How you should actually take oxandrolone
I'd like to greet you with some (I hope useful) thoughts on oxandrolone administration. I've almost graduated from pharmacy, so possibly I'd have some free time and just wanted to join this awesome community, discuss things.
For the highest BV Anavar should be taken on empty stomach with a glass of slightly acidic water (apple vinegar). No milk, no coffee, no tea. Forget about your oatmeal with fruits, nuts and milk and Anavar together. You should also avoid any diuretics during it’s in the system (excess caffeine) because oxandrolone is mainly metabolised and excreted (unchanged as well) by the kidneys (quite unique in the AAS world). To limit its first pass effect, take supplements/drugs that increase hepatocytes integrity (sylimarol comes to mind). Pay attention that it raises your free cortisol despite it has general anti-GCs, weak anti-GR properties - being in a harmony with the circadian rhythm, the biggest dose should be taken in the morning (a second, smaller dose in the soon afternoon). Taking it directly before a workout is quite a nonsense.
The reasons why:
As of most AAS, oxandrolone is a weak acid and we want to limit its possible ionization in the anterior intestine (its BV is actually very high, but just to be sure).
Any meal ingredients can interact physically and/or chemically with the drug limiting its absorption (the worse are plant mucus, phytochemicals, some of fiber fractions).
Excess caffeine can increase its excretion rate a ton! I don’t even want to mention prescribed diuretics here.
You can actually slow down hepatocytes to metabolise drugs so why not to do that in this case.
All of AAS available have a general anti-GCs effect, but with different mechanisms - oxandrolone is quite unique in this regard.
Nuclear mechanism of action need time to deliver their final products, taking AAS just before a workout isn’t like taking amphetamine.
Do you feel any GI tract discomfort when taking it on empty stomach?
Drink a minimum 250-300 mL of water when administering the drug.
Optionally eat a highly-processed carb+protein, low caloric meal (like white rice with whey made on water).