Gene Therapy/"Gene Doping" - would you try it?

[MaxiMyME]

If there was a myostatin inhibitor that was injected intramuscularly and showed good efficacy (80-90% inhibition) and good safety profiles in numerous organisms but was only tested on a few dozen humans. Would you try it?

Keeping in mind that myostatin null people live largely normal lives with only a mild amount if cardiac hypertrophy (which aas also cause). Short term use (up to months) of myostatin inhibitors is not associated with cardiac hypertrophy.

Also undetectable except through muscle biopsy.

Would you try it?

Yay or Nay

And if you are feeling generous with your time: why or why not?

Cost would be no more than a "fancy" aas like primobolan or Anavar.

[SampsonandDelilah]

Why are you pimping this so hard?

[MaxiMyME]

Why are you pimping this so hard?

Just trying to get feedback. Am I out of line? I can remove it if desired. Looked to remove it but not sure how or if I can.

Not trying to step on anyones toes or violate rules.

[wango]

Is this used medically for muscle wasting diseases or perhaps burn patients with loss of tissue? Just curious?

Are there any major body builders that will endorse this?

But me personally, or those I work with? I’d say no.

[tarmyg]

Trying to understand all the questions in there. What is the question behind the question?

[The Deadlifting Dog]

Why are you pimping this so hard?

He makes it.

[The Deadlifting Dog]

If there was a myostatin inhibitor that was injected intramuscularly and showed good efficacy (80-90% inhibition) and good safety profiles in numerous organisms but was only tested on a few dozen humans. Would you try it?

Keeping in mind that myostatin null people live largely normal lives with only a mild amount if cardiac hypertrophy (which aas also cause). Short term use (up to months) of myostatin inhibitors is not associated with cardiac hypertrophy.

Also undetectable except through muscle biopsy.

Would you try it?

Yay or Nay

And if you are feeling generous with your time: why or why not?

Cost would be no more than a "fancy" aas like primobolan or Anavar.

I would try it but I am very skeptical.

[DustMan]

I don't put anything inside of my body before I research it. If there isn't any research, it's not going in.

[SampsonandDelilah]

Trying to understand all the questions in there. What is the question behind the question?

Exactly.
I’m just trying to understand what your angle is. Feels like you have an agenda and I’m trying to figure it out. You’ve been so hot and heavy with this myostatin inhibitor rhetoric that it makes me question your why?

Feels like you parrot a bunch of pub Med articles on an AAS forum and are quick to ask others experiences, goals and stats. I’m not convinced you’re in the position to facilitate such discussions and question your “pedigree”. You’ve given some feedback and advice that is flat out wrong and frankly garbage. Specifically around the use of AI’s on cycle. Just some regurgitated bro science shit..


It feels like you think you can war plan at the pentagon because you’re a great Call of Duty player.

I’ve sat idly by watching it day by day and this poll shit finally pushed me over the top. What is it exactly you’re trying to gain or understand? Please don’t tell me it’s academic or to pacify some curiosity...

And what exactly is YOUR experience and why do you feel so qualified and entitled to offer and solicit such discussions.

I’m all for new blood and absolutely embrace all new folks here. I’ve read how much this place “means to you”. However, I’ve seen some flat out terrible advice given by you and a constant banging of this myostatin inhibitor drum that makes me call into question your whole facade...

[Ashop]

I don't put anything inside of my body before I research it. If there isn't any research, it's not going in.

Smart man!

[SampsonandDelilah]

He makes it.

Oh, so he’s on here promoting the value of MI because he has a bathtub full of it?

I don’t see a conflict of interest at all.

That coupled with the “sage” advice I’ve seen him handing out really makes me feel encouraged...

[Gallowmere]

Nope.
There’s really no point, given the objective of my training. Myostatin inhibition has a negative effect on ligaments and tendons, even in the animals that it works on. As such, it would most likely end up inducing injurious effect on actual strength training.

[Test Monsterone]

I don’t even do SARMS, so I would not try anything that hasn’t been verified to be relatively safe and effective.

On top of that I’m very skeptical about snake oil and bullshit. Everyone wants to make a quick buck.

[Honkey_Kong]

Unless maybe if you had some sort of genetic disease, you shouldn't mess with your genes. The body evolved the way it did for a reason. That's a recipe for something really bad to happen

[DustMan]

I don’t even do SARMS, so I would not try anything that hasn’t been verified to be relatively safe and effective.

On top of that I’m very skeptical about snake oil and bullshit. Everyone wants to make a quick buck.

Also you can't test if your sarms are real using $20 worth of supplies found on Amazon. I'm under the impression that more than 50% of sarm's are fake(or cheap replacements like Winny), and that they are almost all underweight.

I really wanted to try sarm's to be honest. Even after you realize that the majority of "studies" done on them are funded by the people producing and selling them they still look like a legit way increase gains with more tolerable sides. Hopefully in a few years we will have better data and a more reliable way of purchasing the real deal.

[Chark]

Oh, so he’s on here promoting the value of MI because he has a bathtub full of it?

I don’t see a conflict of interest at all.

That coupled with the “sage” advice I’ve seen him handing out really makes me feel encouraged...

He’s a molecular biologist suggesting doing things naturally first, using test only your first time, and injecting yourself with a peptide with no human trials a random stranger from the internet is peddling.

[MaxiMyME]

I will respectfully respond to your posts as time permits. Likely this weekend.

I appreciate all of your posts and feedback.

[MaxiMyME]

He’s a molecular biologist suggesting doing things naturally first, using test only your first time, and injecting yourself with a peptide with no human trials a random stranger from the internet is peddling.

"As noted by the facioscapulohumeral muscular dystrophy (FSHD) society, myostatin inhibitor clinical trials have begun on humans. The first trials on humans actually started in Feb, 2005. UPDATE: MYO-029 development has been dropped as it is safe but not effective.Nov 8, 2007
NextBigFuture.com › 2007/11
Myostatin inhibitor trials on humans | NextBigFuture.com"

This is just one from back in 2005. Other studies have shown mixed results in humans afflicted with various muscular dystrophies based on different criteria used to measure effectiveness.

In most cases they were deemed not effective enough to warrant continuing the development of the inhibitor.

The key parts there (with regard to the quoted post) are "human clinical trial" and "safe".

That was found by searching google for "myostatin inhibitor clinical trial"

I have researched myostatin inhibition for years. The science/research is there and it is sound. It is alot to express/document and digest. But it is there.

More to come on this n responding to posts.

And with regards to me being a stranger: get to know me. Nothing but air and opportunity. I'm open and will talk to anyone about virtually anything, anytime I am available.

[MaxiMyME]

I don’t even do SARMS, so I would not try anything that hasn’t been verified to be relatively safe and effective.

On top of that I’m very skeptical about snake oil and bullshit. Everyone wants to make a quick buck.

Hell there is one sarm that is sold and taken by many which has only been tested in vitro i.e. in glass.

Only research available on it is when it was used on muscle cells (I think myoblasts) in a dish!

And I am not looking to make money. It would be free to as many people as I can afford it to be for and then I would expect to be paid for my time and shipping, not trying to get rich or make astronomical profits. I have a primary job that pays enough to cover the bills.

It is in the name of science and knowledge, not greed.

That, and, whether people like it or agree with it or not, gene therapy/"gene doping" is the future of performance enhancement.

Aas will almost certainly still be a staple (especially for the amateur) but you could make gene therapies/substances that supplement natural genetics (rather than mimicking a natural substance) that accomplish the same, with less side effects. Test is a likely exception. And test affects your genes profoundly. Epigenetics. As important as traditional primary genes, are genes that affect the activation or modification of expression of genes.

There are more molecules (nucleic acids, co-factors, response-elements, etc) involved in regulation of genes than there are primary, identified protein-coding genes.

This makes sense when you consider the fact that before there were genes in their traditional sense, there was RNA that acted as enzymes. Later DNA evolved to make a superior form of storage and passing on of what would later become genes as we know them.

Maybe in an environment where broscience reigns supreme, there is less room for actual science. Want the real unbiased raw information? Turn to the source of all knowledge: scientific publications. It's what "writes" textbooks and changes their contents regularly. It's what is used to determine what is, and to designate information as, fact.

[Gallowmere]

Maybe in an environment where broscience reigns supreme, there is less room for actual science. Want the real unbiased raw information? Turn to the source of all knowledge: scientific publications. It's what "writes" textbooks and changes their contents regularly. It's what is used to determine what is, and to designate information as, fact.

The biggest hurdle for this is that 90% of what anyone here gives a shit about CAN’T be studies reliably in humans, because the IRB shuts shit down on a constant basis. Hell, I’m amazed that even the old 150/300/600mg test study didn’t get socked to the ground.
They regularly shoot down just about anything that has even a remote possibility of causing temporary harm in subjects. Now, when you start looking into the aspects of genetic modification in humans, it’s going to be several more decades of avoiding adverse effects in rats, then dogs, then primates before they even remotely consider allowing for actual trials on humans. Then, given how very different the genomes are between those tiers of mammals, we cannot extrapolate a damned thing from them onto people.

As such, the science of genetic modification in humans isn’t even a topic that can be discussed with any reliability until, at best, 2050. That is unless someone suddenly decides to inject trillions into the field, and straps a rocket ship to the whole process. This also assumes that “trillions” would be enough to get multiple labs working in tandem, etc., and best of luck with that clusterfuck.

[SampsonandDelilah]

Are you on fucking drugs? You really expect people to inject some home brew from an Internet forum guy that has been lurking around for a few weeks? I can’t tell if you’re audacious, hallucinating or just plain crazy.

I’m sure it’s fun to play “Tony Stark” in your parents basement but what you’re prostituting is not only egregious but dangerous and reckless.

Just because you parrot some google information and add your anecdotal spin doesn’t put you in any position to expect someone to actually buy in to this ridiculousness. This thread needs to be closed...period.

This isn’t a breeding ground for some pimp to hustle his theories and solicit customers...which is exactly what you’re doing.

In the name of science my ass. Even Kimbo thinks your weird

Your avi isn’t as inspiring as you may think and frankly I’m appalled at your audacity. How the fuck this is still open is beyond me...

The fact that it’s still open tells me admin, DD, AG and Cape must be enjoying this train wreck you’re steering. I tried to stay away and rarely do I “take the bait”, but after your ridiculous advice around AI’s on cycle coupled with this horse shit, I feel compelled to speak up. You obviously know where I stand and my track record here speaks for itself.

Internet gene therapy with an unknown, unqualified bathroom chemist is both hilarious and frightening.

[MaxiMyME]

The biggest hurdle for this is that 90% of what anyone here gives a shit about CAN’T be studies reliably in humans, because the IRB shuts shit down on a constant basis. Hell, I’m amazed that even the old 150/300/600mg test study didn’t get socked to the ground.
They regularly shoot down just about anything that has even a remote possibility of causing temporary harm in subjects. Now, when you start looking into the aspects of genetic modification in humans, it’s going to be several more decades of avoiding adverse effects in rats, then dogs, then primates before they even remotely consider allowing for actual trials on humans. Then, given how very different the genomes are between those tiers of mammals, we cannot extrapolate a damned thing from them onto people.

As such, the science of genetic modification in humans isn’t even a topic that can be discussed with any reliability until, at best, 2050. That is unless someone suddenly decides to inject trillions into the field, and straps a rocket ship to the whole process. This also assumes that “trillions” would be enough to get multiple labs working in tandem, etc., and best of luck with that clusterfuck.

This isnt genetic modification of the genome. It is gene therapy and myostatin inhibition can be done many ways (RNA interference, DNA plasmid, peptide/protein injection, etc.)

There have already been successful gene therapies done.

[MaxiMyME]

Are you on fucking drugs? You really expect people to inject some home brew from an Internet forum guy that has been lurking around for a few weeks? I can’t tell if you’re audacious, hallucinating or just plain crazy.

I’m sure it’s fun to play “Tony Stark” in your parents basement but what you’re prostituting is not only egregious but dangerous and reckless.

Just because you parrot some google information and add your anecdotal spin doesn’t put you in any position to expect someone to actually buy in to this ridiculousness. This thread needs to be closed...period.

This isn’t a breeding ground for some pimp to hustle his theories and solicit customers...which is exactly what you’re doing.

In the name of science my ass. Even Kimbo thinks your weird

Your avi isn’t as inspiring as you may think and frankly I’m appalled at your audacity. How the fuck this is still open is beyond me...

The fact that it’s still open tells me admin, DD, AG and Cape must be enjoying this train wreck you’re steering. I tried to stay away and rarely do I “take the bait”, but after your ridiculous advice around AI’s on cycle coupled with this horse shit, I feel compelled to speak up. You obviously know where I stand and my track record here speaks for itself.

Internet gene therapy with an unknown, unqualified bathroom chemist is both hilarious and frightening.

I am not asking and have not asked anyone on this forum to use this.

I am not offering and have not offered it to anyone on this forum.

I simply want from this forum people's opinions on whether they would try it or not. And any other feedback they have, including yours.

Your point is obvious, well-stated and noted.

I appreciate all feedback, positive, negative and neutral.

And I have no problem ignoring what is personal to me and not on the topic, which is would you try gene therapy/gene doping.

Peace be with and within you.

[SampsonandDelilah]

I made it personal, I apologize that my irritation with you caused me to lash out.
I’m usually better than that. As I said, I find this dangerous.

However....

And I am not looking to make money. It would be free to as many people as I can afford it to be for and then I would expect to be paid for my time and shipping, not trying to get rich or make astronomical profits. I have a primary job that pays enough to cover the bills.

This makes me have to disagree that you never “offered it up to anyone”.

[MaxiMyME]

I made it personal, I apologize that my irritation with you caused me to lash out.
I’m usually better than that. As I said, I find this dangerous.

However....

And I am not looking to make money. It would be free to as many people as I can afford it to be for and then I would expect to be paid for my time and shipping, not trying to get rich or make astronomical profits. I have a primary job that pays enough to cover the bills.

This makes me have to disagree that you never “offered it up to anyone”.

Those words did not pertain specifically to people on this forum. It was a general statement.