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Q: I'm in my late 30's and I've been receiving 400 mg of Test depot every three weeks. However, my nuts have shrunk. Obviously, I'm experiencing some negative feedback. Would I do well to quit the T for awhile and undergo some hCG therapy? How much? How long?
A: I'm adamantly against the use of hCG in order to restore testicular function. Why? Simply put, it doesn't do that!
Not only that, but it can actually cause down-regulation of LH/hCG receptors which would cause the testicles to become less responsive to therapy in the future as well as to your own LH. If done long enough, you'll have hypogonadism which won't be able to be treated since your testicles won't respond to LH.
The only other option is Testosterone therapy for the rest of your life. I've been preaching this for some time now, but people don't seem to listen. Again, recently it was shown that in men who used hCG, LH was reduced significantly, as was FSH. So, in fact, what you're doing is further prolonging the process of recovery by using hCG.
Is there a time when hCG is actually warranted? Well, I suppose if you can't stand to have low testicular volume during a cycle then you can use it, but ultimately, you're doing much more harm than good. The other reason would probably be if you're wishing to get your wife pregnant. Other than that, I don't, nor will I ever recommend the use of hCG as things like clomiphene and letrozole actually work to correct the problem. (36)
hCG: More Bad News
Q: A friend of mine undergoes concurrent T and hCG therapy, long-term. Any dangers of this protocol?
A: As I mentioned above I'm strongly against the use of hCG. As far as dangers, there aren't any immediate dangers aside from possible gynecomastia. Still, this protocol is likely to cause longer suppression and perhaps even a slight and permanent loss of testicular responsiveness to LH/hCG because of the usage of hCG.
And here's a link to the study at the bottom of the page: http://jcem.endojournals.org/cgi/reprint/87/7/3125
Opinions?
I noticed in the study they were giving the men 5000iu biweekly. Everywhere I've read it suggests something closer to 250iu biweekly to maintain your balls, is this the dose u guys use?? I'm hoping it's the incredibly high dosage that's causing the problems.
Or maybe I'll be surprised to find most of you guys are anti-HCG, who knows![]()