
Originally Posted by
ladygarn
yes it works. As I understand it, its not really spot reduction so much as its a restoration of normal fat use/burning from that tissue which has abnormally low fat utilization. The A2 receptor, which makes this type of fat stubborn, is basically a kill switch for catecholamine based lipolysis. Topical yohimbine blocks that receptor, thus blocking the kill switch. I beleive that blocking it also increases norepinephrine production as well, though how much more than in "normal beta/alpha ratio tissue, I think it hard to say. So there probably is some spot enhanced reduction as well.
thing with this and any other type of burner, if you calories are not in a deficit, you are kind wasting them. They probably still have some effect, but I would say its limited. The exception would probably be in untrained or detrained people, at least until the adapt to training.