Struggling to get pct gear in australia need alternatives

[The WeaPoN]

i have all the test p i need for my upcoming cycle, but i having the same dramas as last time i did my cycle trying to get some ai's is a real bit$h her in oz, even went to the dr's and did the soap story but they wouldnt give me anything that is give to women, so i need some ideas for alteratives?

got tribulus but that does shit

[yarakefendi]

dude im the opposite
i can get all ai's serms etc but cant get a hold of good gear to well

[The WeaPoN]

serious, i have no probs with getting gear at all just ai's at the moment, you from australia?

[chew78]

I am from Aus and have ordered pct gear from the site above havnt received it yet but hopefuly will arrive fingers crossed, but would love to know where to get some here as well??????

[The WeaPoN]

can you let us no how you go with your package mate if that alright

[chew78]

sure will fingers crossed thats for sure, but would be awsome if we could find some Locally surely we could get it somewhere or does no one in oz do pct??

[Dagron]

Hey bro what I would suggest is that you check out Primordial Performance's product called Dermacrine Sustain. It has been used by a great many on another popular steroid orientated BB forum both as a part of PCT and even as a standalone for PCT to rave reviews. I am most likely not allowed to link you to such logs but it won't take more than a google to find some positive feedback. Their site is www.primordialperformance.com but their products can now be purchased through Nutraplanet as well. I will try to find the official write up for you with the science behind it.

The important thing for you here is that it works and it has nothing that Australian customs would confiscate in within it.

[Dagron]

Dermacrine Sustain is a topically applied product that can reduce estrogen and increase testosterone. Dermacrine Sustain is designed as a hormonal optimizer for long-term use. By safely and effectively reducing and blocking estrogens, Dermacrine Sustain can help increase the primary male androgen – Testosterone. This may help increase energy, lean muscle, libido, and sexual performance.

As a benefit to men using other “testosterone” products, Dermacrine Sustain serves as our most powerful product for encouraging the bodies own production of testosterone and ************ of hormone production.


* Dermacrine Sustain is positively correlated to improve body composition, increase virility, and improve erectile function by antagonizing estrogens and stimulating the body's natural production of testosterone.
* Dermacrine Sustain utilizes a higher dose of the proprietary Phyto Aromatase Inhibitor (Phyto AI) complex and does not include the hormone precursors DHEA and pregnenolone.
* Skin is the optimum site for delivery of the polyphenols and flavonoids contained in Dermacrine Sustain.
* The hormone profile has tremendous influence over body composition, mental performance, the immune system, cholesterol levels, prostate health and sexual performance. Genetics, lifestyle, and age can all influence your steroid enzymes and hormone profile for better or worse.
* For maximum results, use Dermacrine Sustain everyday for at least 4 weeks. Dermacrine Sustain can be cycled back-to-back with original Dermacrine for an extra “boost” in hormone levels, however Derma Sustain is an excellent product for long-term use and safely keeping an optimized hormone profile.

Dermacrine Sustain is positively correlated to improve body composition, increase virility, and improve erectile function by antagonizing estrogens and stimulating the body's natural production of testosterone.

HORMONAL OPTIMIZATION
muscle growth - fat loss

Dermacrine Sustain utilizes a higher dose of the proprietary Phyto Aromatase Inhibitor (Phyto AI) complex and does not include the hormone precursors DHEA and pregnenolone. This makes Dermacrine Sustain suitable to cycle with our original Dermacrine, or to be used as a longer-term testosterone support formula. Dermacrine sustain will also induce a more powerful LH & FSH release, therefore providing more powerful stimulation of the bodies own testosterone production from the testis.

The Phyto-AI blend consists of resveratrol, 7,8 benzoflavone and chrysin, which are natural polyphenols that have been proven to be effective anti-estrogens.1,2,23 The action by which our Phyto-AI complex inhibits estrogen, is by binding to the aromatase enzyme (CYP 17) and preventing testosterone and androstenedione from interacting with aromatase and converting to estradiol and estrone.3 Another mechanism in which estrogen is reduced, is resveratrol's ability to decrease production of the actual aromatase enzyme itself 4.

This unique combination effectively and safely limits estrogen production. Thus, estrogen is kept in control to avoid nipple sensitivity, fat depositing and testicular shrinkage. Research with animals show that the ingredients in the Phyto-AI blend help enhance fertility, by eliciting a positive response on the hypothalamus, pituitary, testicular axis (HPTA).5,6 Meaning, the Phyto-AI blend increases lutienizing hormone (LH) and follicle stimulating hormone (FSH) release from the pituitary. As most of you know, these are the hormones sent from the brain that trigger testosterone production and spermatogenesis from the testis. Remember, FSH also sensitizes the testis to the effects of LH by increasing the number of LH receptors in the testis, therefore enhancing testicular sensitivity and increasing the testosterone response.

In the animal study with resveratrol, the LH & FSH levels doubled , while testosterone nearly tripled compared to the control animals.5 Animal studies with chrysin and benzoflavone also noted increased sperm production, increased mounting behavior and a general “aphrodisiac” like property from these flavones. This applies to humans as well, since chrysin and 7,8 benzoflavone are the main active constituents of passion flower (pass***ora incarnate) which has long been known to posses aphrodisiac like properties and has been prescribed to humans for sexual disorders in other countries.7,8

An interesting effect seen with resveratrol is its ability to antagonize estrogen at the estrogen receptor (ER) by acting as a selective estrogen receptor modulator (SERM) 5,12,13 This partly explains the effects resveratrol has on LH & FSH release. The action can be explained by comparing resveratrol to other SERM's such as clomid & nolvadex. Fortunately, it appears resveratrol's benefit is not associated with the toxic side effects of clomid and nolvadex such as liver stress, DNA damage, reduced sex drive, and reduced fertility. 5,12-22

Aside from simply reducing and antagonizing estrogen, resveratrol has been under intense research for its chemo-preventative effects in breast and prostate cancer.24-27 It also appears that resveratrol has potential for the treatment of metabolic syndrome, by increasing mitochondrial function and insulin sensitivity. 28 In a recent animal study, high doses of resveratrol were able to increase mitochondrial energy expenditure in fat tissue, while increasing mitochondrial concentration in muscle tissue. That's right, resveratrol was able to chemically remodel muscle tissue for increased physical output, without exercise. It was well summarized here by M Lagouge et al. -

“resveratrol could hence be viewed as a performance enhancing drug, which, in contrast to other pharmacological mediators, such as anabolic steroids, improves performance by changing myo-fiber specificity rather than increasing muscle mass”

These are exciting implications for the ingredients in Dermacrine Sustain. We've included high a concentration of these actives to resemble the dosages used in the virility enhancing clinical studies mentioned above. As a side benefit to the estrogen reducing, testosterone boosting effects, the natural ingredients in Phyto AI have shown to be “vaso-relaxants”, which may help promote blood flow to genitalia and support erectile function, while also supporting healthy cardiovascular system.9-11

SIDE EFFECTS
catuionary advice

The ingredients in Dermacrine Sustain are known to be safe, however this product is not intended to be used by anyone under the age of 18, females whom are pregnant or breast feeding, elderly, or anyone diagnosed with a serious health condition including but not limited to cancer, BPH, epilepsy, depression, diabetes, cardiovascular disease or high blood pressure. Always consult your physician before using Dermacrine Sustain with any over-the-counter or prescription medication. Discontinue use if you experience headache, nausea, heart palpitations or skin rash.

Some users may experience acne and an increased appetite, related to increased androgen and testosterone levels. Reducing dosage may alleviate these symptoms. For those wishing to avoid an increase in appetite we also suggest stacking Dermacrine with a dietary supplement designed to suppress appetite.

Dermacrine's topical formula contains ingredients that temporarily increase photosensitivity (3-4hr) and increase chance of sunburn. Therefore, caution is advised for those applying the product immediately before direct sun exposure. Also, be sure to wash hands after application and AVOID product contact with eye's, mouth and genitals.

REFERENCES

1. Inhibition of human estrogen synthetase (aromatase) by flavones JT Kellis, Jr and LE Vickery Science, Sep 1984; 225: 1032 - 1034.

2. The Red Wine Polyphenol Resveratrol Displays Bilevel Inhibition on Aromatase in Breast Cancer Cells Yun Wang, Kai Woo Lee, Franky L. Chan, Shiuan Chen, and Lai K. Leung Toxicol. Sci., Jul 2006; 92: 71 - 77.

3. The effects of dietary phytoestrogens on aromatase activity in human endometrial stromal cells. KM Edmunds, AC Holloway, DJ Crankshaw, SK Agarwal, and WG Foster Reprod Nutr Dev, November 1, 2005; 45(6): 709-20.

4. Phytoestrogens and their low dose combinations inhibit mRNA expression and activity of aromatase in human granulosa-luteal cells. S Rice, HD Mason, and SA Whitehead J Steroid Biochem Mol Biol, Nov 2006; 101(4-5): 216-25

5. trans-Resveratrol, a Natural Antioxidant from Grapes, Increases Sperm Output in Healthy Rats M. Emília Juan, Eulalia González-Pons, Thais Munuera, Joan Ballester, Joan E. Rodríguez-Gil, and Joana M. Planas J. Nutr., Apr 2005; 135: 757 – 760

6. Prevention of chronic alcohol and nicotine-induced azospermia, sterility and decreased libido, by a novel tri-substituted benzoflavone moiety from Pass***ora incarnata Linneaus in healthy male rats. K Dhawan and A Sharma Life Sci, Nov 2002; 71(26): 3059-69.

7. Lutomski J: Die Bedeutung der Passionsblume in der Heilkunde. Pharmazie in unserer Zeit 1981;10:45–49.

8. Tyler VE: The Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. Pharmaceutical Products Press, New York , 1993.

9. Effects of the dietary flavonoid chrysin in isolated rat mesenteric vascular bed. IC Villar, M Galisteo, R Vera, F O'Valle, MF Garcia-Saura, A Zarzuelo, and J Duarte
J Vasc Res, Nov 2004; 41(6): 509-16.

10. Vasorelaxant and antioxidant activity of flavonols and flavones: structure-activity relationships. OL Woodman, WF Meeker, and M Boujaoude J Cardiovasc Pharmacol, Sep 2005; 46(3): 302-9.

11. Vasorelaxant effects of grape polyphenols in rat isolated aorta. Possible involvement of a purinergic pathway. Mendes A, Desgranges C, Cheze C, Vercauteren J, and Freslon JL. Fundam Clin Pharmacol 17: 673–681, 2003

12. Is resveratrol an estrogen agonist in growing rats? Turner, R. T., Evans, G. L., Zhang, M., Maran, A. & Sibonga J. D. Endocrinology 140: 50–54. (1999)

13. Low dose effects of bisphenol A on sexual differentiation of the brain and behavior in rats.

Kubo, K., Arai, O., Omura, M., Watanabe, R., Ogata, R. & Aou, S. Neurosci. Res. 45: 345–356. (2003)

14. Epigenetic reprogramming of liver cells in tamoxifen-induced rat hepatocarcinogenesis. VP Tryndyak, O Kovalchuk, L Muskhelishvili, B Montgomery, R Rodriguez-Juarez, S Melnyk, SA Ross, FA Beland, and IP Pogribny Mol Carcinog, Mar 2007; 46(3): 187-97

15. Biotransformation of the Antiestrogen Clomiphene to Chemically Reactive Metabolites in the Immature Female Rat Peter C. Ruenitz, Richard F. Arrendale, Garry D. George, Carolyn B. Thompson, Corwin M. Mokler, and Nitin T. Nanavati Cancer Res., Aug 1987; 47: 4015 - 4019.

16. Antiestrogens and the formation of DNA damage in rats: a comparison. Kim SY, Suzuki N, Laxmi YR, Umemoto A, Matsuda T, Shibutani S. Chem Res Toxicol. 2006 Jun;19(6):852-8.

17. Activation of 4-hydroxytamoxifen and the tamoxifen derivative metabolite E by uterine peroxidase to form DNA adducts: Comparison with DNA adducts formed in the uterus of Sprague-Dawley rats treated with tamoxifen Deena N. Pathak, Krisztina Pongracz, and William J. Bodell Carcinogenesis, Sep 1996; 17: 1785 - 1790

18. Activation of the Tamoxifen Derivative Metabolite E to Form DNA Adducts: Comparison with the Adducts Formed by Microsomal Activation of Tamoxifen Krisztina Pongracz, Deena N. Pathak, Takemichi Nakamura, Alma L. Burlingame, and William J. Bodell Cancer Res., Jul 1995; 55: 3012 - 3015.

19. Teratogenic effects of clomiphene, tamoxifen, and diethylstilbestrol on the developing human female genital tract. GR Cunha, O Taguchi, R Namikawa, Y Nishizuka, and SJ Robboy Hum Pathol, Nov 1987; 18(11): 1132-43.

20. Effects of tamoxifen on the fertility of male rats MK Gill-Sharma, K Gopalkrishnan, N Balasinor, P Parte, S Jayaraman, and HS Juneja J Reprod Fertil, Nov 1993; 99: 395.

21. Effect of chronic administration of Tamoxifen on fertility in male bonnet monkeys (Macaca radiata). AJ Rao, SG Ramachandra, V Ramesh, HN Krishnamurthy, S Jayaraman, K Gopalakrishnan, and HS Juneja Andrologia, May 1998; 30(3): 129-32.

22. Tamoxifen treatment and its consequences Adrian Shulman, Ilan Cohen, Ron Maymon, and Marco M. Altaras Hum. Reprod., Aug 1995; 10: 2174 - 2175

23. The Red Wine Polyphenol Resveratrol Displays Bilevel Inhibition on Aromatase in Breast Cancer Cells Y. Wang, K. W. Lee, F. L. Chan, S. Chen, and L. K. Leung Toxicol. Sci., July 1, 2006; 92(1): 71 - 77.

24. Phytoestrogen regulation of a Vitamin D3 receptor promoter and 1,25-dihydroxyvitamin D3 actions in human breast cancer cells. J Steroid Biochem Mol Biol. 2003 Feb;84(2-3):149-57

25. Potent Inhibitory Effects of Resveratrol Derivatives on Progression of Prostate Cancer Cells. Yoo KM, et al. Arch Pharm (Weinheim) Apr 18;339(5):238-241 (2006)

26. Resveratrol and propolis as necrosis or apoptosis inducers in human prostate carcinoma cells. Scifo C, et al. Oncol Res. 2004;14 (9) :415-26.

27. Detoxifying Cancer Causing Agents to Prevent Cancer Margaret Hanausek, Zbigniew Walaszek, and Thomas J. Slaga Integr Cancer Ther, Jun 2003; 2: 139 - 144.

28. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. M Lagouge, C Argmann, Z Gerhart-Hines, H Meziane, C Lerin, F Daussin, N Messadeq, J Milne, P Lambert, P Elliott, B Geny, M Laakso, P Puigserver, and J Auwerx Cell, Dec 2006; 127 (6) : 1109-22


We use a highly purified extract of 7,8 benzoflavone (alpha-naphthoflavone), which is a flavanoid isolated from the flower Pass***ora incarnata. The 7,8 Benzoflavone moiety is believed to be the compound responsible for the aphrodisiac properties of the plant.1,2 7,8 benzoflavone is a powerful aromatase inhibitor which competes with androstenedione and testosterone for the aromatase enzyme, thus limiting estrogen production.5 Animal experiments have confirmed 7,8 benzoflavone to be a potent promoter of fertility by inhibiting estrogen, increasing testosterone and dramatically increasing sperm concentration and mounting behavior.3,4 Besides inhibiting estrogen production, 7,8 benzoflavone can favorable influence estrogen metabolism by reducing 4-hydroylation and toxic quinine production.9-10

We use a highly purified extract of Chrysin, which is a flavonoid extracted from Pass***ora incarnate. Chrysin was a popular “estrogen reducing” oral supplement in the 90's, however chrysin was found to be poorly absorbed orally, so it lacked real world results.11,12 Fortunately, chyrsin has a low molecular weight making it ideal for penetration through the skin. Indeed, once chrysin reaches the blood stream it becomes a very potent anti-estrogen that binds well to human aromatase tissue.13-15 Similar to 7,8 benzoflavone, chrysin has been used in animals to stimulate spermatogenesis and reproduction, presumably by reducing estrogen and increasing testosterone.3

We use a highly purified extract of Resveratrol extracted from Polygonum cuspidatum Sieb, otherwise known as grape skin. Resveratrol is another plant compound with poor oral bioavailability,16 but ideal for topical delivery due to its small molecular size. Similar to chrysin and benzoflavone, resveratrol has the ability to inhibit estrogen, boost testosterone while also raising luteinizing and follicle stimulating hormone (LH & FSH) Animal studies have shown resveratrol to double LH and FSH while tripling testosterone levels.17,18 Aside from supporting virility, resveratrol has been shown to have powerful in-vitro cancer fighting properties while being non-toxic even at extremely high doses.19-22

REFERENCES

1. Lutomski J: Die Bedeutung der Passionsblume in der Heilkunde. Pharmazie in unserer Zeit 1981;10:45–49.

2. Tyler VE: The Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. Pharmaceutical Products Press, New York, 1993.

3. Drug/substance reversal effects of a novel trisubstituted benzoflavone moiety (BZF) isolated from Pass***ora incarnata Linn.—a brief perspective KAMALDEEP DHAWAN Addiction Biology (December 2003) 8, 379 – 386

4. Prevention of chronic alcohol and nicotine-induced azospermia, sterility and decreased libido, by a novel tri-substituted benzoflavone moiety from Pass***ora incarnata Linneaus in healthy male rats. K Dhawan and A Sharma Life Sci, Nov 2002; 71(26): 3059-69.

5. Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study. Kao YC, Zhou C, Sherman M, Laughton CA, Chen S Environ Health Perspect 1998;106:85–92

6. Regioselective 2-hydroxylation of 17beta-estradiol by rat cytochrome P4501B1. M Rahman, C Hayes Sutter, GL Emmert, and TR Sutter Toxicol Appl Pharmacol, November 1, 2006; 216(3): 469-78

7. Naturally occurring coumarins inhibit 7,12-dimethylbenz[a]anthracene DNA adduct formation in mouse mammary gland. Misty Prince, Cheryl T. Campbell, Taylor A. Robertson, Amy J. Wells, and Heather E. Kleiner Carcinogenesis, Jun 2006; 27: 1204 - 1213.

8. DNA adduct formation in liver and kidney of male Syrian hamsters treated with estrogen and/or Your browser may not support display of this image.-naphthoflavone. Liehr JG, Gladek A, Macatee T, Randerath E, Randerath K 1991 Carcinogenesis 12:385–389

9. Modulation of rabbit and human hepatic cytochrome P-450-catalyzed steroid hydroxylations by alpha-naphthoflavone GE Schwab, JL Raucy and EF Johnson Volume 33, Issue 5, pp. 493-499, 05/01/1988

10. Metabolic oxidation of diethylstilbestrol to diethylstilbestrol-4',4'' -quinone in Syrian hamsters. Roy D and Liehr JG Carcinogenesis 10: 1241-1245 (1989)

11. Endocrine and Lipid Responses to Chronic Androstenediol-Herbal Supplementation in 30 to 58 Year Old Men Gregory A. Brown, Matthew D. Vukovich, Emily R. Martini, Marian L. Kohut, Warren D. Franke, David A. Jackson, and Douglas S. King J. Am. Coll. Nutr., Oct 2001; 20: 520

12. Disposition and metabolism of the flavonoid chrysin in normal volunteers. Walle T, Otake Y, Brubaker JA, Walle UK, Halushka PV. Br J Clin Pharmacol. 2001 Feb;51(2):143-6.

13. The effects of dietary phytoestrogens on aromatase activity in human endometrial stromal cells. KM Edmunds, AC Holloway, DJ Crankshaw, SK Agarwal, and WG Foster Reprod Nutr Dev, November 1, 2005; 45(6): 709-20.

14. Phytoestrogens and their low dose combinations inhibit mRNA expression and activity of aromatase in human granulosa-luteal cells. S Rice, HD Mason, and SA Whitehead J Steroid Biochem Mol Biol, Nov 2006; 101(4-5): 216-25.

15. Inhibition of human estrogen synthetase (aromatase) by flavones JT Kellis, Jr and LE Vickery Science, Sep 1984; 225: 1032 - 1034.

16. Methylated Flavonoids Have Greatly Improved Intestinal Absorption and Metabolic Stability Xia Wen and Thomas Walle. Drug Metab. Dispos., Oct 2006; 34: 1786 - 1792.

17. The Red Wine Polyphenol Resveratrol Displays Bilevel Inhibition on Aromatase in Breast Cancer Cells Yun Wang, Kai Woo Lee, Franky L. Chan, Shiuan Chen, and Lai K. Leung Toxicol. Sci., Jul 2006; 92: 71 - 77.

18. trans-Resveratrol, a Natural Antioxidant from Grapes, Increases Sperm Output in Healthy Rats M. Emília Juan, Eulalia González-Pons, Thais Munuera, Joan Ballester, Joan E. Rodríguez-Gil, and Joana M. Planas J. Nutr., Apr 2005; 135: 757 – 760

19. Phytoestrogen regulation of a Vitamin D3 receptor promoter and 1,25-dihydroxyvitamin D3 actions in human breast cancer cells. J Steroid Biochem Mol Biol. 2003 Feb;84(2-3):149-57

20. Potent Inhibitory Effects of Resveratrol Derivatives on Progression of Prostate Cancer Cells. Yoo KM, et al. Arch Pharm (Weinheim) Apr 18;339(5):238-241 (2006)

21. Resveratrol and propolis as necrosis or apoptosis inducers in human prostate carcinoma cells. Scifo C, et al. Oncol Res. 2004;14(9):415-26.

22. Detoxifying Cancer Causing Agents to Prevent Cancer Margaret Hanausek, Zbigniew Walaszek, and Thomas J. Slaga Integr Cancer Ther, Jun 2003; 2: 139 - 144.