
Originally Posted by
Capebuffalo
This is where things get sticky, you will complete a PCT (post cycle therapy) after your cycle you should use a prescription grade PCT consisting of i.e Nolvadex (Tamoxifen Citrate).
Nolvadex uses an enzyme 'CYP2D6? to convert itself into a more useful form that our bodies can use. Unfortunately many antidepressants also use this same CYP2D6 enzyme, thus you have two medications competing for the same pathway. The problem? Antidepressants have priority on the CYP2D6 enzyme therefore can render Nolvadex to be nearly useless, which could cause serious side effects during our PCT such as Gynecomastia. If you're on an antidepressant and intend on using Nolvadex as your PCT, it's important for you to know which antidepressants will cause issue and if you're on an antidepressant that will inhibit Nolvadex from being functional, I recommend going with Clomid or Fareston , but is that enough ? I will let a vet chime in at this point with a better understanding.