable effect as a standalone test booster

**goingstronger** · 10-04-2013, 03:07 PM

Originally Posted by kelkel

Explain that one.

Blood getting too thick I guess, hematocrits too high.

I found that 7,8-Benzoflavone was actually what I am looking for. It works by binding to GABAergic receptors and is able to offset hypothalamic suppression of GnRH from steroid hormones.

I don't know if it is a scam from Sustain Alpha, or if actual study backs those statements.

**Lemonada8** · 10-04-2013, 08:26 PM

Sounds like BS. Esp if they claim noticeable suoraphysiologic levels (not raising low T, but raising normal T)

And I don't understand how clonidine acts like you said... It's a alpha 2 agonist... Aka centrally acting alpha agonist...
Dunno what u mean by suppress the adrenals...