Letrozole question

[patjza80]

I've been On TRT for about a year and a half now. My test levels stay around 1050 or so with a 200 a week. Even at these levels my energy was crashing in the middle of the day and sex drive was low.

I switched doctors.

I Told the current doctor what was going. I did a blood test that day, but before the results came back she prescribed letrozole and told me to take 1.25 a week and let's see what happens. She thought maybe the estrogen was too high and killing my energy and sex drive.

So while waiting for the blood test I took the first pill. Energy was INSTANTLY increased, but I felt a bit more emotional, and I felt like my sex drive was decreased a tiny bit more. After about day 4ish energy was gone.

Test results came back and my estrogen was a 44 and test was 490. Between switching doctors I didn't have a shot for 9 days so my levels had dropped.

Following week I decided to cut the dosage of letrozole in half.
.625 mg every 4 days. I killed my sex drive to almost nothing and energy was not as great.

What am I doing wrong? All I want is a sex drive again!!!

[zaggahamma]

letro is an unusual compound with trt doses for one...its usually too harsh and brings e2 levels down to far..arimidex is the most popular and aromasin a close second.....

in addition there are other important hormones that can be effected when/from injecting test...hcg is being shown to be pretty much a must have as well in your trt arsenal for long term nirvana

[GotNoBlueMilk]

Actually, there is a lot of misconceptions out there about letro. This is due to the fact that the company published a bunch of studies showing how strong it was; however, you have to read the fine print of the study. In-vitro it is super strong! But we don't use letro in a test tube full of estrogen we use it in our body. In real life usage, it is only about 20% stronger than Anastrazole; however, you have to take 2.5 times (2.5 mg) the amount of letro than you do Anastrazole (1.0 mg) to accomplish this result. So when we take it in moderate amounts, say 0.5mg EOD, it isn't that much stronger than taking 0.5mg of Anastrazole.

The other thing you have to pay attention to is was the study done in men, pre-menoposal or post-menopasal women? Studies on pre-menoposal women are irrelevant to males! Turns out Letro is great on pre-menoposal women and average on both post-menoposal women and males! From this we can conclude that Letro is better at reducing E2 prodcution in ovaries than blocking it in fat cells. That most frequently quoted study of "reduing E2 levels by up to 98% or more" was based on a study on pre-menoposal women! And pay attention to the "up to" part. If one single pre-menoposal woman had E2 levels reduced by 98% but the rest of the women had E2 levels reduced by a small amount, what good would the drug be unless you are that one woman? Other studies claim great reduction in E2 levels but when you read the fine print it says "doses up to 5 mg/day". Hell, you take enough of any AI and your E2 levels are going to be non-existent.

In this study http://jcem.endojournals.org/content.../5717.abstract young and old men were given 2.5 mg/day of Letro. After 28 days, the E2 levels had decreased by 46% in young men and by 62% in elderly men (old men don't produce as much E2 in the leydig cells, proving Letro is more affective in fat cells than leydig cells). Now the above study was to test Letro on T production due to LH increase. But the E2 results speak for themselves.

I take letro for my AI. I do not tolerate Anastrozole very well. It makes me irritable, depressed, and when combined with a sugar rush I really feel bad. Right now I do 80 mg Test Cyp per week and I take 0.20 mg of Letro twice a week.

1.25 a week of Letro is a crappy prescription. The stuff has a half life of about 3 days. So you will drop your E2 levels significantly on day 1, then the levels will creep up and by about day 4 you may start having issues again. This is going to put you on an E2 roller coaster ride. You need to break this out to every other day, or at least twice a week.

[zaggahamma]

Actually, there is a lot of misconceptions out there about letro. This is due to the fact that the company published a bunch of studies showing how strong it was; however, you have to read the fine print of the study. In-vitro it is super strong! But we don't use letro in a test tube full of estrogen we use it in our body. In real life usage, it is only about 20% stronger than Anastrazole; however, you have to take 2.5 times (2.5 mg) the amount of letro than you do Anastrazole (1.0 mg) to accomplish this result. So when we take it in moderate amounts, say 0.5mg EOD, it isn't that much stronger than taking 0.5mg of Anastrazole.

The other thing you have to pay attention to is was the study done in men, pre-menoposal or post-menopasal women? Studies on pre-menoposal women are irrelevant to males! Turns out Letro is great on pre-menoposal women and average on both post-menoposal women and males! From this we can conclude that Letro is better at reducing E2 prodcution in ovaries than blocking it in fat cells. That most frequently quoted study of "reduing E2 levels by up to 98% or more" was based on a study on pre-menoposal women! And pay attention to the "up to" part. If one single pre-menoposal woman had E2 levels reduced by 98% but the rest of the women had E2 levels reduced by a small amount, what good would the drug be unless you are that one woman? Other studies claim great reduction in E2 levels but when you read the fine print it says "doses up to 5 mg/day". Hell, you take enough of any AI and your E2 levels are going to be non-existent.

In this study http://jcem.endojournals.org/content.../5717.abstract young and old men were given 2.5 mg/day of Letro. After 28 days, the E2 levels had decreased by 46% in young men and by 62% in elderly men (old men don't produce as much E2 in the leydig cells, proving Letro is more affective in fat cells than leydig cells). Now the above study was to test Letro on T production due to LH increase. But the E2 results speak for themselves.

I take letro for my AI. I do not tolerate Anastrozole very well. It makes me irritable, depressed, and when combined with a sugar rush I really feel bad. Right now I do 80 mg Test Cyp per week and I take 0.20 mg of Letro twice a week.

1.25 a week of Letro is a crappy prescription. The stuff has a half life of about 3 days. So you will drop your E2 levels significantly on day 1, then the levels will creep up and by about day 4 you may start having issues again. This is going to put you on an E2 roller coaster ride. You need to break this out to every other day, or at least twice a week.

great post gnbm

[patjza80]

I'm thinking I'm going to try to switch over arimidex since it's easier to keep levels from getting to low.
What would be an appropriate dosage for arimidex? Like .5mg every couple days?

[zaggahamma]

if your e2 is at 44 i wouldnt even do that much....you can cut them in quarters and do .25 eod...but you WILL have to find what dose is best for you..

trt is individual