T3 half life question???

[matt77]

This question is geared more for a VET or the very well informed to answer.

So why is it that every cycle plan with T3 everyone always uses ED dosing vs. EOD? The half life of T3 is about 2.5 days. So one would think EOD dosing would be the way to go. I have been trying to find solid answer to this with little luck without posting a new thread.

[HawaiianPride.]

2.5 days? Try 10 hours lol.

Sorry, I'm not in green, but I do know a thing or two about half lives

[Sector]

2.5 days? Try 10 hours lol.

Sorry, I'm not in green, but I do know a thing or two about half lives

This is why most people split their dose AM/PM.

[Atomini]

2.5 days? Try 10 hours lol.

Sorry, I'm not in green, but I do know a thing or two about half lives

It's interesting, i've seen in mutiple places that T3's half life is 2.5 days, and in many other places that the half life is 10 days.

Lots of misinformation floating around out there... hard to discern the truth from everything.

[matt77]

2.5 days? Try 10 hours lol.

Sorry, I'm not in green, but I do know a thing or two about half lives

This is why most people split their dose AM/PM.

Well guys Im not trying to argue but the reason I asked is because thats what the FDA states. I copied this straight from the FDA on T3.

Pharmacokinetics

Since liothyronine sodium (T3) is not firmly bound to serum protein, it is readily available to body tissues. The onset of activity of liothyronine sodium is rapid, occurring within a few hours. Maximum pharmacologic response occurs within 2 or 3 days, providing early clinical response. The biological half-life is about 2-1/2 days.

T3 is almost totally absorbed, 95 percent in 4 hours. The hormones contained in the natural preparations are absorbed in a manner similar to the synthetic hormones.

[HawaiianPride.]

You'll get FDA and Wikipedia saying one thing, and pubmed, emedicine, webmd, and AAS books that say another. I get my information from the most highly regarded and newly updated. http://forums.steroid.com/showthread...s-PLEASE-READ* My sources from that thread are just under a year old. How old is that source? Either way, I still believe the half life is within 1 day for T3 where as T4 being more active and abundant has a much longer half life.

[matt77]

Well honestly then I guess no one knows! FDA and King Pharmaceuticals have the exact same pharmacokinetics profile I thought it would be accurate. King makes Cytomel so who knows??? The profile is what is currently posted on for both but I do not know when it was written.