The Negative Effects of a Low Carb, High Protein, High Fat diet.

[austinite]

Vascular Medicine and Metabolism Unit, Lipids and Atherosclerosis Research Unit, Sant Joan University Hospital, Institut d'Investigació Sanitària Pere Virgili (IISPV), Faculty of Medicine, Universitat Rovira i Virgili, Spanish Biomedical Research Network in Diabetes and Associated Metabolic Disorders (CIBERDEM), Barcelona, Spain.

Negative effect of a low-carbohydrate, high-protein, high-fat diet on small peripheral artery reactivity in patients with increased cardiovascular risk.

Low-carbohydrate diets have become increasingly popular for weight loss. Although they may improve some metabolic markers, particularly in type 2 diabetes mellitus (T2D) or the metabolic syndrome (MS), their net effect on arterial wall function remains unclear. The objective was to evaluate the relation between dietary macronutrient composition and the small artery reactive hyperaemia index (saRHI), a marker of small artery endothelial function, in a cohort of patients at increased cardiovascular (CV) risk.

The present cross-sectional study included 247 patients. Diet was evaluated by a 3-d food-intake register and reduced to a novel low-carbohydrate diet score (LCDS). Physical examination, demographic, biochemical and anthropometry parameters were recorded, and the saRHI was measured in each patient. Individuals in the lowest LCDS quartile (Q1, 45 % carbohydrate; 20 % protein; 32 % fat) had higher saRHI values than those in the top quartile (Q4, 29 % carbohydrate, 24 % protein, 40 % fat; 1.66 (sd 0.41) v. 1.52 (sd 0.22), P= 0.037). These results were particularly strong in patients with the MS (Q1 = 1.82 (sd 0.32) v. Q4 = 1.61 (sd 027); P= 0.021) and T2D (Q1 = 1.78 (sd 0.31) v. Q4 = 1.62 (sd 0.35); P= 0.011).

Multivariate analysis demonstrated that individuals in the highest LCDS quartile had a significantly negative coefficient of saRHI, which was independent of confounders (OR -0.85; 95 % CI 0.19, 0.92; P= 0.031). These findings suggest that a dietary pattern characterised by a low amount of carbohydrate, but high amounts of protein and fat, is associated with a poorer small artery vascular reactivity in patients with increased CV risk.

source: Negative effect of a low-carbohydrate, high-protei... [Br J Nutr. 2013] - PubMed - NCBI

[RaginCajun]

Nice study

Would like to see one with clients who have no PAD, heart disease, and normal/regulated cholesterol

[gbrice75]

Considering the fact that the carbohydrate is the only macronutrient that isn't essential, I have to question studies like this. Having said that, 'essential' and 'optimal' don't mean the same thing.

[--->>405<<---]

that would freaking figure seeing as how it is the diet I do !! dammit!!! LOL.

cocksuckers cant let me have anything can they!!??!?!

[tarmyg]

Very interesting read indeed. I do not fall into the risk group and my values have always been great but if you are already in a high risk group for cardiovascular disease one should pay close attention.