I am in my late 30's. I having been checking out various HRT clinics online. The one thing that stands out is they seem to be pricy. I can get 3 10 ml vials from my guy for what 1 cost at a hrt clinic. So I was thinking about staying steady on my bloodwork, seeing my doctor for regular check ups and getting a good supply of E and staying on 250 mg a week dosage. Self administration may not be a bad choice other than the HRT clinics your paying for the legailty of it. Does anyone go that route? If you do how does it work for you?