first cycle - pct help needed

[davieboy]

first cycle will consist of

Wk 1-12 400mgs test cypionate
Wk 1-4 20mgs dianabol
Wk 1-12 0.5mg liquidex everyday from start and beyond pct (just incase)

Will I need Tamox and clomi on hand also. what would you r say i need for my pct? the liquidex everyday is because im parnoid about gyno. but better safe than sorry.

All help apreciated.

Thanks David

[Kale]

first cycle will consist of

Wk 1-12 400mgs test cypionate
Wk 1-4 20mgs dianabol
Wk 1-12 0.5mg liquidex everyday from start and beyond pct (just incase)

Will I need Tamox and clomi on hand also. what would you r say i need for my pct? the liquidex everyday is because im parnoid about gyno. but better safe than sorry.

All help apreciated.

Thanks David

Too much liquidex, you only need 0.25mg and I dont care how paranoid you are. You do know you can feel gyno coming and and can hit it with Ldex or Letro when it happens ?

PCT shpuld start 18 days after the last Test E shot and will look like this

Day 1-30- .25mg L-dex + 100mg Clomid + 20mg Nolva

[davieboy]

ok thanks for the reply. so a smalle fdosage of liquidex is needed. Will I still need to take nolva? I thought that the liquidex would replace the need for this or are you saying its better to use both.

thanks David :-)

[Kale]

ok thanks for the reply. so a smalle fdosage of liquidex is needed. Will I still need to take nolva? I thought that the liquidex would replace the need for this or are you saying its better to use both.

thanks David :-)

Yes you need to take Nolvadex in your PCT, not during your cycle. Ldex is an Aromatase Inhibitor. It works by blocking the aromatase enzyme, which is responsible for the production of estrogen where as Nolvadex is SERM (Selective Estrogen Receptor Modulator).

Read this http://forums.steroid.com/showthread.php?t=199821 and this http://forums.steroid.com/showthread.php?t=199820 . Arimidex and Ldex are the same thing

[jch3131]

Curious Kale, I read that Arimidex and Nolva do not work very well together, I guess that Arimidex makes the Nolva not as strong and thats why you should use Aromasin, or does it not really matter?

[Njord]

Curious Kale, I read that Arimidex and Nolva do not work very well together, I guess that Arimidex makes the Nolva not as strong and thats why you should use Aromasin, or does it not really matter?

It's the other way around. The Nolva will greatly decrease the blood plasma levels of the Arimidex.

[jch3131]

Ok yeah thats what it was. I'm assuming that its ok to run together tho right?

[Njord]

Ok yeah thats what it was. I'm assuming that its ok to run together tho right?

After I posted the above, I decided to find the reference regarding Nolva decreasing blood plasma levels of Anastrozole (arimidex) and Letrozole. Here is what I found:

Boeddinghaus IM, Dowsett M.
The Academic Department of Biochemistry, Royal Marsden Hospital, Fulham Road, SW3 6JJ, London, UK.
The clinical development of aromatase inhibitors (AIs) has been closely guided by clinical pharmacological investigations. During the early phases of development studies were focused on dose-related pharmacological effectiveness and specificity. More recently attention has been given to the metabolic changes which AIs elicit, with particular regard to their potential use in early breast cancer and the prophylactic setting. Pharmacological effectiveness has been studied with plasma oestrogen assays but primary oestrogens (E1 and E2) are not helpful in comparing the third generation inhibitors: anastrozole, letrozole, exemestane. All three of these compounds suppress whole body aromatisation by >96%. Most recently, we have established that significantly greater inhibition is achieved by letrozole than anastrozole at their clinically used dosages. This more complete inhibition is paralleled by significantly greater suppression of E1S.A broad panel of endocrine investigations has indicated that these compounds have essentially complete specificity at their clinical dosages. A minor androgenic effect of exemestane is revealed by a significant suppression of sex hormone binding globulin (SHBG). Lipid and bone biomarker data are being collected in many current studies. A pharmacokinetic interaction has been established between letrozole and tamoxifen, whereby reduced circulating levels of letrozole are found with combined application. Neither anastrozole nor letrozole have any effect on plasma concentrations of tamoxifen when given in combination with it.

This actually states that anastrozole and letrozole have no effect on nolva concentrations.

Anyone have any comments on this?

[davieboy]

I have just ordered the tamox/clomi/L-dex combo. this should see me fine for the pct shouldnt it? anything else you chaps think I should have on hand. Or should this cover it. thanks

[davieboy]

is it safe to say that i could run this as pct

day 1-30

.25mg tamox
.25mg liquidex
100mg clomid

would this be the right way to do it?? these three are the only things which i will have. help appreciaited

[Kale]

is it safe to say that i could run this as pct

day 1-30

.25mg tamox
.25mg liquidex
100mg clomid

would this be the right way to do it?? these three are the only things which i will have. help appreciaited

tamox should be 25mg not .25mg