There really is no difference. I have done some of the research myself and found that the jury is still out on which one is 'better'.
TUDCA is UDCA with a taurine amino acid chemically bound to the UDCA molecule. Hence the name
Tauroursodeoxycholic acid. TUDCA is the taurine conjugate of ursodeoxycholic acid. It simply converts to UDCA when in your body.
There have been claims made that TUDCA is 'superior' to UDCA in bioavailability to the body, but ultimately this has never been proven. In the end, they're the same damn thing.
Someone in another thread asked if supplementing taurine with UDCA would be the same thing as taking TUDCA. Supplementing taurine with it is NOT the same as it being tauroursodeoxycholic acid, where the taurine amino acid is actually
chemically bonded to the ursodeoxycholic acid structure. That's like saying throwing wheels in the back of the trunk of your car is the same thing as driving with the wheels ON the car. As I mentioned prior, TUDCA is touted to provide superior bioavailability over straight UDCA. But it hasn't been proven.
TUDCA is just a conjugate of UDCA. They are the exact same thing, they do the same job, they are reduced to the same stuff when processed in the GI tract.
http://onlinelibrary.wiley.com/doi/1...030.x/abstract
http://www.gastrojournal.org/article...*45-3/abstract
From the first link:
Conclusions
After oral administration of TUDCA and UDCA, no significant differences in their absorption and in biliary bile acid secretion exist. Whether biliary enrichment with taurine conjugates of UDCA instead of glycine conjugates offers advantages in the treatment of cholestatic liver disease is unclear at present.
From the second link:
COnclusions: Low doses of TUDCA and UDCA protect Hep G2 cells from EtOH-induced cytotoxicity. However, TUDCA seems to be more effective than UDCA in reversing the damage.