Fat loss drug by an unknown mechanism

[marcus300]

I am going to put this in here because the lack of traffic in the supp section.
This makes very interesting reading, this compound induces weight reduction by an unknown mechanism!!

Migraine drug cuts fat

Topiramate is used to treat migraine headaches. German researchers discovered that it also reduced bodyfat and enhanced metabolic health.They gave 100milligrams of the drug per day to six patients for 20 weeks, which reduced body mass index (proportion of weight to height) by 7%. Body fat by 12% waist circumferance by 4%, leptin (controls appetite and metabloic rate) by 39% and insulin resistance by 37%. It increased adiponectin (helps cntrol blood sugar and fat deposit) by 70%. Topiramate decreased body fat and improved metabolic health.
(Experimental & Clinical Endocrinology & Diabetes,in press: Published online March 3 2010)

[BJJ]

Do not you have the complete study on it?

[marcus300]

Do not you have the complete study on it?

Abstract https://www.thieme-connect.com/DOI/D...s-0030-1248289

[marcus300]

Ive just done abit of research on the side effects because I thought there must be some with those results:

Side effects may include:
Abdominal pain, abnormal coordination, abnormal vision, agitation, anorexia, anxiety, appetite loss, back pain, breast pain, chest pain, confusion, constipation, depression, difficulty with concentration, difficulty with memory, dizziness, double vision, drowsiness, fatigue, flu-like symptoms, indigestion, language problems, leg pain, loss of coordination, menstrual problems, mood problems, nausea, nervousness, nose inflammation, rash, sinusitis, slowing of movements, sore throat, speech problems, tingling or burning sensations, tremors, weakness, weight loss

[BJJ]

The question now is, will that drug has the same effect on a healthy lean body type?

[gymfu]

Yea, I'm thinking that the loss of appetite might have helped some rather out of shape indivduals.
But still interisting thanks marcus as always good stuff!

[wolffish]

Topiramate is also an epilepsy drug and it makes most people a bit thick.. as in makes their brain work slower than usual (or as my mate says, 'makes her stupid'). people i know who've taken it have really not enoyed it =(

[dec11]

nice, i get prescribed migraine meds, must check that stuff out. good find mate, cheers

[Nicotine]

sweet, sign me up to be a guinea pig

[RED26]

wow, that stuff about epilepsy drugs just made some things clearer for me (as in comprehending some friends stupidity)

[marcus300]

Anyone willing to give it a go and log the results?