Edema in my legs while on winnie

[1wheelr1]

Running prop 300 ew Winnie 50 ed been on 3 weeks now and all of a sudden I've got this swelling in my legs mostly my calves. I took a oxycodon 40mg yesterday (the kind with no acetaminophen) I've never experienced this b4...

Is this a liver issue?!?!

[1wheelr1]

Also I just cut my water back to 1.5 gallon from 2 a day. Should I stay at 2 or more?

[madmuscler]

Did you notice the swelling after you took the oxy? Opiates make you retain serious water

[1wheelr1]

Did you notice the swelling after you took the oxy? Opiates make you retain serious water

Yes only after the opiates.

[RangerDanger830]

Pshhh, I wish I'd get water retention only in my calves. Sure beats a billion calf raises only to never be satisfied with them

[1wheelr1]

Pshhh, I wish I'd get water retention only in my calves. Sure beats a billion calf raises only to never be satisfied with them

Well it's my whole body but more noticeable in my legs.....

[RangerDanger830]

Well it's my whole body but more noticeable in my legs.....

I know what you mean, I was just messing around in a poor attempt at keeping these forums somewhat entertaining while still educational. Liver problems do cause water retention but usually only when your liver is pretty bad off. There are a few possible culprits, your diet being another one. The only way to rule out your liver unfortunately is bloodwork.

[1wheelr1]

At this point I believe it was the oxy. My diet is on point I have a show in 2 weeks.

[RangerDanger830]

Why did you take that?

[Bert]

Is it painful?

[1wheelr1]

Is it painful?

No, not at all

[1wheelr1]

Why do opiates cause water retention??

[madmuscler]

Copy and pasted

Opiates can cause peripheral edema and the effect is dose-related. The exact mechanism of opiate-induced edema is unclear but the following plausible mechanisms may be involved: a) by causing histamine release, morphine results in venodilation and this effect is dose-related (Grossman, 1996, Gardener-Nix 2002); b) opioids cause vasopressin release from posterior pituitary and this results in antidiuresis and retention of fluids leading to edema; and c) it's been shown in animals that by activating central opioid receptors, opioids enhance renal tubular sodium reabsorption -- this can cause edema and may block the aquaporins leading to retention of water (Huidoboro, 1981).

[1wheelr1]

Copy and pasted Opiates can cause peripheral edema and the effect is dose-related. The exact mechanism of opiate-induced edema is unclear but the following plausible mechanisms may be involved: a) by causing histamine release, morphine results in venodilation and this effect is dose-related (Grossman, 1996, Gardener-Nix 2002); b) opioids cause vasopressin release from posterior pituitary and this results in antidiuresis and retention of fluids leading to edema; and c) it's been shown in animals that by activating central opioid receptors, opioids enhance renal tubular sodium reabsorption -- this can cause edema and may block the aquaporins leading to retention of water (Huidoboro, 1981).

Best possible answer I could've imagined! Thank you very very much!!!

[madmuscler]

No problem

[1wheelr1]

Wish all my threads were answered so precisely!