period pill MIDOL

[gabriel595]

i know this is a weird question, but yesterday i was looking at my sister's pills (no i'm not gay haha) and saw that they only had acetaminophene wich is a pain reliever, caffeine, and a couple diuretics, that's it. in the box says they are for pain and BLOATING. so i figured they can help in reducing water retention to a minimun without using excessive anti-estrogens or drugs. just a wierd opinion cause i wont use them

[marcus300]

i know this is a weird question, but yesterday i was looking at my sister's pills (no i'm not gay haha) and saw that they only had acetaminophene wich is a pain reliever, caffeine, and a couple diuretics, that's it. in the box says they are for pain and BLOATING. so i figured they can help in reducing water retention to a minimun without using excessive anti-estrogens or drugs. just a wierd opinion cause i wont use them

[gabriel595]

hahahahah i knew this would happen, it's just a question if it can keep women from bloating i guess it will with men too...just my 2 cents

[doghunter]

aaahhh i dont think so really , not sure why not because i have not put any thought into it but i just think its different because its a bloated feeling that woman get i think the pills take that feeling away thats all . not sure

[gabriel595]

yes i was thinking the same right now, maybe another kind of diuretic will do the job better.

[Warrior]

How about simply drinking more water during the day and other basic dietary manipulations? Don't get caught up in too many pills... it is easy to do - every once in awhile you have to ask yourself if something is really necessary for your goal - especially when trying to avoid negative interactions between two compounds and errring on the side of benefits and not risks.

And weren't the latest abstracts (over the last year or so) reporting Acetaminophene has a negative impact on protein synthesis?

[AnabolicAndre]

And weren't the latest abstracts (over the last year or so) reporting Acetaminophene has a negative impact on protein synthesis?

I wont go there it seems everytime I try to explain this to people it turns in to a three page thread on how thats impossible.

[BigJohnE]

I agree with not getting too "pill happy" for everything, but the OTC product called "diurex" (found near the midol) that contains only 50mg of Pamabrom, which is a decent enough diuretic along with plenty of water and a cut in sodium intake does have a decent effect without being too harsh while on cycle. Just my .02

[Warrior]

I wont go there it seems everytime I try to explain this to people it turns in to a three page thread on how thats impossible.

Really? Here are results after a quick PubMed search...

Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis.

Trappe TA, White F, Lambert CP, Cesar D, Hellerstein M, Evans WJ.

Donald W. Reynolds Center on Aging, Department of Geriatrics, University of Arkansas for Medical Sciences, and the Central Arkansas Veterans HealthCare System, Little Rock, Arkansas 72205, USA. [email protected]

We examined the effect of two commonly consumed over-the-counter analgesics, ibuprofen and acetaminophen, on muscle protein synthesis and soreness after high-intensity eccentric resistance exercise. Twenty-four males (25 +/- 3 yr, 180 +/- 6 cm, 81 +/- 6 kg, and 17 +/- 8% body fat) were assigned to one of three groups that received either the maximal over-the-counter dose of ibuprofen (IBU; 1,200 mg/day), acetaminophen (ACET; 4,000 mg/day), or a placebo (PLA) after 10-14 sets of 10 eccentric repetitions at 120% of concentric one-repetition maximum with the knee extensors. Postexercise (24 h) skeletal muscle fractional synthesis rate (FSR) was increased 76 +/- 19% (P < 0.05) in PLA (0.058 +/- 0.012%/h) and was unchanged (P > 0.05) in IBU (35 +/- 21%; 0.021 +/- 0.014%/h) and ACET (22 +/- 23%; 0.010 +/- 0.019%/h). Neither drug had any influence on whole body protein breakdown, as measured by rate of phenylalanine appearance, on serum creatine kinase, or on rating of perceived muscle soreness compared with PLA. These results suggest that over-the-counter doses of both ibuprofen and acetaminophen suppress the protein synthesis response in skeletal muscle after eccentric resistance exercise. Thus these two analgesics may work through a common mechanism to influence protein metabolism in skeletal muscle.


Skeletal muscle PGF(2)(alpha) and PGE(2) in response to eccentric resistance exercise: influence of ibuprofen acetaminophen.

Trappe TA, Fluckey JD, White F, Lambert CP, Evans WJ.

Nutrition, Metabolism, and Exercise Laboratory, Donald W. Reynolds Center on Aging, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA. [email protected]

PGs have been shown to modulate skeletal muscle protein metabolism as well as inflammation and pain. In nonskeletal muscle tissues, the over the counter analgesic drugs ibuprofen and acetaminophen function through suppression of PG synthesis. We previously reported that ibuprofen and acetaminophen inhibit the normal increase in skeletal muscle protein synthesis after high intensity eccentric resistance exercise. The current study examined skeletal muscle PG levels in the same subjects to further investigate the mechanisms of action of these drugs in exercised skeletal muscle. Twenty-four males (25 +/- 3 yr) were assigned to 3 groups that received the maximal over the counter dose of ibuprofen (1200 mg/d), acetaminophen (4000 mg/d), or a placebo after 10-14 sets of 10 eccentric repetitions at 120% of concentric 1 repetition maximum using the knee extensors. Preexercise and 24 h postexercise biopsies of the vastus lateralis revealed that the exercise-induced change in PGF(2alpha) in the placebo group (77%) was significantly different (P < 0.05) from those in the ibuprofen (-1%) and acetaminophen (-14%) groups. However, the exercise-induced change in PGE(2) in the placebo group (64%) was only significantly different (P < 0.05) from that in the acetaminophen group (-16%). The exercise-induced changes in PGF(2alpha) and PGE(2) were not different between the ibuprofen and acetaminophen groups. These results suggest that ibuprofen and acetaminophen have a comparable effect on suppressing the normal increase in PGF(2alpha) in human skeletal muscle after eccentric resistance exercise, which may profoundly influence the anabolic response of muscle to this form of exercise.