Slin during PCT.....please help!

[pmacdona51]

I am approachin my PCT and am gonna do a slin cycle (4weeks) during my PCT. I am going to start at a low dose as this is my first time using slin. I am thinking 2IU when i wake up and 2IU post workout. Then increasing by 1IU every day to see my sensitivity. I have a couple of questions. First, at these low doses what amount of carbs/protien (I will be using 10g of creatine everytime) should i consume post slin shot. And as well what signs of sensitivity should i look out for as i increase my dosage. THanx

[JohnnyB]

This will help

Insulin: The Most Anabolic Hormone
by Grendel

Look back through picture archives of bodybuilding and you will be struck by a startling fact. In the last half-decade bodybuilders have been getting much larger much quicker. Certain professionals have added twenty pounds to their contest weight in one season, after having seemingly reached a plateau. The bodybuilding audience loves to hear that this weight gain is due to some secret drug or some newly discovered gene therapy. Elaborate theories are developed to explain these rapid weight gains and the professionals themselves are not helpful; they claim that it's the new X-brand supplement that's doing it and leave it at that.

The truth is that bodybuilders have discovered the most anabolic hormone produced by the body, insulin. Additionally, insulin has the benefit of being not only legal and over the counter in most states, but it is very cheap. A bottle costs less then thirty dollars and there is no need to worry about counterfeits. By correctly using insulin, in conjunction with human growth hormone and anabolic steroids, modern professionals have added pounds of mass onto seemingly stagnant physiques.

This chapter will give a brief overview of insulin and the methods by which its anabolic action is exerted. We will outline how to correctly and safely use insulin both to gain size and to prepare for a contest (or simply diet).

Insulin: The Overview
Insulin is a peptide hormone, secreted by the pancreatic islets of Langerhans. Insulin promotes glucose utilization, protein synthesis, and regulates the metabolism of sugar. Insulin travels until it reaches receptor sites on cells. At these sites insulin facilitates the transport of glucose and amino acids across the cell membrane to be used inside the cell for energy and protein synthesis. This is insulin's anabolic effect, not only in super-saturating the cells with nutrients, but also helping to volumize the cell.

Insulin Safety:
There are significant risks that accompany the use of insulin. The greatest risk is an over-dose of insulin, which leads to hypoglycemic shock. This is not an overdose in the typical sense of the word; in this case it means that too much insulin was administered for the amount of glucose in the bloodstream. To this end, it is important to choose the correct type of insulin and to know when it peaks and the effective period of action of the drug in your body. This information is provided later in this chapter.

The symptoms of insulin shock are easy to recognize.
Distress is relatively rapid, usually in a matter of minutes.
Hunger.
Sweating.
Cold, clammy feeling.
Paleness.
Trembling, anxiety.
Rapid heartbeat.
Feeling of weakness or faintness.
Irritability and change in mood or personality.
Loss of consciousness.

Treatment:
Feed the person a source of quickly absorbed sugar. If the person is conscious, table sugar, fruit juice, honey, a non-diet soft drink, or any other available sugar source will do. If the person is unconscious, do not try to force sugar or liquid down his throat. Honey, granulated sugar, or a special capsule (such as D-glucose) containing concentrated sugars, which some diabetics carry, can be carefully placed under the tongue where it is absorbed into the body. However, this may be difficult to do.
There is another rapid form of intervention that anyone using insulin should know about; a glucagon pen. Injectable glucagon is a hormone, normally produced in the pancreas, which has effects opposite to those of insulin. It is commonly used to treat hypoglycemia or low blood sugar. It may also be used to relax parts of the gastrointestinal tract for certain examinations. It is not a controlled substance. In the event of the onset of hypoglycemia, this emergency injection will pull your blood sugar back up. If you are using insulin, you should have one of these pens with you at all times.

Take the person to a hospital emergency room as quickly as possible. Severe insulin reactions can be fatal. Do not be afraid of getting into "trouble", the use of insulin is legal. You will certainly get a lecture about how crazy it is to use insulin, but you will not be arrested or detained in anyway.

It is extremely important to have someone who you can trust monitor you when you are using insulin. They should be aware of the signs of insulin shock as well as the course of action to follow in the event that you do slip into a hypoglycemic state. Some insulin users will go so far as to purchase a medic alert bracelet that indicates them as a diabetic in the even that they pass out in public.

During a bulking phase, when calorie intake is deliberately high, insulin shock is not likely to be a problem assuming that post injection nutrition is precise (as outlined later in the chapter). In the even that you begin to feel any of the above symptoms immediately begin to consume the most simple sugars you can find, particularly look for glucose polymers and dextrose. Avoid fructose, as it is ineffective at raising blood sugar levels rapidly.
In the even that you are using insulin in dieting, do not be afraid to "blow your diet" by eating candy if you feel your blood sugar getting dangerously low. Your diet is not worth your life.

Types of Insulin:
There are three important characteristics that differentiate the available types of modern insulin. To properly use insulin in bodybuilding it is important to know the following characteristics:
Onset:
the time it takes the injected insulin to reach the blood stream and begin to work.
Peak:
the time period in which the insulin is working it's hardest to lower the blood sugar.
Duration:
the length of time the insulin will be working in the bloodstream. It is important to remember that insulin is an indiscriminate storage hormone. It doesn't care if its storing fat or glucose. Therefore fat intake should be as low as possible during the effective period of the insulin in the body. This will help prevent excessive fat gain.

For bodybuilding purposes we will only be concerned with three types of insulin; Humalin "R", Humalin "N" and Humalog are the most useful types of insulin. The other varieties are mixes of the above types in set ratios.
Humalin "N" is the longest acting insulin; it is active in the body for 24 hours.

Additionally, it peaks several times throughout the day. Humalin "N' is useful in the high calorie off-season when there will always be an abundant supply of glucose. However, even the most dedicated bodybuilder who is eating many small meals may run into serious trouble in the insulin peak corresponds to a period of low blood sugar. Also, the long duration of Humalin "N' means that the bodybuilder must adhere to a low fat diet throughout the day, which is incongruously with the eating necessary to achieve brutal size.

Humalin "R" is known as the rapid insulin. The manufacturers claim that this type of insulin is active in the body for up to six hours; in reality it's closer to four and a half hours. The onset time of "R" is roughly thirty minutes and the drug peaks in one and a half to two and a half hours after injection.

Humalog is the fastest acting insulin. It has duration of about 2 hours, peaks in fifteen minutes, and is ideal for bodybuilding purposes because it is out of the body quickly. The speed at which Humalog works is beneficial because it allows us more precise control and lets us know exactly when food needs to be consumed.

Insulin Injection Procedure:
Insulin can be injected intravenously, intramuscularly, or subcutaneously. Injection insulin into the veins is creepy, but safe. However, it is not necessary to do this, as injection insulin into muscle or under the skin is just as effective.

The injection site, exercise, and the accuracy of the dosage measurement, the depth of injection and by environmental temperatures, can affect insulin absorption. To obtain consistency in daily insulin absorption and action, you should vary injection sites within the same anatomical region. The abdomen provides an excellent area for consistent absorption of insulin, whereas the leg and arm areas are often affected more by exercise.

Repeated injection in the same area may cause a delay in absorption whereas massaging the site of injection may lead to an increased rate of absorption. Insulin should be injected at a 90-degree angle using an insulin syringe (25 unit, 30 unit, 50 unit, or 100 unit size) or with an insulin pen. If redness, pain, or lumps are noted at the injection site, this area should be avoided until the problem goes away.

Be sure to follow proper sterilization procedures. Wipe down the injection area with alcohol. The insulin needle is very thin so bleeding should be minimal. However, press a swab of cotton soaked in alcohol over the injection site after you withdraw the needle. This will protect almost entirely against infection.

An increase in blood flow to an injection site will increase the rate that insulin is absorbed. So, exercise will cause insulin to be absorbed more rapidly, because blood flow has increased to the exerted muscle groups. You will need to either inject less insulin or eat more carbohydrates after exercise. Rubbing the injected area increases blood flow, and hence, absorption.

Post Injection Meals and Supplements:
Depending on the onset time of the insulin type you are using you have varying lengths of time in which to ingest the post-insulin meal. Generally your post insulin meals should follow these guidelines.
60-80 grams of a good quality protein powder. Whey protein is ideal. This is taken immediately after the injection.
7 grams of simple carbohydrates (not fructose as it does not raise blood sugar quickly enough) per IU of insulin injected. Every 15-20 minutes after the first shot, take a few glucose tablets. This is will increase the amount of glucose available to your body for storage.
200 mg of chromium picolinate (this is optional).
200 mg of lipoic acid (this is optional).
30 mg vanadyl sulfate (this is optional).
2000 mg of hydroxy citric acid (this is optional).
5-7 grams of creatine monohydrate. This is crucial.
5-7 grams of glutamine powder. This is also crucial.

The total amount of insulin that you will be using daily is roughly 15-45 IUs depending on how many carbohydrates you can eat that day. During dieting periods, the total amount of insulin will be greatly reduced.

Typically, three injections of insulin are used daily. The first is taken immediately upon awaking; this is an appropriate time to use the Humalin "R". The second shot is taken mid-day and Humalog is recommended. The last injection is taken immediately after the workout of the day. If you are doing a double split training program, then take one shot after each workout and adjust your other injection accordingly. Do not take an injection too late at night; you want to be able to stay awake through the entire period of action so you can monitor yourself for signs of low blood sugar.

Anyone who is going to use insulin should take some time to familiarize him or herself with the glycemic index. The glycemic index is a ranking of foods based on how they effect the body's blood sugar levels. There are many resources that provide elaborate listing of many types of foods including fast foods. For our purposes it is merely important to identify the foods with high glycemic index scores to consume with the insulin injection. Below is a list of foods (or sugars) that scored very highly on the glycemic index.

Whole Foods or Candies
Jelly Beans
Dates Sugar types
(in ascending order; Maltose elevates blood sugar the most)
Lactose
Honey
High fructose corn syrup
Glucose
Glucose tablets
Maltodextrin
Maltose

Conclusion
For many, insulin may seem like the perfect bodybuilding drug. It's legal, cheap, effective, and easy to obtain. However, the decision to use insulin is not one that can be made lightly. At worst, the misuse or abuse of anabolic steroids will probably result in no more than elevated liver enzymes and a host of undesirable cosmetic side effects. Improper use of insulin will result in much more serious consequences, including death. Bodybuilders must first ask themselves if they possess the necessary maturity and intelligence to responsibly use this hormone. Look before you leap my friends.

JohnnyB

[revie]

sugars (dextrose) needs to be taken post a insulin injection, with humalog, almost instantly foods must be taken. simple carbs mixed with sugars and high protein foods will be best.
creatine will increase insulin sensitivity

[JohnnyB]

I have to look it up but I remember read a study that show slin help recover test or something like that.

JohnnyB

[JohnnyB]

Posted ny Drveejay11

Insulin enhancement of luteinizing hormone and follicle-stimulating hormone release by cultured pituitary cells.

Adashi EY, Hsueh AJ, Yen SS.

The role of insulin in the regulation of basal and gonadotropin-releasing hormone (GnRH)-stimulated release of LH and FSH was investigated in vitro using primary cultures of rat anterior pituitary cells from adult ovariectomized rats. Anterior pituitary cells were incubated for 2 days in the presence or absence of insulin in a serum-free medium. At the end of the insulin treatment, the cells were washed and reincubated in the presence or absence of GnRH, and the LH and FSH released into the medium were measured by RIA. Treatment with insulin (1.0 microgram/ml) for 2 days resulted in significant increases in both the basal and the maximal release of LH and FSH, as well as a 3.2- and 6.3-fold decrease in the ED50 values for GnRH in terms of LH and FSH release, respectively. Treatment with increasing concentrations (0.1-10,000 ng/ml) of insulin, led to a dose-dependent increase in the GnRH (3 X 10(-10) M)-stimulated release of both LH and FSH. This effect of insulin was significant (P less than 0.05) at a physiological concentration of 1 ng/ml (24 microU/ml) with an ED50 value of 40 ng/ml. Increasing duration of exposure to insulin resulted in time-dependent increases in the GnRH (3 X 10(-10) M)-stimulated release of LH, becoming significant at 24 h with maximal enhancement observed by 48 h. The effect of insulin was specific; epidermal or fibroblast growth factor did not enhance LH release. The augmenting effect of insulin was not associated with cellular proliferation or an overall change in protein or LH synthesis. Furthermore, the effect of insulin was independent of the ambient glucose concentration. Insulin was, however, without effect on gonadotrophs cultured in a serum-supplemented medium. Our findings suggest that the gonadotroph constitutes a target cell of insulin and that insulin may act directly on the anterior pituitary in the regulation of gonadotropin release.

JohnnyB

[majorpecs]

Interesting.....so does this mean that slin would be a good contribution to PCT? I know your body is very catabolic during pct and the AM slin would help counter that, but it if helps with the gonadotropin release sounds like you may be able to kill 2 birds with one stone. I'm fixing to come off and I've been on test for about 1.5 years now. Kinda worried about it.

[einstein1905]

"Insulin was, however, without effect on gonadotrophs cultured in a serum-supplemented medium."

The study is very interesting, and I have no idea what possessed them to even consider looking at such a thing. The above highlighted line is very important though. These assays were done in vitro with pituitary cells, which is fine. However, the conditions were a "serum-free" environment, which means the majority of components circulating in the bloodstream were absent from this experiment.....when they reintroduced serum and tried the experiment, they did not see the same results. What components act to negate the effects of insulin on GnRH sensitivity....I have no idea

[JohnnyB]

"Insulin was, however, without effect on gonadotrophs cultured in a serum-supplemented medium."

That sux

JohnnyB

[ColdSore]

Interesting.....so does this mean that slin would be a good contribution to PCT? I know your body is very catabolic during pct and the AM slin would help counter that, but it if helps with the gonadotropin release sounds like you may be able to kill 2 birds with one stone. I'm fixing to come off and I've been on test for about 1.5 years now. Kinda worried about it.

thats a good point...in pct would it be better to take say 4 iu's in the am and 6ius PWO???

[Mallet]

thats a good point...in pct would it be better to take say 4 iu's in the am and 6ius PWO???

10/10...8/8...6/6...no need to change up the dosage IMO, I've used slin during pct's before and i will continue to do it everytime. Definately held onto more muscle mass with the addition of slin, as well I gained a few lbs too.

[ColdSore]

10/10...8/8...6/6...no need to change up the dosage IMO, I've used slin during pct's before and i will continue to do it everytime. Definately held onto more muscle mass with the addition of slin, as well I gained a few lbs too.

cool...well i was thinking 10 ius per day...so 5/5 would be better...

how do you do your AM shots???...as far as nutrition and diet go, and timeing???

[Mallet]

cool...well i was thinking 10 ius per day...so 5/5 would be better...

how do you do your AM shots???...as far as nutrition and diet go, and timeing???

My am nutrition is exactly like my PWO intake, i take full advantage of the disposal properties...fasting glucose isn't that much different from PWO glucose levels, basically your in a glycogen deficit and this is the only time when slin has a destinct advantage at shuttling nutrients.

[ColdSore]

My am nutrition is exactly like my PWO intake, i take full advantage of the disposal properties...fasting glucose isn't that much different from PWO glucose levels, basically your in a glycogen deficit and this is the only time when slin has a destinct advantage at shuttling nutrients.

how long after that 1st real food meal of pro/carb do you wait to have a pro/fat meal?

[Mallet]

how long after that 1st real food meal of pro/carb do you wait to have a pro/fat meal?

If your going IM then 3 hours, if your going subQ then 3.5 hours..I have found the duration of effect to be longer than what has been suggested by the manufacturers.

[ColdSore]

If your going IM then 3 hours, if your going subQ then 3.5 hours..I have found the duration of effect to be longer than what has been suggested by the manufacturers.

perfect!...im getting this **** down now...

i was planning on going protein and low GI carbs (oatmeal, or maltomeal) 3-3.5 hours after my 60-80 grams of whey intake...