Vitamin E to significantly lower prolactin?

[AR's King Silabolin]

Check this out..

Twenty-four uremic patients on hemodialysis who had never been treated with vitamin E or related drugs and 12 control patients with normal renal function were studied. Hemodialysis patients were randomly divided into two groups; 12 were treated with oral vitamin E (300 mg/day) for eight weeks and 12 uremic patients and 12 controls were given placebo. Serum vitamin E, prolactin, FSH, LH, and free testosterone levels were measured in all patients before and after treatment. After the vitamin E treatment serum prolactin levels were significantly decreased (50.8 vs 15.4 ng/ml, p < 0.01). Vitamin E levels were significantly increased (1.11 vs 1.22 mg/dl, p < 0.05). Serum FSH, LH and free testosterone were not affected. In the other two groups there were no significant changes. These results show that vitamin E treatment lowers prolactin levels in uremic hemodialysis patients. This might be due to inhibition of central prolactin secretion. Vitamin E inhibits pituitary gland hypertrophy in vitamin E-deficient rats.

Thats some real stuff. You think it also relates to non uremic humans?

I ****ed up my e2 and prolactin again from just 150 mg test p a a week and i started aromasin , but hey...can this herbguy at my store really fix prolactin?

Thougths?

[mark woods]

Interesting alri as I tought the same about b6 but It don't seem to help me much on tren so I have to use caber instead but I would try it I suppose...

[Bonaparte]

Check this out..

Twenty-four uremic patients on hemodialysis who had never been treated with vitamin E or related drugs and 12 control patients with normal renal function were studied. Hemodialysis patients were randomly divided into two groups; 12 were treated with oral vitamin E (300 mg/day) for eight weeks and 12 uremic patients and 12 controls were given placebo. Serum vitamin E, prolactin, FSH, LH, and free testosterone levels were measured in all patients before and after treatment. After the vitamin E treatment serum prolactin levels were significantly decreased (50.8 vs 15.4 ng/ml, p < 0.01). Vitamin E levels were significantly increased (1.11 vs 1.22 mg/dl, p < 0.05). Serum FSH, LH and free testosterone were not affected. In the other two groups there were no significant changes. These results show that vitamin E treatment lowers prolactin levels in uremic hemodialysis patients.

Thats some real stuff. You think it also relates to non uremic humans?

No. They literally just dispelled that idea above. But P-5-P (a more potent form of B6) is known to be effective, so use that instead.

In bold.

[AR's King Silabolin]

ah.....its obvious. How could i not see this. Feel stupid....but im no native englisher. Youre rigth napoleon, it doesnt work on non uremics. And i just gave 60 dollars to the herbguy...ahhhhhh

P-5-P...i will look it up...Vets are vets!!

[mark woods]

So what dose is recommended for lowering prolactin of b6 or is it trial and error I'm using 150mg a day and my nipps are giving me hassle so I switched back to .5mg caber 2xweek...I rather b6 tho as it's cheaper!!

[AR's King Silabolin]

So what dose is recommended for lowering prolactin of b6 or is it trial and error I'm using 150mg a day and my nipps are giving me hassle so I switched back to .5mg caber 2xweek...I rather b6 tho as it's cheaper!!

Vitamin B6

Vitamin B6 is a surprisingly effective prolactin inhibitor that is extremely cheap and safe:

One human study showed a single 300mg dosage of B6 exerts ‘a hypothalamic dopaminergic effect’ which causes a ‘significant decrease of plasma prolactin’(1);
Another found that 300mg of B6 taken twice a day by 10 normal women lowered prolactin levels and slightly but significantly raised growth hormone levels. The authors concluded: ‘The effect of vitamin B6 is likely to be mediated by dopaminergic receptors at hypothalamic level’(2);
Another study found B6 to significantly reduce ‘opioids-induced hyperprolactinemia’(3);
This study on men found that ‘Pyridoxine (B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exercise’(4);
And a study on male rats found that, ‘Pyridoxine hydrochloride significantly suppressed the chlorpromazine-induced prolactin rise (p less than 0.01). However, the suppression was significantly less than that produced by bromocriptine (p less than 0.01)’(5).

[Note: The last study shows B6 to be less effective than Bromocriptine as a prolactin inhibitor but, stacked with vitamin e and SAM-e, along with some of the secondary prolactin inhibitors I list at the bottom of the page, effects comparable to bromocriprine can be achieved.]

The vast majority of people receive the very low RDA for vitamin b6 (2mg) from their diets so this isn’t an issue of correcting a deficiency. It appears, instead, that extra vitamin B6, i.e. around 600mg spread throughout the day, acts in a drug like manner to lower prolactin levels.

It’s important to realize, however, that the RDA for B6 is set extremely low and many people benefit from getting considerably more than 2mg per day of this vitamin. Vitamin B6 in high doses has been shown in studies to:

– Reduce high blood pressure.
– Improve mood and combat depression
– Lower blood sugar levels in diabetics
– Act as an effective calcium channel blocker

A very high dose of B6 may act as a prolactin inhibitor in certain people by correcting a functional deficiency of this vitamin that can occur. Inflammation in the body can create a greater demand for B6 so bodybuilders and athletes may require more of this vitamin.

Pyrolurics, according to Dr. Carl Pfeiffer and Dr. Abram Hoffer, have an increased need for zinc and B6. People suffering from this illness create abnormally high levels of chemicals called kryptopyrroles, which bind to zinc and B6 in the body, creating deficiencies in both.

The standard treatment for pyroluria is high dose zinc and B6 supplementation, typically 50-150 mg and 250-1500 mg respectively (way above the RDA for both).

Side effects:

High doses of B6 taken for many months can cause nerve problems such as tingling in the fingers and numbness in the toes (peripheral neuropathy); B6 can also worsen sleep quality in some people and cause vivid dreams.

Fortunately, these problems completely resolve once B6 supplementation is stopped and, since it is water soluble, this won’t take too long.

Ways around these side effects:

One way to avoid the ‘finger tingling’ that high dose B6 can cause is to take the activated form of B6 called Pyridoxal-5-Phosphate (P5P) – the activated form of B6 does not cause these nerve issues.

In fact, the reason that high dose B6 causes nerve problems is that the body can’t always process very high B6 doses properly and this creates a deficiency of the active form of B6, P5P.

Recommended dosage:

To lower prolactin levels I would recommend you take 50 to 200mg of P5P a day, in divided doses. If you want to take regular B6, which as I’ve mentioned can sometimes cause minor side effects, take 300 to 1000 mg per day in divided doses.

Read the label before you buy B6 because the Pyridoxine Hydrochloride type of B6 (in most supplements) has been shown to be a prolactin inhibitor but Pyridoxal hydrochloride has been shown to be ineffective at lowering prolactin (6) – make sure you buy the right type!

[kelkel]

So what dose is recommended for lowering prolactin of b6 or is it trial and error I'm using 150mg a day and my nipps are giving me hassle so I switched back to .5mg caber 2xweek...I rather b6 tho as it's cheaper!!

If you're making any effort with an AI for E2 control then you should be able to drop your caber dose back to .25 x 2 per week and achieve the desired effect. Save the rest for your next cycle.

[Frontpump]

B6 has been shown to be neuro-toxic at doses above 200mg in some patients. These studies say the effects are reduced with cessation, but some damage remains permanent.

I don't have the source, but anybody can look it up. B6 is one of the only vitamins known to be toxic in high doses. Some use high doses with no sides, others are not that lucky. for me, it totally destroys my sleep. Proceed with caution.

[mark woods]

If you're making any effort with an AI for E2 control then you should be able to drop your caber dose back to .25 x 2 per week and achieve the desired effect. Save the rest for your next cycle.

I rarely use an AI,my test dose is always low,and so is my e2,my issues occur when tren is added only then do I get nipp issues and they go when tren stops so it's a prolactin issue I'm guessing,once I feel it's helping yes I will lower the dose as above,just wondering if anyone has used p5p or high dose b6 for prolactin issues with success when tren is in the mix,purely from saving money stance?

[Bonaparte]

B6 has been shown to be neuro-toxic at doses above 200mg in some patients. These studies say the effects are reduced with cessation, but some damage remains permanent.

I don't have the source, but anybody can look it up. B6 is one of the only vitamins known to be toxic in high doses. Some use high doses with no sides, others are not that lucky. for me, it totally destroys my sleep. Proceed with caution.

That was already covered in post #6.

[Ashop]

B6 has been shown to be neuro-toxic at doses above 200mg in some patients. These studies say the effects are reduced with cessation, but some damage remains permanent.

I don't have the source, but anybody can look it up. B6 is one of the only vitamins known to be toxic in high doses. Some use high doses with no sides, others are not that lucky. for me, it totally destroys my sleep. Proceed with caution.

I was about to post similar info. I also would be careful of too high of dosages with B6,,it can be toxic in large amount.

[Mr.BB]

I rarely use an AI,my test dose is always low,and so is my e2,my issues occur when tren is added only then do I get nipp issues and they go when tren stops so it's a prolactin issue I'm guessing,once I feel it's helping yes I will lower the dose as above,just wondering if anyone has used p5p or high dose b6 for prolactin issues with success when tren is in the mix,purely from saving money stance?

Why guess? Do some bloodwork to be sure.

[Frontpump]

That was already covered in post #6.

Post #6 says side disappear, which conflicts with med studies, and also encourages doses of 300mg or more.

If your only education on b6 were that post, you'd be misinformed.