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Thread: Compound efficacy in stacks.

  1. #1
    proteinshake1992 is offline Junior Member
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    Exclamation Compound efficacy in stacks.

    Hi all,

    Wondering if you have expierences or other sources that could prove or disprove the following suggestion.

    Does the magnitude in which one specific steroids expresses it's effect at one specific dose (let's say 200mg tren in a stack) change depending on the other steroids it's stacked with? Even though the anabolic ratio per ml of the other compounds stay relatively the same For example:

    200mg tren
    200mg test

    Vs

    200mg tren
    100mg deca
    100mg test

    Does tren have a different effect in these two stacks when this would be taken weekly for 16 weeks at the end of the 16 weeks?

    Thanks for replying.

  2. #2
    austinite's Avatar
    austinite is offline HRT Specialist ~ AR-Platinum Elite-Hall of Famer ~
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    No.

    Tren (or any other compound) will do what they do, regardless of what is present. Combining compounds can impact side effects. but varying degrees of results (which I assume is what you're looking for) is not due to the compound working better or worse with another. Tren will do what tren does, test will do what test does. Combining them makes for better results because you're using more AAS, but does not impact each steroid 's individual performance in your body.
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  3. #3
    proteinshake1992 is offline Junior Member
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    Hi austinite,

    The reason I asked this is because I thought that AAS at certain dosages mostly/fully occupy the AR, leaving no space for other AAS to effectively bind.
    I read somewhere that some AAS bind stronger and physically different to AR thereby influencing the ability of other AAS to do their job on the receptor.

    Thanks though

  4. #4
    AlphaMindz's Avatar
    AlphaMindz is offline Knowledgeable Member
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    That's a really good question.

    It depends on the binding affinity of the drug. If you're taking an androgen that has a very strong binding affinity for the androgen receptor like tren , then other androgenic steroids like testosterone will have lower efficacy due to limited receptors sites and limited receptor space. The test will still perform its other functions apart from its action on the ar but the tren will be doing most of the work in terms of direct action at the ar.

    That's why it's best IMO to run an androgenic stacked with an anabolic and IF you are going to take two androgens then keep the stronger one at a lower dose and the weaker one at a higher dose. IME that's the optimal way to use gear BUT everyone is different and others may have something different to report lol and that's fine as we're all different. But I do think it's NOT optimal to take a high dose of tren and test. To me, it's a waste and the sides would be unnecessary but that's just me...
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  5. #5
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    Quote Originally Posted by proteinshake1992 View Post
    Hi all,

    Wondering if you have expierences or other sources that could prove or disprove the following suggestion.

    Does the magnitude in which one specific steroids expresses it's effect at one specific dose (let's say 200mg tren in a stack) change depending on the other steroids it's stacked with? Even though the anabolic ratio per ml of the other compounds stay relatively the same For example:

    200mg tren
    200mg test

    Vs

    200mg tren
    100mg deca
    100mg test

    Does tren have a different effect in these two stacks when this would be taken weekly for 16 weeks at the end of the 16 weeks?

    Thanks for replying.
    If two guys, each one runs one of the listed cycles, I would doubt that you could really tell the difference in gains. Our bodies are analog systems and will dampen out differences. A 100mg each way with Deca/Test isn't going to cause dramatic change in the body.

  6. #6
    proteinshake1992 is offline Junior Member
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    Both thanks for replying.

    @AlphaMindz
    I understand your line of thought. Are you aware of any source that rates the affinity for the different compounds?

  7. #7
    AlphaMindz's Avatar
    AlphaMindz is offline Knowledgeable Member
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    Quote Originally Posted by proteinshake1992 View Post
    Both thanks for replying.

    @AlphaMindz
    I understand your line of thought. Are you aware of any source that rates the affinity for the different compounds?
    Anytime man.

    All I've seen are anabolic to androgenic rating charts. I honestly don't know how accurate those charts are, and of course, they vary so some may be more accurate then others. I wouldn't overly concern yourself with trying to figure out an exact number that quantifies the specific androgenic nature of a drug. My advice is to keep it simple. If you're gonna run a strong androgen on top of test then just use a little bit of it. The short ester androgens produce great effects at even just 50mg eod (mast, winny, tren ) they're all great at 50mg eod.

  8. #8
    Kay kay is offline Associate Member
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    This is actually correct.

  9. #9
    Kay kay is offline Associate Member
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    For example, running a huge test dose can lead to greater aromitization and less muscle building benefit from said test due to other steroids binding affinity to the ar.

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