Any formal studies re: HGH helping to heal injuries

[wanderingmarsupial]

Can anyone give me some links to actual medical studies, not just anecdotal personal experiences, relating to HGH helping to heal injuries?

[wanderingmarsupial]

20 views and no replys? Does anybody know if there have ever been any formal studies done?

[barondumonde]

Edit.

[fossilfuel7]

hey,

I don't know if you'll find medical studies done on "injury repair," but rather on collagen synthesis and other such factors. How do we know that IGF-1 stimulates growth of new cartilage, tendon, and ligament cells? Well, for one, that's what any medical/biology textbook will tell you. I'm sure there is a lot of reason to believe that hgh/IGF-1 will help to heal old injuries.

If you want medical studies, search for something like "growth hormone collagen synthesis" or "growth hormone tendon strength."

Here's an excerpt from one study:
http://vnet.uh.edu/vrecord_data/vpub...*GFRes2005.pdf


However, the main purpose of the current study was
to determine if adaptations in calcanean tendon collagen
occurred concomitantly with metabolic changes in body
composition after rpGH administration. The biphasic
response of tendon to rpGH administration is first noted
by DNA concentration, a marker of cell density, observed
in the rpGH treatment groups. The 2mo-rpGH
pigs had a 25% increase in the tendon DNA concentration,
while 3mo-rpGH pigs showed a 22.5% decrease
compared to control values. We hypothesize that rpGH
stimulated tendon fibroblast proliferation in 2mo-rpGH
group followed by the production of extracellular matrix
collagen by tendon fibroblasts resulting in a decreased
cellularity per dry weight of tendon in the 3mo-rpGH
group. Studies analyzing various connective tissues demonstrated
higher amounts of DNA with acute GH or
IGF treatment. Franchimont and Bassleer [18] and
Franchinmont et al. [19] used a tridimensional in vitro
model to demonstrate that incubation of human chondrocytes
with GH induced a significant increase of
DNA and proteoglycan release into the culture medium.
Similar findings were reported in animal cell cultures by
Madsen et al. [20,21]. Growth hormone stimulated
DNA synthesis in cultured chondrocytes isolated from
rat rib growth cartilage and rabbit ear. This action
was postulated to be mediated through the stimulation
of the proteoglycan core-protein synthesis. The increase
in cell density found in the present study for the 2morpGH
treatment may not be attributed to a decrease
in extracellular matrix components but rather a probable
up-regulation of mitosis. The findings of this study
suggest that there is a biphasic response of the tendon
DNA concentration to rpGH treatment. The observed
responses are consistent with GH treatment initially
stimulating mitosis followed by an up-regulation of
extracellular matrix synthesis. In this aspect, tendon
treated for three months may have fewer cells to support
a greater matrix. Furthermore, the tendon may increase
in size without a change in concentration of matrix
components.
The Achilles tendon of growing rabbits showed
decreased cellularity and ground substance with a concomitant
increase in collagen concentration, collagen crosslinks
and collagen fibril diameter [22]. Similar results
have also been reported by other research groups. In
mechanically stressed chickens, Hitchcock et al. [23] reported
tendon hypertrophy without alterations in collagen
or proteoglycan concentration. Following strenuous
exercise in chickens, Curwin et al. [10] found a significant
increase in Achilles tendon collagen deposition
without any changes in DNA, proteoglycan, collagen
concentration or tendon dry weight. The DNA concentration
was consistently unaltered in growing chickens
across all ages examined, namely 6, 8 and 12 weeks
[24]. The above findings suggest a greater matrix-collagen
turnover resulting in reduced maturation of tendon
collagen.
In the present study, considering that proteoglycan
per DNA was decreased while collagen per unit DNA
remained unchanged in tendon, there was no anabolic
effect on proteoglycan collagen metabolism in 2morpGH
pigs. Proteoglycans initially decreased in the
2mo-rpGH group followed by an increase in 3mo-rpGH
animals compared to controls. Accordingly, tendon collagen
concentration per unit cell was greater in the 3morpGH
group compared to 2mo-rpGH, while there was
no difference between 2mo-rpGH and the control group.
The increased hydroxyproline production per number of
cells after 3 months of GH treatment suggests the GH
up-regulates extracellular matrix collagen in the tendon.
These findings also suggest that there is a time delay effect
of GH on the tendon collagen accumulation, or a
‘‘lag’’ period where proliferation takes place before differentiation
occurs. We hypothesize that initially both
regulatory pathways that control collagen protein formation
and collagen degradation during the remodeling
process are in equilibrium to maintain an optimal tendon
collagen concentration. At a later stage, we suggest
that the balance in collagen turnover changes in favor of
the up-regulatory pathways resulting in an increase in
total collagen concentration as a result of GH
supplementation.

Baron..thats a good artcle I have never seen before.

Here is another study that I found quite interesting below.

Here is the link http://content.karger.com/produktedb...file=000096631


Effects of GH in Adults

Supraphysiological Doses of Growth Hormone: Effects on Muscles and Collagen in Healthy Active Young Adults
Thord Rosén

Endocrine Section, Sahlgrenska University Hospital, Göteborg, Sweden

Address of Corresponding Author

Horm Res 2006;66 (Suppl. 1):98-104 (DOI: 10.1159/000096631)

goto top of page Key Words

* Collagen
* Doping
* Growth hormone
* Muscle
* Young adult

goto top of page Abstract

Doping with growth hormone (GH) is a problem among both elite athletes and ordinary young adults who use gyms. However, the role of GH as an effective anabolic muscle doping agent, when taken alone, is questioned, although at lower doses GH may be seen to be effective when taken together with other anabolic androgenic steroids. Furthermore, GH doping does not seem to have any positive effects on cardiac performance, and fluid retention and other acr*****lic side-effects reduce its use. A positive effect of supraphysiological doses of GH does seem to be the stimulation of collagen synthesis, though, which could lower the risk of muscle and tendon rupture, allow ruptured muscles and tendons to heal faster, and allow harder training with shorter recovery periods. This may explain its ongoing use as a doping agent. Moreover, it cannot be excluded that in the future this effect on collagen synthesis could become useful in clinical practice for the treatment of muscle and tendon ruptures.

Copyright © 2006 S. Karger AG, Basel

goto top of page Author Contacts

Prof. Thord Rosén, Associate Professor
Endocrine Section, Gröna Stråket 8
Sahlgrenska University Hospital
SE-413 45 Göteborg (Sweden)
Tel. +46 31 342 7055, Fax +46 31 82 1524, E-Mail [email protected]

goto top of page Article Information

Published online: January 25, 2007
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 0, Number of References : 25

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[wanderingmarsupial]

Thanks to both of you for the info. I had done some googling for "HGH injury" and a few others but hadn't tried "collagen synthesis" or "tendon strength". Thanks.

Barondumonde could you double check your link. I can't get it to work on my end. I keep getting a "404 not found" error.

[barondumonde]

Edit.

[barondumonde]

Edit.

[fossilfuel7]

No prob Baron..just glad I can help.

[wanderingmarsupial]

I keep seeing the same study referenced.
Deca= 270% collagen increase
Equipoise = 340% increase
HGH = dose dependent but can be at least as high as 250%

But I can't seem to find the actual study this comes from. Did someone just pull those numbers out of the air and everyone else ran with it or is there a real basis for it. I'm not saying I doubt the claims. My own limited experience with deca proved to me it helps, I just want to know where this science is coming from.

[barondumonde]

Edit.

[wanderingmarsupial]

I've never seen those numbers so I don't think I can say much about where they would be from...

It's here, here, here, here, here. I could keep going, and in some cases they post "originally posted by XXX over at www.'whatever'.com (or .net, or whatever) but I haven't tracked it back to the original author. I was just hoping someone here would know the origins of this.


EDIT: For some reason my first and fourth link are being asterisked out. Perhaps there's something going on I don't know about but trust me, they are real links.

[barondumonde]

Edit.