nolva and clomid

[BigGuns89]

hi guys

just doing some reading on nolvadex and clomid effect on the eyes, i knew clomid has been reported to cause blurred vision and can make vision decline - dont know whether thats temp or perm tho. im reading that nolvadex has a negative effect on the eyes also such as cataracts and other eye problems.

ive recently had lasik eye surgery and so im even more concerned about keeping my vision 20/20, im not sure if i want to do nolva/clomid for pct now and im seeing nolvadex causes liver cancer etc. im probably being a bit para and ive used before with no notable issues

[jimmyinkedup]

A basic anti oxidant should do the trick as far as prevention:

Tamoxifen , ocular toxicity, & oxidative stress

The article linked to below proposes that the ocular damage caused by tamoxifen is due to oxidative stress. The authors suggest that the use of antioxidants may help prevent such damage.

Exp Biol Med (Maywood). 2004 Jul;229(7):607-15.

Oxidative stress plays an important role in the pathogenesis of drug-induced retinopathy.

Toler SM.

Clinical Safety and Risk Management, Pfizer Inc., Pfizer Global Research and Development, 50 Pequot Avenue, New London, CT 06320. [email protected]

Several pharmaceutical agents have been associated with rare but serious retinopathies, some resulting in blindness. Little is known of the mechanism(s) that produce these injuries. Mechanisms proposed thus far have not been embraced by the medical and scientific communities. However, preclinical and clinical data indicate that oxidative stress may contribute substantially to iatrogenic retinal disease. Retinal oxidative stress may be precipitated by the interaction of putative retinal toxins with the ocular redox system. The retina, replete with cytochromes P450 and myeloperoxidase, may serve to activate xenobiotics to oxidants, resulting in ocular injury. These activated agents may directly form retinal adducts or may diminish ocular reduced glutathione concentrations. Data are reviewed that suggest that indomethacin, tamoxifen, thioridazine, and chloroquine all produce retinopathies via a common mechanism-they produce ocular oxidative stress

Full article can be accessed here:

Oxidative Stress Plays an Important Role in the Pathogenesis of Drug-Induced Retinopathy