A conversation about half life

[txnhb]

I am not trying to write a scholarly, however I thought I would share a conversation I had with my professor about half life's. His background is a PhD from Harvard in biochemistry. We were covering it in class and so it prompted me to wonder how half life's work in medicine.
I assume the veterans on here are well aware of how half life works in medication. For those who are not it is simply the amount of time it takes for a concentration to reduce by half. How they derive that half life is what is interesting.
It is different than how it is derived from chemistry. In medicine it is more of a statistical analysis. A certain sample size X amount, is given the medication being tested. From there blood is drawn to see how much of the concentration is left in the blood. Much more simply stated however that is the basic run down of the process.
This is interesting since there seems to be some argument on how we on TRT feel about biweekly, weekly etc injections. Since there is a sample size taken to derive half life it might be safe to say there are people who react differently on medication. The only way to determine this is what we already all do which is draw our own blood to determine our levels while on TRT.
Just thought I'd share guys. Hope everybody is ready for the weekend!

[flatscat]

Nice post. And timely.

We all react to and process things differently. I have always thought the discussions we have here on the half life of hormones is generic and totally subjective and should not be taken as fact.

[HRTstudent]

well absolutely pharmacodynamics is far more complex than something like chemical half lifes. people all have their own metabolisms and there are always people to either side of the belll curve... that's what makes it a bell afterall

[txnhb]

Exactly he said were not test tubes ha