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Clin Chim Acta. 2011 Jul 12. [Epub ahead of print]

A novel case of a raised testosterone and LH in a young man.

McDonald TJ, Perry MH, Jones AG, Donohoe M, Salzmann MB, O'Connor J.
SourceClinical Chemistry, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.

Abstract
A 19year old male attended his GP with a history of "fluid retention", lack of libido and erectile dysfunction. He was found to have a high serum testosterone, and a raised luteinising hormone. After further investigations, the patient admitted to taking a supplement called ActivaTe Xtreme™, obtained from an internet source, to address his low libido. ActivaTe Xtreme™ contains active ingredients which increase serum testosterone levels by several independent mechanisms that are not associated with luteinising hormone suppression. Urine analyses for synthetic anabolic steroids were negative, and urinary testosterone, epitestosterone and other androgens were normal. This biochemical pattern is not the same as that seen with anabolic steroids (i.e. raised testosterone, suppressed luteinising hormone and abnormal urine steroid profile). The issue of self medication with performance enhancing compounds needs to be carefully considered in order to avoid expensive and invasive investigations, missing an underlying pathology or misdiagnosing a patient. This case also raises the spectre of yet another "performance enhancing" product that may cause difficulty for those trying to ensure that sport remains on a "hormonally" equal basis.

Copyright © 2011. Published by Elsevier B.V.

PMID:21756889[PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/21756889



Supplement is Activate Extreme by Driven Sports.

Its only one subject, but seems to show an increase in "serum testosterone".

Ingredients:

Activate Xtreme Ingredients:
Serving Size: 2 Capsules
Servings per Container: 60

Amount Per Serving % Daily Value
Vitamin D3 (as D3 Cholecalciferol) 2000 IU 500%
Activate Xtreme Propietary Blend:
1500 mg **
CoreTest:

Divanil (Propietary Urtica Dioica Extract containing SHBG Binding and Aromatase Inhibiting Lignana Including 3,4-Divanillyltetrahydrofuran Secoisolariciresinol), Mucuna Pruriens SE (20% L-Dopa), Maca Root PE 20:1 (Lepidium Meyenii)
**
LevoTest:

Bryonia Laciniosa Seed PE 10:1, L-Dopa (standarized 95% Extract of Mucuna Pruriens, pZole ((Propietary Extract of Brassaiopsis Glumerulata), Vitamin D (as D3 Cholecalciferol) **

* Percent Daily Values are based on a 2000 calorie diet.
** Percent Daily Values not established.

OTHER INGREDIENTS: Magnesium Stearate, Rice Powder, Gelatin


Activate Xtreme Recommended Use:
Take 1 serving 2-3 times per day. For best results, use for 4 to 8 weeks. Do not exceed 8 weeks of continuous use.


Nothing out of the ordinary in there, but something worked for him.