legalon 140......silymarin

[john1181]

ok so my source sent me this stuff as a liver protectant for the halotestin...will this lesen the effects of the halo??

[john1181]

comon guys..i hear a whole lot about how a liver protectant hinders gains of the steroid..has anyone any proof of this?

[john1181]

forget it..i found my answer somewhere else..but thanks....heres to all who saw this thread but didnt have an answer...maybe this might help for future eference....

"As far as I know, both Milk Thistle and Liv-52 work well for liver protection. I've heard people claim that Milk Thistle can decrease the strength of oral steroids because it filters the steroid out of the liver, but that would most likely be true of all real liver aides. Milk Thistle, or more specifically Sylibin, inhibits phase 1 and phase 2 enzymes (Cytochromes P450 3A4 AND 2C9). That basically means that it can decrease your body's ability to protect itself against certain carcinogens (they cause tumors) and it can decrease the synthesis of cholesterol in the liver. The whole idea of Milk Thistle decreasing the effectiveness of steroids probably comes from the fact that it inhibits Glutathione. Glutathione is an antioxidant that is important for stopping free radicals and keeping homocysteine levels reasonable. It is also important for the detoxification of methylglyoxal, which is a nasty product of the body's metabolism; that's probably the reason that some people feel sick to their stomach after using Milk Thistle for a while. Homocysteine levels are measured to predict your chances of heart disease and stroke. Homocysteine levels increase rapidly after stopping a steroid cycle too. Despite all of this though, I think Milk Thistle really is a good filter for the liver. I think that all of the negative effects from the Sylibin are probably very small and may not even occur in everyone that uses it. I would recommend using Milk Thistle as liver protection even though I personally like Liv-52 more. *Using B12 can help keep homocyseine levels low too. "

[LATS60]

ok so my source sent me this stuff as a liver protectant for the halotestin...will this lesen the effects of the halo??

No, it won't do anything to protect your liver either.
Thats just what the supp comps and their affiliates tell you, they prey on the bbers insecurities to make loads of money.

[john1181]

this stuff isnt a supplement its medication

[LATS60]

this stuff isnt a supplement its medication

Apologies, you said silymarin i assumed you meant silymarin the herbal supplement.
The only liver medication i'm familiar with is the intravenous one that's give to chemo patients.

Iv'e just read about legalon 140, it is silymarin, got to love the catchy selling point though.

[LATS60]

forget it..i found my answer somewhere else..but thanks....heres to all who saw this thread but didnt have an answer...maybe this might help for future eference....

"As far as I know, both Milk Thistle and Liv-52 work well for liver protection. I've heard people claim that Milk Thistle can decrease the strength of oral steroids because it filters the steroid out of the liver, but that would most likely be true of all real liver aides. Milk Thistle, or more specifically Sylibin, inhibits phase 1 and phase 2 enzymes (Cytochromes P450 3A4 AND 2C9). That basically means that it can decrease your body's ability to protect itself against certain carcinogens (they cause tumors) and it can decrease the synthesis of cholesterol in the liver. The whole idea of Milk Thistle decreasing the effectiveness of steroids probably comes from the fact that it inhibits Glutathione. Glutathione is an antioxidant that is important for stopping free radicals and keeping homocysteine levels reasonable. It is also important for the detoxification of methylglyoxal, which is a nasty product of the body's metabolism; that's probably the reason that some people feel sick to their stomach after using Milk Thistle for a while. Homocysteine levels are measured to predict your chances of heart disease and stroke. Homocysteine levels increase rapidly after stopping a steroid cycle too. Despite all of this though, I think Milk Thistle really is a good filter for the liver. I think that all of the negative effects from the Sylibin are probably very small and may not even occur in everyone that uses it. I would recommend using Milk Thistle as liver protection even though I personally like Liv-52 more. *Using B12 can help keep homocyseine levels low too. "

Where do you keep finding these bits to cut and paste.
Because a lot of this one is pure speculation. So i can't see how it might help for future reference

[john1181]

well bro since i cant find much science on the topic this theory pretty much covered up the side of not using anything while on cycle..thts me tho..others might seeit differently..it could still serve as a half reference to make one decide whats best for him

[john1181]

what do you think about this?

"Sulphasalazine Can Reverse Liver Disease Even For Heavy Drinkers
Featured Article
Main Category: Liver Disease / Hepatitis
Also Included In: Alcohol / Addiction / Illegal Drugs; Clinical Trials / Drug Trials; Transplants / Organ Donations
Article Date: 26 Sep 2006 - 9:00 PDT

--------------------------------------------------------------------------------
Cirrhosis of the Liver


Surgical techniques
Living-donor liver transplantation by Kyoto Univ English text in color
www.prous.com/transplantation/eg

Sulphasalazine, a cheap drug currently used for arthritis and IBD (inflammatory bowel disease) can reverse the scarring that comes with cirrhosis of the liver, say scientists from the University of Newcastle, UK. Doctors had always thought that fibrosis - scarring associated with cirrhosis - was irreversible. This new study on animals has shown the damage can be reversed with Sulphasalazine.

In the UK, about 10% of the adult population have liver problems, mainly due to heavy drinking and obesity/overweight.

The liver has hepatic myofibrobrlasts, these are cells that create scar tissue when the organ is injured. Hepatic myofibrobrlasts produce proteins which makes it more difficult to break down the scar tissue. In a healthy liver the scars gradually disappear and new healthy ones replace them. This does not happen when the liver tissue is diseased - and the scar tissue spreads.

The scientists found that Sulphasalazine stops the hepatic myofibrobrlasts from producing the protein that protects the scar tissue cells. In other words, it helps the scar tissue to gradually melt away.

If human trials show similar results, it could mean treating and-stage patients with Sulphasalazine rather than having them undergo a liver transplant. The scientists say they will start trials with heavy drinkers who no longer drink, but whose livers are not able to recover on their own.

This drug could be a Godsend for alcoholics who have given up drinking. Even a seemingly small recovery of 10% can make a huge difference to the patient's general health and quality of life, say the researchers.

The researchers say Sulphasalazine could halve the cirrhosis death rate in the UK. Treatment would cost �10 ($18.50) per week.

Some Facts About Cirrhosis

-- Responsible for 1.4 million deaths per year worldwide
-- Responsible for 5,000 - 10,000 deaths per year in the UK
-- Early stages are symptom free (so damage accumulates unnoticed)
-- There is currently no cure. The only end-stage treatment is a liver transplant
-- Most common causes are Hepatitis C (globally) and excessive alcohol consumption (developed countries)
-- Scotland has particularly high rates among developed countries"

[john1181]

turns out sulfasalazine is the worst on the liver...

"See also Disease-modifying antirheumatic drugs for its role in rheumatoid arthritis
Sulfasalazine is mainly used for treatment of inflammatory bowel disease, including ulcerative colitis and Crohn's disease. It is also effective in several types of arthritis, particularly rheumatoid arthritis.

However, in recent British research involving animal studies, and more recently, human trials for the treatment of chronic alcoholics, sulfasalazine has been found to reverse the scarring associated with cirrhosis of the liver. Apparently, cells called myofibroblasts, that cause scar tissue to form in a diseased liver, also give off proteins that prevent the breakdown of the scar tissue. Sulfasalazine appears to retard the secretion of these proteins.

According to the findings of a case series published in BMC Musculoskeletal Disorders, the use of sulfasalazine in the treatment of inflammatory arthritis can result in serious hepatotoxicity - an adverse effect which appears to be ‘under-appreciated’ in practice.

The results are from a local reporting system, which was set up in 2000 to look further into adverse drug reactions (ADRs) associated with disease-modifying antirheumatic drugs (DMARDs). The authors describe a series of 10 patients who developed serious hepatotoxicity whilst taking sulfasalazine. All had normal liver function tests (LFTs) prior to initiation of sulfasalazine, and none started any other new medications at the time of starting sulfasalazine. All patients however were using other drugs when sulfasalazine was started; in some cases this included other potentially hepatotoxic drugs.

Eight of the ten patients were hospitalised; three were admitted to the regional liver unit, including two with hepatic failure who received liver transplants. One case was fatal. Other causes of hepatitis were considered and investigated but exhaustive investigations were not done in all cases. All but one event occurred within 6 weeks of starting treatment. Likelihood of drug-related hepatotoxicity was judged highly probable in 7; probable in 1; and possible in 2 cases by two senior clinicians."

[-Ender-]

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