Results 1 to 21 of 21
Like Tree10Likes
  • 7 Post By kelkel
  • 1 Post By redz
  • 1 Post By < <Samson> >
  • 1 Post By Gallowmere

Thread: Anavar - "little to no hepatotoxicity"

  1. #1
    ChemyoDude is offline Junior Member
    Join Date
    Jan 2020
    Posts
    108

    Anavar - "little to no hepatotoxicity"

    Taken from wikipedia - which sources https://link.springer.com/article/10...00464070-00004

    Uniquely among 17α-alkylated AAS, oxandrolone shows little to no hepatotoxicity, even at high doses.[23] No cases of severe hepatotoxicity have been singularly attributed to oxandrolone.[23] However, elevated liver enzymes have been observed in some people, particularly with high doses and/or prolonged treatment, although they return to normal ranges following discontinuation.



    Interesting...

  2. #2
    GearHeaded is offline BANNED
    Join Date
    Nov 2017
    Location
    Bragging to someone
    Posts
    8,566
    I've been touting this on here for awhile. Var at low dosages is even used to help treat alcoholic liver disease .. clearly docs are not going to prescribe something extremely hepa toxic to treat liver disease.

    of course like anything in life, too much of something can always be bad . 100mg of Var per day is going to stress the liver (just like eating 3 large mcdonalds fries per day would stress the liver).


    liver issues in bodybuilding isn't generally a problem. oral AAS is not as bad as everyone makes it out to be. its exaggerated so supplement companies can make money selling you liver protection pills

  3. #3
    ChemyoDude is offline Junior Member
    Join Date
    Jan 2020
    Posts
    108
    Quote Originally Posted by GearHeaded View Post
    I've been touting this on here for awhile. Var at low dosages is even used to help treat alcoholic liver disease .. clearly docs are not going to prescribe something extremely hepa toxic to treat liver disease.

    of course like anything in life, too much of something can always be bad . 100mg of Var per day is going to stress the liver (just like eating 3 large mcdonalds fries per day would stress the liver).


    liver issues in bodybuilding isn't generally a problem. oral AAS is not as bad as everyone makes it out to be. its exaggerated so supplement companies can make money selling you liver protection pills
    What do you consider a low yet still effective dose for what we use these things for... i.e. body building

  4. #4
    GearHeaded is offline BANNED
    Join Date
    Nov 2017
    Location
    Bragging to someone
    Posts
    8,566
    Quote Originally Posted by ChemyoDude View Post
    What do you consider a low yet still effective dose for what we use these things for... i.e. body building
    Luke Sandoe used only 20mg of Var for his Olympia prep.. it really depends on what your using it for and what your stacking it with.

    I'm starting a con prep cycle here this week. my dosage of Var starting out will only be 20mg as well. though I'd generally run 40mg, but this time around I'm stacking it/rotating it with Winny and Anadrol . as a stand alone though, I think 40mg is plenty effective.
    as an addition to TRT , 10-30mg is also fine

  5. #5
    Gallowmere's Avatar
    Gallowmere is offline Knowledgeable Member
    Join Date
    Aug 2017
    Posts
    2,378
    Anadrol is another one of these.
    They gave the shit to elderly men for 12 weeks, and jacked up liver bloods were only seen in the guys given 100mg/day the whole time. The ones given 50 saw almost nothing.
    In another RCT, 50/day was given to 30 people for a period reaching out to a year for many, and they only saw about a 20% increase in problematic markers in 17% of the patients. One of them did develop a liver tumor though, but it could have been completely unrelated.
    Considering that cycle doses of Anadrol rarely exceed these levels or run for anywhere near that long, I wouldn’t be even remotely worried about it.

  6. #6
    kelkel's Avatar
    kelkel is offline HRT Specialist ~ AR-Platinum Elite-Hall of Famer ~ No Source Checks
    Join Date
    Sep 2010
    Location
    East Coast Dungeon
    Posts
    29,657
    Quote Originally Posted by GearHeaded View Post
    I've been touting this on here for awhile. Var at low dosages is even used to help treat alcoholic liver disease .. clearly docs are not going to prescribe something extremely hepa toxic to treat liver disease.

    of course like anything in life, too much of something can always be bad . 100mg of Var per day is going to stress the liver (just like eating 3 large mcdonalds fries per day would stress the liver).


    liver issues in bodybuilding isn't generally a problem. oral AAS is not as bad as everyone makes it out to be. its exaggerated so supplement companies can make money selling you liver protection pills

    Var goes well with anything. I used 20 mgs per day to help heal from a shoulder tear. It was scripted from my doc for 6 months. No, I didn't use it the whole time but it really wouldn't have hurt. I actually got a text from my pharmacy this morning advising they had to order more so filling it will be slightly delayed. This means my doc re-upped the script after it ran out. Probably 6 more months of scripted var! Love that guy.

    Oh, and Mcdonalds fries comment was painful.
    -*- NO SOURCE CHECKS -*-

  7. #7
    redz's Avatar
    redz is online now Knowledgeable Member
    Join Date
    Nov 2007
    Location
    GTA
    Posts
    14,048
    McDonald’s fries are bad? I guess it can’t be my primary carb source anymore.
    bobspix likes this.

  8. #8
    < <Samson> >'s Avatar
    < <Samson> > is offline Neurologically Intact
    Join Date
    Feb 2012
    Location
    AZ Side
    Posts
    12,011
    Blog Entries
    2
    I’ve read this also - low doses therapeutic doses

    I dunno, but var and proV are my go 2’s for now


    imo this is quite less damaging than low dosed never ending tren

  9. #9
    ChemyoDude is offline Junior Member
    Join Date
    Jan 2020
    Posts
    108
    How long would you feel comfortable running var say at 20mgs per day?

  10. #10
    < <Samson> >'s Avatar
    < <Samson> > is offline Neurologically Intact
    Join Date
    Feb 2012
    Location
    AZ Side
    Posts
    12,011
    Blog Entries
    2
    Quote Originally Posted by ChemyoDude View Post
    How long would you feel comfortable running var say at 20mgs per day?
    I been on my combo almost 2 months

  11. #11
    ChemyoDude is offline Junior Member
    Join Date
    Jan 2020
    Posts
    108
    Quote Originally Posted by < <Samson> > View Post
    I been on my combo almost 2 months
    whats your combo? How long you gonna stay on for? Running bloods?

  12. #12
    < <Samson> >'s Avatar
    < <Samson> > is offline Neurologically Intact
    Join Date
    Feb 2012
    Location
    AZ Side
    Posts
    12,011
    Blog Entries
    2
    Quote Originally Posted by ChemyoDude View Post
    whats your combo? How long you gonna stay on for? Running bloods?

    300mg a week of some cyp + 25mg a day of var + 25mg a day of proviron &some HCG

    ^ that’s just copied from my other post

    I been on this for almost 2 months, got my BW about a month in & everything checked out well aside from my lipids being a bit up
    i_SLAM_cougars likes this.

  13. #13
    PHunter is offline New Member
    Join Date
    Jan 2020
    Location
    South Australia.
    Posts
    47
    Quote Originally Posted by Gallowmere View Post
    Anadrol is another one of these.
    They gave the shit to elderly men for 12 weeks, and jacked up liver bloods were only seen in the guys given 100mg/day the whole time. The ones given 50 saw almost nothing.
    In another RCT, 50/day was given to 30 people for a period reaching out to a year for many, and they only saw about a 20% increase in problematic markers in 17% of the patients. One of them did develop a liver tumor though, but it could have been completely unrelated.
    Considering that cycle doses of Anadrol rarely exceed these levels or run for anywhere near that long, I wouldn’t be even remotely worried about it.
    So, the things ive read about Anadrol causing liver tumours is taken from this one case? Im keen to combine lower doses of Dbol with Anadrol to kickstart my next cycle but the stories of how toxic it is and how Anadro is known to cause tumours did worry me a little.

  14. #14
    < <Samson> >'s Avatar
    < <Samson> > is offline Neurologically Intact
    Join Date
    Feb 2012
    Location
    AZ Side
    Posts
    12,011
    Blog Entries
    2
    I can only comment on what I got from it - horrid heart burn, that & sDrol

  15. #15
    magic32's Avatar
    magic32 is offline AR-Elite Hall of Famer
    Join Date
    Aug 2005
    Location
    Omnipresent
    Posts
    6,319
    Ahhhh...technically speaking, ALL low dose aas have on-book medicinal/therapeutic properties. If you'll recall that is their primary purpose.

    We use them off-book for the secondary, or maybe even tertiary, purpose of aesthetic and performance enhancement.

    I agree with the Var comments above, dosage should be contingent upon your goals, other compounds, and of course wallet.

    Again, Var (and most DHTs) can be run for looong periods (and are prescribed on-book that way), largely because they are extremely mild as evidenced by their low androgenic numbers.

    Generally at 20-80 mg, Var is optimally effective when administered twice daily (same for nearly all DHTs) due to the VERY short half-life. Tbol is 50-100 mg.
    Master Pai Mei of the White Lotus Clan



    My motto: SAFETY & RESPECT (for drugs and others).

    I AM NOT A SOURCE, I DO NOT GIVE OUT SOURCES, OR PROVIDE SOURCE CHECKS.
    I DO NOT SUPPORT ANY UGL's OR ANY ORGANIZATION DEALING WITH THE DISTRIBUTION OF ILLEGAL NARCOTICS/SUBSTANCES!


    Difference between Drugs & Poisons
    http://forums.steroid.com/showthread.php?t=317700


    Half-lives explained
    http://forums.steroid.com/showthread...inal+half+life


    DNP like Chemotherapy, can be a useful poison, but both are still POISONS
    http://forums.steroid.com/showthread.php?t=306144


    BE CAREFUL!

  16. #16
    magic32's Avatar
    magic32 is offline AR-Elite Hall of Famer
    Join Date
    Aug 2005
    Location
    Omnipresent
    Posts
    6,319
    Ahhhh...technically speaking, ALL low dose aas have on-book medicinal/therapeutic properties. If you'll recall that is their primary purpose.

    We use them off-book for the secondary, or maybe even tertiary, purpose of aesthetic and performance enhancement.

    I agree with the Var comments above, dosage should be contingent upon your goals, other compounds, and of course wallet.

    Again, Var (and most DHTs) can be run for looong periods (and are prescribed on-book that way), largely because they are extremely mild as evidenced by their low androgenic numbers.

    Generally at 20-80 mg, Var is optimally effective when administered twice daily (same for nearly all DHTs) due to the VERY short half-life. Tbol, 50-100 mg.
    Master Pai Mei of the White Lotus Clan



    My motto: SAFETY & RESPECT (for drugs and others).

    I AM NOT A SOURCE, I DO NOT GIVE OUT SOURCES, OR PROVIDE SOURCE CHECKS.
    I DO NOT SUPPORT ANY UGL's OR ANY ORGANIZATION DEALING WITH THE DISTRIBUTION OF ILLEGAL NARCOTICS/SUBSTANCES!


    Difference between Drugs & Poisons
    http://forums.steroid.com/showthread.php?t=317700


    Half-lives explained
    http://forums.steroid.com/showthread...inal+half+life


    DNP like Chemotherapy, can be a useful poison, but both are still POISONS
    http://forums.steroid.com/showthread.php?t=306144


    BE CAREFUL!

  17. #17
    Gallowmere's Avatar
    Gallowmere is offline Knowledgeable Member
    Join Date
    Aug 2017
    Posts
    2,378

    Anavar - &quot;little to no hepatotoxicity&quot;

    Quote Originally Posted by PHunter View Post
    So, the things ive read about Anadrol causing liver tumours is taken from this one case? Im keen to combine lower doses of Dbol with Anadrol to kickstart my next cycle but the stories of how toxic it is and how Anadro is known to cause tumours did worry me a little.
    From everything I have looked at (in medical/veterinary trials, not hit/hype pieces or shitty YouTube videos), yes. It was literally one guy, and they couldn’t even establish if it was related to the drug, or something else entirely that they couldn’t control for.
    Last edited by Gallowmere; 03-12-2020 at 04:45 AM.
    PHunter likes this.

  18. #18
    Ashop's Avatar
    Ashop is offline Anabolic Member
    Join Date
    Jun 2005
    Posts
    9,943
    ANAVAR and PRIMO are two of my favorite anabolics. Even at low dose results are exceptional.

  19. #19
    ChemyoDude is offline Junior Member
    Join Date
    Jan 2020
    Posts
    108
    Quote Originally Posted by Ashop View Post
    ANAVAR and PRIMO are two of my favorite anabolics. Even at low dose results are exceptional.
    IV run Var at 50mgs. I scored some pharma grade stuff gonna low dose it at 20mgs with 25mgs of Ostarine be over the summer.

    Sent from my Pixel 3a using Tapatalk

  20. #20
    bobspix is offline Associate Member
    Join Date
    Aug 2017
    Posts
    178
    I started out with headaches and massive sleepiness on anavar to now absolutely fully adapted at 50mg ED (20 in the start).
    How do you guys like to split the dosage? On 50mg, would it be better to do 30-20? Or 10-10-10-10-10?

  21. #21
    ChemyoDude is offline Junior Member
    Join Date
    Jan 2020
    Posts
    108
    Quote Originally Posted by bobspix View Post
    I started out with headaches and massive sleepiness on anavar to now absolutely fully adapted at 50mg ED (20 in the start).
    How do you guys like to split the dosage? On 50mg, would it be better to do 30-20? Or 10-10-10-10-10?
    I did 20/30

    Sent from my Pixel 3a using Tapatalk

Thread Information

Users Browsing this Thread

There are currently 1 users browsing this thread. (0 members and 1 guests)

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •