How long does IGF1LR3 remain active in the body?

[jg42058p]

How long does it last until it breaks down and no longer functions?

[datbtrue]

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[Pinnacle]

Possibly true, but gropep claims it's active in cell cultures for upwards 3 days.

[datbtrue]

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[Pinnacle]

Good point. So in practical terms IGF-1 LR3 need only be dosed every other day maybe even every 3rd day.

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Possibly bro, but you'd have to take into account human metabolism as well.

We'll probably never really know. Gropep insists it's harmful for humans if in fact the people are getting actual LR3 right from them.

Further, with millions of market share dollars awaiting Gropep, wouldn't you think they'd market it, if it was in fact safe to use?

[datbtrue]

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[jg42058p]

how is it harmful?

[datbtrue]

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[Deep_Fried]

Potentially so...in short some cancers metastasize and break through natural bounderies by expressing growth factors which fuel their growth.

There are multiple binding proteins for IGF-I & IGF-II which bind to and form a complex with the growth factor. In essence these binding proteins make IGF selective in where it exerts its influence and for how long.

There are binding proteins for GH as well and when there is a rise in GH the result is an increase in synthesis of BOTH IGF-1 & the binding proteins in the liver. The body has checks and balances...

IGF-1 LR3 is a synthetically altered IGF-1. It is altered in such a way as to reduce/eliminate the ability for the binding proteins to bind to & consequently exert an influence on the behavior/action of IGF-1. So IGF-1 LR3 is an unchecked growth factor.

It circulates and acts systemically and has the potential to do good (i.e. repair the lining of my intestines & bile duct) but it is also possible that it may fuel the growth of exhisting cancerous tumors. Using IGF-1 LR3 is NOT a selective process. You do not know where it will exert its influence. You do know that there is a higher affinity in the intestinal tract but there are receptors all over the body to which it could exert an influence.

Studies of cancer patients demonstrate a correlation between cancer & increased levels of IGF-1. It is true that many cancers are able to make their own growth factors...but why make it easy for them by supplying a pool of unchecked IGF-1 in the form of LR3?

Some of the most exciting cancer research involves antagonists for growth factors such as GHRH & IGF-I. These antagonists constucted to target specific types of growth factor producing tumors have been shown to stop tumor growth. When combined with conventional chemotherapy remission & often complete elimination is observed.

But the important point is that GH & IGF-1 have checks on their potential action that may reduce their potential to fuel cancer growth while IGF-1 LR3 does not.

Right on Dat!! Great stuff!

In addition to IGFs fueling the proliferation of cancerous cells, lets not forget the additional action that increases the cancer risk.
Studies show that Igf-1 is also directly responsible in the inhibition of apoptosis in various cell lines with respect to melanomas for example.
There are many mutations that occur on a daily basis in the human body that produce genetically damaged cells that range from less than harmful all the way to possibly downright cancerous... The body counters this via apoptosis, or programmed cell death that can be carried out via a few different pathways. Basically, cancerous cells/tumors would initiate their own programmed necrosis before growing out of control.
It is shown in studies that IGF-1 along with various IGFs directly interferes with apoptosis by promoting cell resistance to apoptotic actions.
This can allow for a higher percentage of cancerous mutations to grow unchecked...

Take Care