Letro inhibiting 98% of estrogen ?

[JasonR]

One study states that: (All from ****-RX steroid profiles, by AR)
"Letrozole is currently the most powerful aromatase inhibitor available. In women with breast cancer, it has been shown to reduce estrogen levels by 98% or more"

Then they say:
and in another clinical study done on both young and elderly men, intravenous administration of Letrozole lowered Estrogen by 46% in the young men tested, and 62% in the elderly subjects.


and then:
in one study done on men, to reduce estrogen levels by roughly a third. (4)


so... is it 98% only in women ?

[pr0digy9daniel]

Yeh, this is interesting. I have also read conflicting reports. Is letro really as powerful as they claim in men?

[Kratos]

I went skiing on letro, and every joint in my body hurt after and I ski a lot
elbows, shoulders, knees, ankels, spine, wrists
Low estrogen for sure

[JasonR]

No doubt about it.
pulled my quad sprinting today even after doing a 30 minute wwarmup ! micro tears all over the place with no estro to fix them.

my chest feels like shit too after benching, its just not recovering !!! its been 2 days and i can barely move my arms !


BUT, im lookin bigger cuz of the test boost

[Kratos]

Letrozole (CGS 20267), a new oral aromatase inhibitor for the treatment of advanced breast cancer in postmenopausal patients.Trunet PF, Bhatnagar AS, Chaudri HA, Hornberger U.
Department of Research, Pharmaceuticals Division, Ciba-Geigy Limited, Basel, Switzerland.

Letrozole is a new orally, active, potent, and highly specific non-steroidal aromatase inhibitor. Letrozole is about 200 and 10000 times as potent as aminoglutethimide (AG) in vitro and in vivo, respectively. Letrozole was tested in healthy men and postmenopausal women and in postmenopausal patients with advanced breast cancer (ABC). Levels of circulating estrogens decreased by more than 75 to 95% from pre-treatment levels have been observed in patients treated with daily doses of 0.1 to 5 mg letrozole. No clinically relevant changes in other hormones of the endocrine system were found. In four phase Ib/IIa trials, letrozole has shown anti-tumor activity in postmenopausal patients with ABC previously treated with hormonotherapy and/or chemotherapy. Letrozole was well tolerated. Phase IIb/III studies are on going to compare two doses of letrozole with megestrol acetate or AG in order to confirm the anti-tumor efficacy of letrozole in the treatment of ABC in postmenopausal patients who progressed/relapsed following treatment with anti-estrogens.

PMID: 9142959 [PubMed - indexed for MEDLINE]

IDK, says they tested it in men
Not a lot of consistant info on the efficency of AI's in men though.

[JasonR]

5mg of letro.. i heard they go that high in medicine.. any additional anti E effect over the standard 2.5mg ED ? or is there a maximum inhibition dose wit that drug.

[Kratos]

well, it says in the package insert not to go over 2.5mg ed in men because they won't be able to get wood. I'm guessing there is more anti-e effect comming at the higher dose which is why men can't get wood over 2.5mg. I like using letro at .5mg ed on cycle, more than enough for me.

[JasonR]

just took 5mg, downloading sum porn to test that claim.

[Kratos]

Not sure you want to go that high, I guess I just don't see the point. What is the point? You got some tig ol biddies?

I would be very worried about estrogen reboud at such a high dose, the taper off is going to need to be a long one. Mabe follow your letro with Aromasin to kill off the enzyme and eliminate the rebound.

I am done running experiments that may or may not make my dick not work. I decided my dick needs to work. Tren only turned my penis into noting but a pee tube.

[JasonR]

lol... just for 1 day... ill get back to 2mg 2m!

btw i am running nolva 40mg WITH IT. trying to shrink puffy nipples that nolva left me with... working great so far. amazing stuff that letro.

[Kratos]

Open dose-finding study of a new potent and selective nonsteroidal aromatase inhibitor, CGS 20 267, in healthy male subjects.Trunet PF, Mueller P, Bhatnagar AS, Dickes I, Monnet G, White G.
Research and Development Department, CIBA-GEIGY Limited, Basel, Switzerland.

The aim of this open, dose-finding study was to evaluate the effects of single dose CGS 20 267, a new oral nonsteroidal aromatase inhibitor, on the inhibition of estrogen production and also on the production of adrenal and testicular steroids in healthy male subjects. Nine dose levels ranging from 0.02-30 mg and placebo were tested, each dose being given to 3 subjects only. A total of 18 subjects were included; 12 of them received 2 single administration, the remaining 6 were exposed only once to one of the 2 highest dose levels. A reduction in serum estrogen levels when compared to baseline was already observed after 2 h, reaching maximum suppression between 10 and 48 h after administration. After 24 h, a suppression of estrone levels by 60-85% from baseline was achieved with all tested doses. A reduction in estradiol levels by about 30% from baseline was observed at the lowest dose (0.02 mg). This reduction was further enhanced dose dependently to a maximum of about 90% from baseline at 24 h after administration of the highest dose (30 mg). With the higher doses (10 and 30 mg), estrogen suppression was maintained up to 3 days. A dose-dependent increase of testosterone, LH, and FSH was observed and was most pronounced in the 10- and 30-mg dose groups, which can be considered as a consequence of the long-lasting aromatase inhibition achieved with these high doses. No effect on serum cortisol and aldosterone levels was observed up to the highest dose. No clinically relevant changes were observed in blood chemistry and hematology tests. The systemic and subjective tolerability of CGS 20 267 was good at all doses. This study has shown that CGS 20 267 is a well tolerated, potent, selective, and long-acting inhibitor of the aromatase enzyme after single administration.

PMID: 8345034 [PubMed - indexed for MEDLINE]

Well if the 5mg is just a single dose this may be interesting to you. Remember Letro is long acting, so it builds up in your system over time so these doses are not for the long run. No need for the nolva imo, and it may be less productive in fact.

[Amorphic]

i would never even try 5mg of that stuff, thats insane.

2.5mg is more than enough to basically eliminate all the estrogen in your system, which is not a good thing unless you are trying to do gyno reversal.

i would never do more than .25-.5mg/ed on cycle, and i would only be using it with deca or tren

[Ashop]

One study states that: (All from ****-RX steroid profiles, by AR)
"Letrozole is currently the most powerful aromatase inhibitor available. In women with breast cancer, it has been shown to reduce estrogen levels by 98% or more"

Then they say:
and in another clinical study done on both young and elderly men, intravenous administration of Letrozole lowered Estrogen by 46% in the young men tested, and 62% in the elderly subjects.


and then:
in one study done on men, to reduce estrogen levels by roughly a third. (4)


so... is it 98% only in women ?

Ive heard and read 80-85% estrogen suppression,,,it is very effective.

[JasonR]

Cool, just one more thing regarding nolva+letro

is nolva hindering letros effectiveness or vice versa ?

[Merc..]

Cool, just one more thing regarding nolva+letro

is nolva hindering letros effectiveness or vice versa ?

Yes , studies do show nolva will reduce the blood plasma levels of type II Ai's..


Merc.

[Amorphic]

i dont know if they hinder each other (i vaguely remember that you shoudnt run them together, so yes that may be the case) but you dont need to run them together. letro eliminates estrogen and nolva binds to estrogen receptors so there is no point running nolva with letro.

the only use for nolva with letro therapy is to stave off estrogen rebound when coming off letro

[Merc..]

Interactions of antioestrogens and aromatase inhibitors.

Schmid P, Possinger K

Department of Oncology and Hematology, Charite Campus Mitte, Humboldt University Berlin, Germany.

Aromatase inhibitors and antioestrogens have shown substantial activity in primary and advanced breast cancer. Since they exhibit different modes of action, attempts have been made to combine them or to use them sequentially in order to potentially increase their efficacy. In preclinical studies, combined, sequential or alternating treatments with aromatase inhibitors and antioestrogens have failed to provide higher antitumoural activity. There are relevant pharmacokinetic interactions resulting in decreased plasma concentrations of third generation aromatase inhibitors when combined with tamoxifen. Several randomised clinical trials comparing single agent and combined treatment with tamoxifen and aminoglutethimide failed to show any benefit for the combination. Early results of the adjuvant ATAC trial indicate that single agent anastrozole is superior to tamoxifen or the combination of both. Several trials are ongoing which might help to further define the role of sequential or combined treatment with aromatase inhibitors and antioestrogens. However, to date, looking at the current evidence, combined treatment with aromatase inhibitors and antioestrogens does not appear to provide additional benefit compared to single agent treatment.




Merc.

[JasonR]

well guys, i really dont know whats going on here
been on letro for 4 dyas now, the last 2 days i took 5mg... and i'm still horny and get my boy up in a second.

On the other hand my nippe IS looking better, and i strained a muscle last sprint session.
I also get up every morning with dry mouth. real dry.

So is it fake ? any chance that letro will do nothing to your sex drive after 4 days 2 of them at mega dose ?

[vitor]

I have had BW while doing letro at 2.5mg ed. Estrogen levels decreased by roughly 65-67%. Later at 0.5 mg ed my BW showed a 45% decrease from my normal levels.

Yes 98% is only in woman.

[JasonR]

I have had BW while doing letro at 2.5mg ed. Estrogen levels decreased by roughly 65-67%. Later at 0.5 mg ed my BW showed a 45% decrease from my normal levels.

Yes 98% is only in woman.

thats some great info vitor !! thanks for sharing !

[papa pain]

i used letro at 2.5ed with nolva 20mg ed and it stopped estrogen but also stopped me gaining a thing on my course

[JasonR]

well guys, i really dont know whats going on here
been on letro for 4 dyas now, the last 2 days i took 5mg... and i'm still horny and get my boy up in a second.

On the other hand my nippe IS looking better, and i strained a muscle last sprint session.
I also get up every morning with dry mouth. real dry.

So is it fake ? any chance that letro will do nothing to your sex drive after 4 days 2 of them at mega dose ?

bump for answser

[peteroy01]

vitor-
at what point in your cycles did you get your BW done on your 2.5 and 0.5mg doses. im interested in seeing the accumulative effects of the drug.