receptor question.

[4linked]

So iv been doing some reasearch on receptors and a guy planning on a different forum running a big cycle for his second cycle. Like test tren mast decca anadrol dbol tons of gear.

They were saying his receptors wouldnt respond to doing a smaller cycle later that he would have to run that much gear again in order to grow.

Im just curious on peoples thoughts on this. Example- i feel like if i was 150 lbs and did a huge cycle and got to 200 lbs then stoped working out and droped back to 150 does that mean 500mg test cycle wouldnt make me grow from 150 lbs anymore? I believe it would make u grow.

It was an older thread and i cant find much info on androgen receptors. Im just curious about this

[jimmyinkedup]

Androgen receptors do not downregulate. In fact your body is constantly producing androgen reseptors. In the presence of excess androgens the life expectancy of the androgen receptor almost doubles and also does the rate of production of new androgen receptors. The fact is the androgen receptors you are using are constantly changing. You can respond well to smaller cycles down the road.

[4linked]

Thank you for your reply jimmy

[jimmyinkedup]

Thank you for your reply jimmy

NP - study and refs follow shortly.

[4linked]

Thank you i would like to read them

[jimmyinkedup]

Androgen Receptor Upregulation

Karl Hofman

Although reported half-lives and production rates of the androgen receptor (AR) vary somewhat according to the cells examined, the values reported in the abstract below are fairly typical. In the absence of androgen the AR has a half-life of about 3 hours. This means that after 3 hours 50% of the androgen receptors initially present have been degraded and replaced with new androgen receptors. In the presence of ligand, the half life of the AR is extended to over 6 hours and the production rate of new AR was almost doubled.
Androgen receptors do not fill up. They are constantly being produced, enzymatically degraded, and replaced with new receptors.

J Biol Chem. 1985 Jan 10;260(1):455-61.
Mechanism of androgen-receptor augmentation. Analysis of receptor synthesis and degradation by the density-shift technique.
Syms AJ, Norris JS, Panko WB, Smith RG.
The ductus deferens smooth muscle tumor cell line (DDT1MF-2) contains receptors for, and is stimulated by, androgens. Cells cultured in the absence of androgens maintain a basal level of androgen receptors. Following incubation with various concentrations of the synthetic androgen methyltrienolone (R1881) for 1-6 h, the concentration of these receptors increased from 6.0 to 12.2 fmol/micrograms of DNA, while the equilibrium dissociation constant (Kd) of 0.5 nM for this steroid remained unchanged. The steroid-induced increase in androgen receptor levels was specific for androgens and dependent upon protein synthesis. The mechanism of receptor augmentation was examined by utilization of isotopically dense amino acids to determine rates of receptor appearance and degradation in the presence or absence of [3H]R1881. In the absence of androgens, the half-life of the androgen receptor was 3.1 h, with a rate constant (kD) of 0.22/h. In the presence of 1 nM [3H]R1881, however, the half-life was 6.6 h, with kD = 0.11/h. The rate constant for receptor synthesis (ks) in the absence or presence of [3H]R1881 was calculated to be 1.35 and 2.23 fmol/micrograms of DNA/h, respectively. Thus, androgen-induced androgen-receptor augmentation is explained by an increase both in receptor half-life and in rates of receptor synthesis.


Thanks Nandi (RIP)