Nolva and SSRI problem....

[lifeofdefiance]

Hi, I'm gonna be running a test/tren cycle soon and my planned PCT was

Nolva 40/20/20/20
Clomid 100/50/50/50

However I read that Prozac competes for the same enzyme as nolva making it relatively ineffective, so I'm wondering what I should do for PCT now instead? Any thoughts?

[lifeofdefiance]

Also, while we're on the subject, does anyone know if prozac is fine to run with other things such as adex and dostinex. I'll be running both of these during my cycle. I haven't seen anything on drug interactions between them, but I just happened to stumble upon the fact that prozac and nolva had an interaction. Wish I could get off the stuff, but I just started a month ago for anxiety and would rather not have to.

EDIT: Actually found out caber can help with prolactin already raised by prozac. Wasn't aware SSRI's raised prolactin, well at least i don't have to worry about negative interactions there.

[Lemonada8]

Adex and caber should be fine with nolva and no dose adjustments.

Prozac will inhibit the enzymes in the liver that metabolize tamoxifen, and the active form of tamoxifen is done at the liver: resulting in lower active metabolites of tamoxifen ( meaning you would have to take more to get the same effect)

Instead of nolva, use Tore. The CYP2D6 enzyme inhibition from prozac ( fluoxetine) doesnt interfere nearly the same with Tore compared to nolva.

http://onlinelibrary.wiley.com/doi/1...nticated=false

"Role and pharmacologic significance of cytochrome P-450 2D6 in oxidative metabolism of toremifene and tamoxifen"