I know this has been a debate before, but what do some of you think about this?
Luckily for us, Nolva has estrogenic effects on bones (meaning it increases their density), and blood lipids -
meaning it lowers cholesterol-, (4)(5)as well as preventing gynocomastia
by preventing estrogen gene transcription in breast tissue. However, it
acts as an anti-estrogen in the pituitary, thus increasing LH and FSH,
which results in an increase in testosterone. 20mgs of Nolvadex will raise
your testosterone levels about 150% (6)...Nolvadex actually has quite a
few applications for the steroid using athlete. First and foremost, it’s
most common use is for the prevention of gynocomastia. Nolvadex does this
by actually competing for the receptor site in breast tissue, and binding
to it. Thus, we can safely say that the effect of tamoxifen is through
estrogen receptor blockade of breast tissue (7).
Estrogen is also important for a properly functioning immune system, and
not only that, but your lipid profile (both HDL and LDL) should also show
marked improvement with administration of tamoxifen (34).
Nolvadex also has some important features for the steroid using athlete.
In hypogonadic and infertile men given nolvadex, increases in the serum
levels of LH, FSH, and most importantly, testosterone were all observed
(35)It can also block a bit of estrogen in the pituitary, which is a great
benefit when used with HCG (more on that later) (36)(37). The increase in
testosterone Nolvadex can give someone with a dysfunctional is basically
that 20mgs of Nolvadex will raise your testosterone levels about 150%
(6)...Why don’t we use Clomid, another SERM? Well, basically because it
takes much more to do the same thing. In comparison, it would require
150mgs of Clomid to accomplish that type of elevation in testosterone, but
Nolvadex also has the added benefit of significantly increasing the LH
(Leutenizing Hormone) response to LHRH (LH-releasing hormone) (6). This
most likely indicates some kind of upregulation of the LH-receptors due to
the anti-estrogenic effect Nolvadex has at the pituitary. Although both
Nolvadex and Clomid are both SERMs, they are actually quite different. As
you already know, Nolvadex is highly anti-estrogenic at the hypothalamus
and pituitary, while Clomid exhibits weak estrogenic activity at the
pituitary (7), which as you can guess, is less than ideal. It should be
avoided for the PCT I’m suggesting…and in fact, avoided in general…it’s
simply not as good as Nolvadex.
Need I even add that the 150mgs of Clomid you need to get the hormonal
increase experienced with 20mgs of Nolvadex is much more expensive? So
lets dump the Clomid…and no, using it along with Nolvadex will provide
no “synergy” that I’ve ever seen in any relevant study."
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