tamoxifen

[bulkyboy]

can taking tamoxifen all the way thru a cycle stop gains?

[dirtball_619]

no, but it can hinder them. save it for after unless you get side effects

[PT]

it can drop your igf levles

[Merc..]

Check out this thread..

http://forums.steroid.com/showthread...light=estrogen



Merc.

[bulkyboy]

ive never ever had any signs of gyno so there aint much point me taking it thru my cycle is there? as i got advised too just in case.

[bulkyboy]

cheers for that,good read. ill take action now!

[Merc..]

Here is one study on it.. There are alot of studies done on this..


Tamoxifen reduces serum insulin-like growth factor I (IGF-I).Pollak MN, Huynh HT, Lefebvre SP.
McGill University, Montreal, Quebec, Canada.

Antiestrogens are widely used in the management of hormonally responsive breast cancer in both adjuvant and palliative settings, and are currently being evaluated as chemopreventive agents. The classical mechanism of action of these drugs involves inhibition of estrogen-stimulated neoplastic cell proliferation by blockade of estrogen receptors present on breast cancer cells. This paper reviews recent clinical and laboratory data that suggest that the commonly used antiestrogen tamoxifen also acts to reduce serum IGF-I levels. Estrogens appear to play a permissive role in growth hormone (GH) release by the pituitary gland and GH is known to stimulate IGF-I expression by hepatocytes. It is therefore possible that blockade of estrogen receptors in the hypothalamic-pituitary axis by tamoxifen interferes with GH release, leading to reduced hepatic IGF-I expression. In view of results suggesting that IGF-I is a more potent mitogen than estradiol for breast cancer cells and data demonstrating a positive correlation between estrogen receptor level and IGF-I receptor level of breast cancer cells, the IGF-I lowering effect of tamoxifen may contribute to the cytostatic activity of the drug. The interrelationships between steroid hormone physiology and IGF-I physiology may have relevance to a variety of commonly used treatments for hormonally responsive cancers.

PMID: 1421427 [PubMed - indexed for MEDLINE]

[wes cst rydr]

i just take letro the whole time on..but some have problems with that too.

[CheddaNips]

I say follow mercs article and dont use it unless it is needed

[sitries]

my 1st cycle i didnt use it at all and had no problems. but 2nd cycle tried to do the same but developed mild gyno. so had to hit the nolvadex hard! prevention is better then cure - better safe than sorry. id recommend taking 10mg per day durinf the whole cycle.