New study I've found here:
1: J Androl. 2009 Apr 2.
The Dark Side of Testosterone Deficiency: III. Cardiovascular Disease.
Traish AM, Saad F, Feeley RJ, Guay AT.
A considerable body of evidence exists suggesting that androgen deficiency contributes to the onset and/or progression of cardiovascular disease (CVD). It is our objective to evaluate the relationships between Testosterone (T) deficiency and risk factors of cardiovascular disease (CVD) and to discuss the implications of androgen deficiency in men with cardiovascular risk factors. The relationship between androgen deficiency and endothelial function, lipid profiles, inflammatory responses, altered smooth muscle and hypertension are discussed with regard to CVD. A comprehensive literature search was carried out using Pub Med from 1980 through 2008 and relevant articles pertinent to androgen deficiency and vascular disease were evaluated and discussed. Low testosterone, whether attributed to hypogonadism or androgen deprivation therapy (ADT), in men with prostate carcinoma, produces adverse effects on cardiovascular health. Androgen deficiency is associated with increased levels of total cholesterol, low density lipoprotein (LDL), increased production of pro-inflammatory factors, increases thickness of the arterial wall, and contributes to endothelial dysfunction. T supplementation restores arterial vasoreactivity, reduces pro-inflammatory cytokines, total cholesterol, and triglyceride levels and improves endothelial function, but may also reduce high density lipoprotein (HDL) levels. In conclusion, T is an anabolic hormone with a wide range of beneficial effects on men's health. The therapeutic role of T in men's health, however, remains a hotly debated issue for a number of reasons, including the purported risk of prostate cancer. In view of the emerging evidence suggesting that androgen deficiency is a risk factor for CVD, androgen replacement therapy may potentially reduce CVD risk in hypogonadal men. It should be emphasized, however, that androgen replacement therapy should be done with very thorough and careful monitoring for prostate diseases.
PMID: 19342698
So androgen deficiency probably contributes to the onset and/or progression of cardiovascular disease (CVD). This was a 28 year study here too!
I quote, "Androgen deficiency is associated with increased levels of total cholesterol, low density lipoprotein (LDL), increased production of pro-inflammatory factors, increases thickness of the arterial wall, and contributes to endothelial dysfunction". And, may I add, CVD. Thats quite a list there, for having low testosterone levels.
It obvious these effects wont manifest themselves during PCT. But this thread is aimed at the people who may have low endogenous testosterone levels through steroud use/abuse over many years. Many of use have messed up HPTA's now and these side effects (above) are very real. I get PMs dialy from users who have low sex drives months, even years, after using AS and completing a lengthy PCT.
If your sex drive DOES NOT return after PCT get bloodwork done! You should be getting it anyway, its essential to use steroid users/bodybuilders.
This thread is also an example of the effects you may one day experience if you do not run a proper PCT. The PCT sticky's are there to be read. So read them. Because these lasting effects on the HPTA are real, evident and happening.
If you think you have have AD (androgen deficiency) and have run a fair few PCT's with no luck, see your doctor or endocrinologist.
Symtoms of AD are:
Circulation and the nervous system
- hot flushes
- sweating
- insomnia
- nervousness.
Mood and cognitive (higher mental) function
- irritability and tiredness
- decreased sense of well-being
- lack of motivation
- low mental energy
- difficulty with short-term memory
- depression
- low self-esteem
- being easily frightened, reduce confidence
Masculinity and virility
- decreased vigour and physical energy
- diminished muscle strength.
Sexuality
- decreased interest in or desire for sex (low labido)
- less sexual activity
- poor erections
- reduced quality of orgasm
- weakness of ejaculation
- reduced volume of ejaculated fluid.
Physical features include
- diminished muscle mass
- loss of body hair
- abdominal obesity.
Several other effects on body chemistry and metabolism occur, such as:
- Reduction in high-density lipoprotein (HDL) cholesterol and increase in low-density lipoprotein (LDL) cholesterol, which increases the risk of developing coronary artery disease.
- Increase in total body fat (because of a fall in the proportion of body weight that is muscle rather than through weight gain).
- Osteoporosis (a change in bone structure and strength that predisposes the sufferer to fractures, particularly of the wrist, hip and spine).
- reduction in red cell volume (a reduction in the proportion of red blood cells to plasma.
(http://www.netdoctor.co.uk/menshealt...emenopause.htm)
Use, dont abuse and run a decent PCT.
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Yupper!
Originally Posted by Swifto
