B12 injection questions

[EverettCD]

I am about to start B12 IM injections tomorrow. Is there any benefit or good reasons to inject SubQ vs IM?

[crazy mike]

May I ask you what kind you have gotten. Mgs and such ? ..crazy mike

[austinite]

Both are good methods of delivery. If your dose has a volume higher than 0.6ml, go with IM injections to avoid lumps in SubQ fat. Otherwise, SubQ is easy. I do it SubQ because it's mixed with my hCG so I get both with one shot.

[EverettCD]

May I ask you what kind you have gotten. Mgs and such ? ..crazy mike

Cyanocobalamin 1000mcg/ml

[EverettCD]

Both are good methods of delivery. If your dose has a volume higher than 0.6ml, go with IM injections to avoid lumps in SubQ fat. Otherwise, SubQ is easy. I do it SubQ because it's mixed with my hCG so I get both with one shot.

Good deal. Thank you, I was thinking SubQ might absorb a little slower but from what I've read it's not that big of a deal.

[Sfla80]

Both are good methods of delivery. If your dose has a volume higher than 0.6ml, go with IM injections to avoid lumps in SubQ fat. Otherwise, SubQ is easy. I do it SubQ because it's mixed with my hCG so I get both with one shot.

Aust I saw you post this before that u mix hcg and b12. Just so im clear do you substitute bas water with b12? Or r u drawing into same pin like u would test/deca for example.

I pin subq and just do .5cc 3 times a week off cycle. And thats ar-r b12

[austinite]

Aust I saw you post this before that u mix hcg and b12. Just so im clear do you substitute bas water with b12? Or r u drawing into same pin like u would test/deca for example.

I pin subq and just do .5cc 3 times a week off cycle. And thats ar-r b12

I never use BAC water. Just B12 instead to mix my hCG.

[EverettCD]

I never use BAC water. Just B12 instead to mix my hCG.

That's a cool idea. What ratio do you mix HCG/B12? I would like to try this with my HCG next month when I get my Rx refilled.

[crazy mike]

Ooops thanks man, May I ask why not Methylcobalamin !! ...crazy mike

[austinite]

I put 5ml B12 into 5000 IU hCG. That gives me 1000mcg Methyl B12 and 1000 IU hCG per ML. I get 250 IU/mcg of each per shot.

[austinite]

Hello ? ...crazy mike

What's up buddy? How can I be of service to you?

[EverettCD]

Ooops thanks man !! ...crazy mike

Hey Mike!!! How's it hanging?

[EverettCD]

I put 5ml B12 into 5000 IU hCG. That gives me 1000mcg Methyl B12 and 1000 IU hCG per ML. I get 250 IU/mcg of each per shot.

Thanks Austinite. I'm going to give this a shot with my next HCG vial. That's the same ratio of BAC water to HCG that my compounding pharmacy sends me.

[austinite]

Thanks Austinite. I'm going to give this a shot with my next HCG vial. That's the same ratio of BAC water to HCG that my compounding pharmacy sends me.

2 birds, one stone. Enjoy, pal.

[crazy mike]

You know Austin~ I was going to get something together to write up on Methylcobalamin B-12 and why it is better than the Cyan~ but I never got it together. I had a hard time getting the right documents to tell how it is better delivered thru the Methylene synthesis process.

Would you want to put that together or is it somewhere already written so people can understand the process? It seems that you are more qualified to do that than I am. What do you say Aust~ ? ...crazy mike

[austinite]

Vitamin B12:

This is my favorite additions, on or off cycle, so I'll go into more detail here than the others. There are several methods of delivering B12 to the bloodstream. I'll list them in the order of effectiveness.

1. Intravenously.
2. Intramuscularly or subcutaneously.
3. Sublingual.
4. Oral.

I only recommend intravenous injection if you're an expert. Otherwise; for the average user I recommend either IM or SubQ injections. Sublingual can be effective in high doses and orals are simply weak.

Theres tons of argument about the effectiveness of oral B12 and there are tons of studies that prove this. However, there is not one single study (I've read most studies on PubMed) that would indicate optimum levels. Orals will work to bring a deficient patient into range. Remember the range for most diagnostics agencies is 200 to 1000. So it's easy to get from 180 (deficient) to 200+.

There are several types of B12 that you can use. I'll list them in the most effective order:

1. Methylcobalamin
2. Adenosylcobalamin
3. Hydroxocobalamin
4. Cyanocobalamin

Methylcobalamin is more bioactive than any other and obviously does not require conversion by the body to methyl; the form that's most beneficial to support red cells and your nervous system. This one is necessary to break down homocysteine (breakdown of non-protein amino acids).

Adenosylcobalamin, the second on the list is really just as effective as Methyl. This is because it's also a form that is useful, as other forms of B12 would have to convert to either Adenosyl or Methyl. This one is a key player in metabolic pathways.

Hydroxocobalamin must be converted by your body into methyl in order to be functional as stated above. The conversion process is certainly better than Cyanocobalamin, which is why it's third on the list. Hydroxo typically comes with other B vitamins. Which is important because B6, for example is required for the betterment of B12.

Cyanocobalamin is the one you find in just about every supplement. One of the reasons for that is because it's cheap to produce; making supplements cost effective, but unfortunately, not result effective. It's named Cyano because it's attached to the cyanide molecule. After the conversion process, very little methyl results. Intramuscular is a MUST with Cyano. Orals are not worth it.

If using a sublingual form, you should use no other than Methylcobalamin. Methyl, regardless of the delivery method is superior and most natural to all types. Sublingual doses should be administered at 35 times the dose of an injectable. That was not a typographical error. 35 times the injectable dose, however, dosing frequency would vary. I'll explain in a minute so that I don't end up gallivanting.

Now that we understand the types of B12 and administration methods, let's move onto how B12 actually works and what it does to your body once you introduce it exogenously to your body:

I'll try my best to keep this short. B12 in any form is converted to methyl or adenosyl, where the benefit begins. After conversion they breakdown important amino acids. Once in intestinal absorptive cells, It attaches to specific receptors. This process (depending on administration method) takes about 3 hours. At that stage B12 is circulating in your system and actively binding plasma proteins.

Every member here has probably heard of bodybuilders using B12 as part of their cycle protocols. Even off cycle, it's still being used. Now, you've probably heard that 1000mcg of oral B12 does not equal 1000mcg injected. This is true. And as mentioned earlier in this article, a sublingual dose of Methyl B12 should be 35 times higher. For example, if you dose B12 Methyl with a 1000mcg injection weekly, you would need 35,000 mcg of a sublingual equivalent. But sublingual methods require daily administration. So you would take 5,000mcg daily. While the sublingual yields great results for me, it certainly did not reach satisfactory (to me) serum levels. But still FAR superior to any other sublingual and frankly, even injectable Cyanocobalamin.

Quest Diagnostics range is 200 - 1100 pg/mL. I like to see my levels over 3000 pg/mL.

Here are some more benefits of B12:

1. Increased Energy.
2. Regenerates Red Blood Cells.
3. Healthy Bone Marrow.
4. Healthy Nervous System.
5. Helps Prevent Anemia.
6. Proper cell function.
7. Necessary for macronutrient metabolism (carbs, fats, proteins).
8. Enhances alertness and memory.

[crazy mike]

Ah Ha!!! Now that was good. Austinite Did you just copy my article Austin~ Huh did you......??

Ok I'm kidding ! That was good Austin~ and thanks. After I read up on it and had a better understanding I wanted to try the Methyl~ AS you know and I posted , the Methylcobalamin B-12 worked for me. Really my appetite increased and my energy went thru the roof. It did what we think as lay people think that B-12 will do for them. I don't even use Cyanocobalamin B-12 anymore. Thanks again. ...crazy mike

[austinite]

Ah Ha!!! Now that was good. Austinite Did you just copy my article Austin~ Huh did you......??

Ok I'm kidding ! That was good Austin~ and thanks. After I read up on it and had a better understanding I wanted to try the Methyl~ AS you know and I posted , the Methylcobalamin B-12 worked for me. Really my appetite increased and my energy went thru the roof. It did what we think as lay people think that B-12 will do for them. I don't even use Cyanocobalamin B-12 anymore. Thanks again. ...crazy mike

No copying, all me buddy.

[MajorPectorial]

Only the price of methyl I have problems with ;-(

[austinite]

You get what you pay for.

[crazy mike]

Only the price of methyl I have problems with ;-(

If you get the lozenges or sublingual it isn't hat expensive. But I was taking Cyanocobalamin time release, sublingual, and lozenges and nothing. I got NO benefits at all.

When I switched to the Methyl~ The roof went off. Seriously ! In my case bud I have a little cirrhosis going on and I wasn't getting it absorbed. But sine the Methyl is absorbed differently my body can put it to use. From all I have researched taking the Cyano~ B-12 is like pissing in the north wind compared to the Methylcobalamin B-12. For me the C-B-12 is just a waste of money. I won't take any if that's all I could take. Now that's me after my experience.

This is what I took in from my research and this is also my experience. ...crazy mike

OH, You know I was joking Austin~, ...cm

[FRDave]

Only the price of methyl I have problems with ;-(

NOW branded methyl B-12 - 5000mg is .18-.21 cents per day depending on 60 or 120 count --- cheap! And that's amazon so it can probably be found cheaper, I just use them since I have amazon prime and get free 2 day shipping :-p

[profboy]

Intramuscular is a MUST with Cyano.

been injecting cyano sub-Q for a few weeks, should I switch it up?

to be honest, I think i "felt" more benefit when I was using the methyl sublinguals as opposed to the cyano injections. Maybe i've just gotten used to the feeling?

[t-dogg]

I am about to start B12 IM injections tomorrow. Is there any benefit or good reasons to inject SubQ vs IM?

I'm actually breaking down and using b12 soon. Ordering from the site sponsor while it's on sale. Starting at 1000mcgs a week IM.

[Pete75]

How do you rank product named: Synthelamin – Appetite Stimulator.. It contains 2 different forms of B12 (Hydroxycobalamin 1,200mcg/ml, Cyanacobalamin 800mcg/ml. Total of 2,000mcg/ml).. I ordred that and got it within days (inside EU). I'm not able the get any other injectable B12 vitamins legally. This brand is interesting because it's sold for oral use only and the whole bottle will last almost 1 year..

[austinite]

How do you rank product named: Synthelamin – Appetite Stimulator.. It contains 2 different forms of B12 (Hydroxycobalamin 1,200mcg/ml, Cyanacobalamin 800mcg/ml. Total of 2,000mcg/ml).. I ordred that and got it within days (inside EU). I'm not able the get any other injectable B12 vitamins legally. This brand is interesting because it's sold for oral use only and the whole bottle will last almost 1 year..

It's fine. Methyl is better.

[trikydik]

How long can you keep B12 before it goes bad? I bought some about 6 months ago and never used it..
I am not sure why.... I wanted to get my HRT going before I added something else to my body I guess. It has been in my medicine cabinet at room temp.
Will it go bad???

Is there any reaction with my HRT? Will it mess anything up???

[austinite]

many years. B12 doesn't mess anything up.

[trikydik]

thanks...

[trikydik]

the mayo clinic website lists many doses for men.... Most are daily (50 mcg Cyana), but it also lists a weekly dose (1000 mcg) and a monthly dose... is it better to dose daily or weekly or monthly???

[austinite]

I don't use cyanocobalamin. But when I did, I used 1000 mcg per week off cycle, and 1000 mcg daily on cycle.

[Ashop]

I am about to start B12 IM injections tomorrow. Is there any benefit or good reasons to inject SubQ vs IM?

I always do mine,,,out of preference IM.

[trikydik]

started today - .5ml (500 mcg)

[trikydik]

felt nauseousness starting about 2 hours later and for about 12 hours afterwards... anyone have this reaction?

[austinite]

Nope. Not me.

[EverettCD]

felt nauseousness starting about 2 hours later and for about 12 hours afterwards... anyone have this reaction?

Not me.

Sent from my iPhone that was manufactured in a sweat shop in China®

[trikydik]

Not me.

Sent from my iPhone that was manufactured in a sweat shop in China®

- you forgot to add "with child slave labor"

[Paragon73]

Anyone find a good source for methylcobalamin injectable? I see prices of $100-$200, which seems outrageous for a vitamin.

[austinite]

Methyl is very expensive.

[trikydik]

i have been doing IM (glute) watched a video on sub q... looks a lot easier... thinking about trying it this weekend...