Nolva causing gyno?

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11-02-2003, 02:23 PM
bigdave91

Nolva causing gyno?

I started taking 20mg of Nolvadex yesterday and my nipples are tingling every now and then and my left nip is a little bit more sensitive!
Why might this be? i havent started my steroid cycle yet. i dont start til tomorrow.

dave
11-02-2003, 02:25 PM
BDTR

Its in your head.
11-02-2003, 02:28 PM
Pheedno

in your head, half-life of Nolva is 5-7 days. It takes roughly 5x that to reach steady plasma levels. The on;y way to get gyno from nolva(indirectly) is from estrogen rebound, and you havn't been taking a high enough dose, or for a length of time that would render that possibility
11-02-2003, 02:34 PM
bigdave91

so iof i started the nolva yesterday it wont kick in properly until thursday or friday?
I take my first sust injection tommorrow and the second on thurs 250mg each time, does that mean that im not going to be protected from gyno for 2-3 days?

Dave
11-02-2003, 02:37 PM
BDTR

You're fine lol.
11-02-2003, 02:38 PM
Pheedno

You'll be fine. It only takes hours for activation in the body, but it takes around 4-5x the half life to reach a steady blood plasma level.
11-02-2003, 04:34 PM
bigdave91

lol
thanks guys!
:lol:
11-02-2003, 05:22 PM
LORDBLiTZ

Quote:

Originally Posted by Pheedno

in your head, half-life of Nolva is 5-7 days. It takes roughly 5x that to reach steady plasma levels. The on;y way to get gyno from nolva(indirectly) is from estrogen rebound, and you havn't been taking a high enough dose, or for a length of time that would render that possibility

Well nolva is a synthetic estrogen. This is how it finds the estrogen receptor to block it in the first place. Could the small amount of synthetic estrogen used to find the ER be enough to cause it to be a little bit more sensitive?
11-03-2003, 09:31 AM
Pheedno

Quote:

Originally Posted by LORDBLiTZ

Well nolva is a synthetic estrogen. This is how it finds the estrogen receptor to block it in the first place. Could the small amount of synthetic estrogen used to find the ER be enough to cause it to be a little bit more sensitive?

Only if the persons natural Estrogen production was really low. Then the Nolva would have a estrogen agonist effect. Thats why it's used for women going through menopause. Their estro production is low to nothing, and the tamox binds to empty receptors and mimicks estrogen(this helps in relieving hot flashes and other symtpoms).

A person who had regular estrogen production(even a male) would see a decrease in natural estrogen binding.
11-03-2003, 09:36 AM
TheMudMan

Quote:

Originally Posted by bigdave91

I started taking 20mg of Nolvadex yesterday and my nipples are tingling every now and then and my left nip is a little bit more sensitive!
Why might this be? i havent started my steroid cycle yet. i dont start til tomorrow.

dave

I agree with these guys that the signs are in your head. Are you doing anything different like tanning, or did you shave your chest?
11-03-2003, 10:57 AM
bigdave91

No nothing different.

I havent felt it since i posted this thread. so i think its in my head.

Dave
11-03-2003, 10:59 AM
TheMudMan

Quote:

Originally Posted by bigdave91

No nothing different.

I havent felt it since i posted this thread. so i think its in my head.

Dave

:lol: Maybe that's all you needed.............. Good luck bro on your cycle.
11-03-2003, 07:38 PM
LORDBLiTZ

Quote:

Originally Posted by Pheedno

Only if the persons natural Estrogen production was really low. Then the Nolva would have a estrogen agonist effect. Thats why it's used for women going through menopause. Their estro production is low to nothing, and the tamox binds to empty receptors and mimicks estrogen(this helps in relieving hot flashes and other symtpoms).

A person who had regular estrogen production(even a male) would see a decrease in natural estrogen binding.

Awesome! Thanks man.