GH ? Mods, Vets, members need imput seriously

[ItalianMuscle]

Check this out please guys , Opionions needed..

I have had a benign non cancer Tumor smaller than a dime for 20yrs now had 1 operation when i was 15yr old because it grew some what.

I started My gear at 20yrs old and now i'm 28yrs old and done alot of juice almost from a -z and NO problems with tumor cause i get it checed every year never grows ..

I never did GH and i have few kits kinda hesitant but just want get some imput on what u thin if tumor will grow.. i'm not scared to do it but want imput..

Please vets, mods, members give me ur opinion.. i don't thin it would i mean i been on gear 8yrs and NOTHING never grew. I alays now there is chance.

[IBdmfkr]

Why would you even chance it?

[Gear]

I wouldn't do it no matter what anyone says.

-Gear

[Xtralarg]

Agree with above posts.

[t-gunz]

yeah not worth trying IMHO

[stocky121]

i wouldent try it nope

[Gear]

Wether GH will have a negative effect or not I think you pretty much got your answer mate.

-Gear

[Benches505]

Sounds like Russian roulette to me. forget about GH.

[BG]

Thought shouldnt have even crossed your mind.

[marcus300]

Don't do it, health is everything its not worth the risk

[THE JU-ICE]

Any brand of Gh website you go to always has a caution and says do not use if you have or have had any tumors.

[ItalianMuscle]

wow so may negative opinions..

Come on we are all hook on gear and want be bigger and be competitive in the gym , I have not read anywhere that GH will make tumor grow remember it is not canceres and all a benign tumor is a small hard ball of fluid.

Has anyone have any real hard evidence that GH will make it grow ?

We wall play russian roullete with gear and GH, slin and so on and we now it ain't good for our bodies..

[Gear]

wow so may negative opinions..

Come on we are all hook on gear and want be bigger and be competitive in the gym , I have not read anywhere that GH will make tumor grow remember it is not canceres and all a benign tumor is a small hard ball of fluid.

Has anyone have any real hard evidence that GH will make it grow ?

We wall play russian roullete with gear and GH, slin and so on and we now it ain't good for our bodies..

I don't know about you, but I am $hit scared when it comes to bad health. And even if my doc said to me "yes you can do it" I still wouldn't do it because you just never know. Yes we all want to get bigger and better but your life and health comes first bro. And yes you're right, none of these compounds we are using are good for us, but when you have a health issue such as what you have then you have to remember you are in a different boat to us mate.

Do yourself a favour and stay of the drugs period.

-Gear

[IBdmfkr]

When I was a little younger I took GH/Slin/higher doses of gear etc and didn't really think twice but now I only take Test on cycle and never exceed a gram/wk and still make consistant gains in the gym.
Living a healthy lifestyle (eating/training) are the most important things, yea I could probably be 10-20lbs heavier if I used those compounds but the possibilities of negative sides now and later on in life just isn't worth being absolutely huge.

Gotta think about the future and how what you do now might affect you later in life.

[stocky121]

When I was a little younger I took GH/Slin/higher doses of gear etc and didn't really think twice but now I only take Test on cycle and never exceed a gram/wk and still make consistant gains in the gym.
Living a healthy lifestyle (eating/training) are the most important things, yea I could probably be 10-20lbs heavier if I used those compounds but the possibilities of negative sides now and later on in life just isn't worth being absolutely huge.

Gotta think about the future and how what you do now might affect you later in life.

couldent have said it better my friend

[ItalianMuscle]

So all of you saying No GH ? not if with low iu a day ?

I have had no sides from gear and i done alot of gear over last
7 8 yrs, and what i have never grew and isn't a concern.
I don't even think about it.

Is there any facts that GH makes it grow ?

They say gear causes Benign tumors but hey i have one size of dot
since i been on 8yrs and never ever grow and i get mri every year.

[Xtralarg]

It looks like you want someone to just to agree with you so you feel better about doing it. Some very knowledgabe guys have taken the time to reply in this thread and all of them have warned you against it, take heed.

[ItalianMuscle]

And I appreciate it really but i'm just saying if i been on gear and it hasn't grown in last 8yrs , why would GH make it grow i just wanting to see some facts . Thats all..

I know alot guys on here are very experienced , but have u ever heard or now a person or even read that had non growing benign tumor and gh made it grow

[IBdmfkr]

Why not get the tumor removed?

What do you think GH will do for you that a properly setup diet and training program can't?

[BG]

Here you go, food for thought.....


Development of a polyclonal antiserum for the
detection of the isoforms of the receptors for human
growth hormone-releasing hormone on tumors
Gabor L. Toller*†‡§, Judit E. Horvath*†‡§, Andrew V. Schally*†¶, Gabor Halmos*†, Jozsef L. Varga*†, Kate Groot*†,
David Chism*†, and Marta Zarandi*†

*Endocrine, Polypeptide, and Cancer Institute, Veterans Affairs Medical Center, New Orleans, LA 70112-1262; and †***artment of Medicine, Section of
Experimental Medicine, Tulane University School of Medicine, New Orleans, LA 70112
Contributed by Andrew V. Schally, September 8, 2004
Antagonists of growth hormone-releasing hormone (GHRH) inhibit
the growth of various human cancers by multiple mechanisms,
which include direct effects on tumor cells through the splice
variants (SV) of the GHRH receptor. Our findings suggest that the
tumoral protein encoded by SV 1 (SV1) is a likely functional
receptor. The aim of this study was to develop a polyclonal
antiserum against a polypeptide analog of segment 1–25 of the
putative SV1 receptor protein. Rabbits were immunized with [Ala-
23]SV1 (1–25)-Tyr-26-Cys-27-NH2 as a hapten, conjugated to BSA or
keyhole limpet hemocyanin. The antisera thus generated were
evaluated by RIA for binding to the radiolabeled hapten. The
specificity and sensitivity of the antisera were studied on xenografts
of RL and HT human non-Hodgkin’s lymphomas. The sera
raised against keyhole limpet hemocyanin-SV1 hapten, showed
binding values of 50–75% at a 1:56,000 dilution. In Western blot
analyses, the purified polyclonal antibody recognized a specific
signal with a molecular mass of
40 kDa in RL and HT lymphomas.
This band corresponds to the estimated molecular mass of the
GHRH receptor isoform encoded by SV1. RT-PCR and ligand binding
studies also revealed the expression of SV1 and the presence
of high-affinity binding sites for GHRH on RL and HT tumors.
Because the antiserum developed recognizes the tumoral GHRH
receptor protein encoded by SV1, it should be of value in various
investigations.
splice variant  growth hormone-releasing hormone receptor  polyclonal
antibody  non-Hodgkin’s lymphoma
Antagonists of growth hormone-releasing hormone (GHRH)
inhibit the growth of experimental human cancer cell lines
xenografted into nude mice or cultured in vitro and are being
developed for cancer therapy (1–4). To design still more potent
antagonists, we have to fully understand their mechanism of
action. GHRH antagonists suppress tumor growth through
indirect and direct pathways. The indirect mechanism operates
through a suppression of the growth hormone release from the
pituitary and the resulting inhibition of the production of
insulin-like growth factor I in the liver (1–11). However, the
principal action of GHRH antagonists is probably exerted
directly on tumors and appears to be mediated by specific
receptors for GHRH antagonists on cancer cells (1–9, 11–13).
Although the mRNA for GHRH and immunologically active
GHRH were demonstrated in various human tumor cells, the
mRNAfor human pituitaryGHRHreceptor (GHRH-R) has not
been detected on these tumor cells or any of the other cancer
models (11, 14, 15).
Because of the structural similarities between GHRH and
vasoactive intestinal peptide (VIP), the receptors for VIP could
be a target for the GHRH antagonists, but GHRH antagonists
inhibit the proliferation of MiaPaCa-2 human pancreatic tumor
cells, which do not express the receptors for VIP (13). Moreover,
in LNCaP human prostatic carcinoma cells, which are positive
for the VIP receptors, GHRH antagonists inhibit tumor growth
more powerfully than the antagonists of VIP (13).
These and other findings (1–15) suggested the involvement of
specific receptors for GHRH antagonists on human cancers. We
then reported the expression of four splice variants (SVs) of the
full-length human GHRH-R in normal tissues and certain cancer
cell lines on the basis of sequence analyses of cDNA encoding
these receptors (16, 17). The deduced amino acid sequence of
one of these SVs, called SV1, shows a close similarity to that of
the full-length GHRH. However, the first 89 aa in the extracellular
domain at the N terminus of the pituitary GHRH receptor
are replaced in SV1 by a different, 25-aa polypeptide chain (16).
Other studies show that, although the N-terminal extracellular
domain plays an important role in the interaction between
GHRH and the pituitary GHRH-R, the replacement of this
domain with the N terminus of the receptor for VIP or secretin
does not lead to the complete loss of function of the receptor
(18). Unlike the other three SVs, the SV1 has all seven transmembrane
domains and the whole third intracellular loop, the
latter being critical for the interaction with G proteins (16,
19–21).
On the basis of these structural characteristics, the SV1 might
be able to respond to GHRH and its antagonistic analogs and
activate the signal transduction system of the tumor cells. The
expression of the mRNA for SV1 has been detected, along with
high-affinity binding sites for the radiolabeled GHRH antagonist
JV-1-42, on a wide variety of human cancers, including
gastroenteropancreatic, renal, lung, and prostatic tumor cell
lines and surgical specimens of human prostate cancer (22–25).
A comparison of the binding characteristics of GHRH, VIP,
pituitary adenylate cyclase-activating polypeptide, and GHRH
antagonists revealed that GHRH antagonists bind more powerfully
to the membrane fraction of CAKI-I human renal cell
adenocarcinoma than to the other peptides (17). High affinity of
the antagonists to the tumoral receptor facilitates their selective
uptake from the circulation onto the tumor tissue (17, 24). In
addition, GHRH increased the proliferation of NIH 3T3 mouse
fibroblasts transfected with the plasmid expressing the mRNA
for SV1, and this effect was inhibited by the GHRH antagonist
JV-1-38 in a dose-***endent manner (26).
Abbreviations: GHRH, growth hormone-releasing hormone; GHRH-R, GHRH receptor; SV,
splice variant; VIP, vasoactive intestinal peptide; KLH, keyhole limpet hemocyanin.
‡G.L.T. and J.E.H. contributed equally to this work.
§On leave of absence from: ***artment of Anatomy, University of Pe´ cs Medical School,
H-7643 Pe´ cs, Hungary.
¶To whom correspondence should be addressed at: Veterans Affairs Medical Center, 1601
Perdido Street, New Orleans, LA 70112-1262. E-mail: [email protected].

On leave of absence from: ***artment of Medical Chemistry, Albert Szent-Gyo¨ rgyi Medical
Center, University of Szeged, H-6720 Szeged, Hungary.
© 2004 by The National Academy of Sciences of the USA
15160–15165  PNAS  October 19, 2004  vol. 101  no. 42 www.pnas.orgcgidoi10.1073pnas.0406348101

[ItalianMuscle]

Ok i understand little what that means but not all..

That talks about canceress cells of tumor but mine is non
all just small little dot like a small hard peeple of fluid..

Has there ever been study on were gh makes tumors grow ?

Now they say gear can cause tumors and mine never grew Why is that Luc i doubt that for 8yrs .. Any studies .. explain why

[ItalianMuscle]

I was reading something yesterday i should of copy past it.
It was on HGH and effect on excisting ne-growing benign tumor
and said that they test in in mice and HGH
didn't accelerate the growth of tumor.

Let me see if i can find it

[ItalianMuscle]

I been doing alot of research on net and found no evidence that
HGH can activate or accelerate a Non active benign tumor growth..

[IBdmfkr]

I'd go ahead and take it and then report back your results in 6months..

If you have a huge tumor I'm sorry, we're just trying to look out for your health and the fact that GH gives VERY minimal results for the cost and risks.

[ItalianMuscle]

bro no huge tumor,
A benign tumor is like a hard ball of fluid.. Thats all (simply)
There are diff types of tumors..

I'm talking about a benign tumor that is smaller than a dime
Non-active state for 12 Yrs now and i bee on every type
of steroid possible (almost) stacking and what not for 7yrs now.

Always monitor it every yr MRI and not growing.

explain why ???? and please don't be wise and say luck

[Random]

^^^it doest matter how many different steroids you have been on for however many years (to my knowledge that is) gear will not make a tumor grow, GH and all other peptides will and could, why keep posting for someone to say what u want to hear, hell, people smoke cigarettes every day year after year after the surgeon general tells them not to, tells them it causes side effects including lung cancer....so if youre goin to use it, Use it then, why bother us to admit what u want to hear, after all i think its safe to assume many of us are not doctors, why dont u ask a doc..

CD

[IBdmfkr]

I just suggested you do it and report back, be our guinea pig please.

Let us know how it turns out.

[Titleist]

Bro, you have had many Vets chime in on this one with their opinion and what they would do. I know it isn't what you want to hear, but I agree as well. It is too risky for my blood.

Consult with your doctor and see what he thinks. Get him to give you his professional opinion on the matter, then go from there.

[TheNextBigThing]

Gear has nothing to do with formation or growth of tumors so that is a moot point. One of the main causes of tumor growth is IGF (i.e. if you have a tumor already it will grow, I haven't read anything that says it will make you grow one). There is alot of liturature out there on this subject and I suggest you read it. If you do try this anyway, I hope that you keep a log because this would disprove alot of what is believed about the formation and growth of tumors.

[ItalianMuscle]

Guys I really do appreciate all the replie's that i got from this post.
I mean there is alot of say not do it and say i don't wanna hear it , I just wanted proof , Facts , articles on does HGH make a non-active Tumor grow (benign tumor) , My neuorlogist awhile back said it is like a dead cell sitting there.

I think i will ask my primary care doc, what u think
if i do it is confidential correct

Thanks guys

[IBdmfkr]

I'd ask a specialist.. asking a primary care doctor this question would be out of his league IMO.

[ItalianMuscle]

Ok i will ask my neuoroligist .. I have one og the besat
at the Mass Gen Hospital for last 15yrs, see what he say

I wonder if annyone can find any studies of HGH and benign tumors.

[crazyhorse666]

I had a gaint tumor removed about 5 years ago it was the worst time of my life. I went in to the doctor the best shape of my life 186lbs 6% shreaded. came out 2 weeks later 146lbs I could hardly keep my head up.I couldnt lift a gallon of milk for 2 months. I wouldnt wish that on my worst enemy. Im going to do some hgh but i have no tumor's left in me. I now you will do what you want just be ready to acept what happens to you weather it is good or bad.

[perfectbeast2001]

I cannot believe you are considering this. GH gives such minimal results it just is not worth it, even if you were an IFBB pro it wouldn't be worth it (and you aren't). You will get all kinds of opinions if you dig deep enough on this subject. That is because no one really knows for sure. Unfortunately there are not many studies done on Bodybuilders and drug use. Although you can probably find a few studies using rats,aids victims and petri dishes. Are you willing to risk your life becase a petri dish study suggested that GH wont grow benign tumours.
The point is that in theory IT COULD. Dont be ignorant. Stick with AS and thank god you are healthy and fit enough to enjoy using AS and training with weights.

[THE JU-ICE]

Do it!!!! Prove everyone who has ever studied this drug wrong. You should do twice as much just to emphasis your point. GH is called growth hormone for a reason, it makes shit grow.

[ss01]

wow so may negative opinions..

Come on we are all hook on gear and want be bigger and be competitive in the gym , I have not read anywhere that GH will make tumor grow remember it is not canceres and all a benign tumor is a small hard ball of fluid.

Has anyone have any real hard evidence that GH will make it grow ?

We wall play russian roullete with gear and GH, slin and so on and we now it ain't good for our bodies..

I been doing alot of research on net and found no evidence that
HGH can activate or accelerate a Non active benign tumor growth..

That's because THERE IS ABSOLUTELY NO EVIDENCE that GH grows benign tumors. If you have a full-blown cancer, then GH will help it grow somewhat, not that it will make MUCH of a difference anyway, in this worst-case scenario which is not yours..

Listen. Your body makes GH already. What is the #1 hormone released by your body as you exercise, responsible for casically ALL the HEALTH-ENHANCING EFFECTS OF EXERCISE, INCLUDING LOWERED CANCER RATE? GH.

I would not hesitate for one second bro, since all that natural GH you have been making did absolutely nothing to that "tumor".

[perfectbeast2001]

I hope that last post was a joke.....

[Titleist]

I hope that last post was a joke.....

It wasn't. This is coming from the same guy whose take on IGF was backed by no studies whatsoever.

[fred9]

it's quite well known that igf can accelerate the growth of cancer cells...there are some ways to take large doses of hgh without this risk by blokcing the igf-receptors...u have then still the fatburning properties of hgh(which is dose ***endent)

but also AS increases igf output and especially when also nolvadex is administrated...nolvadex upregulates the igf-receptors...

for studies google: igf+cancer

[ss01]

I hope that last post was a joke.....

Perhaps if you studied real science instead of broscience you would know without the shadow of a doubt whether or not it is a joke.

But then again, you would not have 6,000 posts on this board... You would hang out at a place where people know stuff.