Will Exemestane reduce gyno on cycle

[z06vett]

Hey guy im about to start 50mg dose of Anadrol 50 Im already on test and tren. I planned on starting the A-50 as soon as my Tren is done. Im already taking Amidrex .5mg ed while on the test. Slowly starting a lil gyno effect. Once the Amidrex is done thats about the time ill be taking the a-50. While on a-50 what the best way to reduce gyno effect for this oral. I was thinking Exemestane. Can some one give me some insight about this situation.

[Docd187123]

An AI is used to manage estradiol levels. A SERM is used to to treat gyno. You'd want to use an AI for the entire cycle whether it be adex or aromasin.

[z06vett]

arent serm used for pct mainly.

[Docd187123]

arent serm used for pct mainly.

SERMs are mainly used to treat breast cancer, menopause symptoms, vaginal atrophy, etc but that doesn't mean they don't have other uses such as treating gyno. AI's also have a number of uses the primary one for us would be managing estradiol NOT treating gyno.

[RangerDanger830]

SERMs are mainly used to treat breast cancer, menopause symptoms, vaginal atrophy, etc but that doesn't mean they don't have other uses such as treating gyno. AI's also have a number of uses the primary one for us would be managing estradiol NOT treating gyno.

This gentleman has a gyno reversal thread in the link database sticky. He states Letro is viable for reversing gyno and gives recommended protocol for it. Can you shed some light on the discrepancy between your information and his?

http://forums.steroid.com/educationa...bout-gyno.html

[Docd187123]

This gentleman has a gyno reversal thread in the link database sticky. He states Letro is viable for reversing gyno and gives recommended protocol for it. Can you shed some light on the discrepancy between your information and his?

http://forums.steroid.com/educationa...bout-gyno.html

Using letro to treat gyno is old school IMO. I've seen reports that it's efficacy is somewhere around 40-45% at reversing gyno. To do so though it will crush your E2 levels in order to rob the breast tissue of estrogen and reverse the growth. With your background I'm sure you understand the implications of tanking E2.

On the other hand SERM treatment has been shown to be effective at reversing gyno around 75% of cases (tamox and ralox) while not affecting E2 levels. Again I'm sure you understand how it works: it binds to the receptor in breast tissue acting as an antagonist preventing hyperplasia of the ductal cells.

If I were to choose one option it would be the SERM treatment which has higher efficacy and higher tolerability.

[RangerDanger830]

Using letro to treat gyno is old school IMO. I've seen reports that it's efficacy is somewhere around 40-45% at reversing gyno. To do so though it will crush your E2 levels in order to rob the breast tissue of estrogen and reverse the growth. With your background I'm sure you understand the implications of tanking E2.

On the other hand SERM treatment has been shown to be effective at reversing gyno around 75% of cases (tamox and ralox) while not affecting E2 levels. Again I'm sure you understand how it works: it binds to the receptor in breast tissue acting as an antagonist preventing hyperplasia of the ductal cells.

If I were to choose one option it would be the SERM treatment which has higher efficacy and higher tolerability.

Okay, thanks for the clarification. I have read a few studies on the efficacy of Tamox to treat gyno so I am a pretty firm believer that if anything will reverse gyno, SERMs will. I was still a little taken aback when I read that thread concerning Letro though and haven't really been able to make heads or tails of it since.

[Docd187123]

AI have limited efficacy in the treatment of gynecomastia; hence, they are not recommended as a first line treatment for gynecomastia.[1]

Aromatase inhibitors in male sex

Treatment of gynecomastia with tamoxife - PubMed Mobile

This confirms findings that tamoxifen used in male breast cancer appears to have no serious side effects.11 Tamoxifen appears to be successful, safe, and avoids operation and on present evidence should be regarded as the first line treatment of gynecomastia.

Endocrine treatment of physiological gynaecomastia

When there is significant tenderness or psychosocial morbidity, pharmacological agents can be tried. In a few published reports, the selective estrogen receptor antagonist tamoxifen has been shown to be safe and effective in reducing the size of glandular tissue in persistent pubertal gynecomastia. Lawrence et al. demonstrated a decrease in breast size in 20 out of 22 patients with use of tamoxifen, with 40% showing greater than 50% size reduction. In the same study, the selective estrogen receptor modulator raloxifene achieved an impressive 86% response rate of more than 50% reduction in breast size.[21] Similarly, Derman et al. showed reduction in pain and breast size in all of the 37 boys administered 20 mg per day of tamoxifen.[22] However, despite these positive encouraging results, the studies are difficult to interpret because of the small sample size and absence of a placebo-treated control arm. The experience with aromatase inhibitor anastrozole has been disappointing in persistent pubertal gynecomastia and is not recommended at present.....

It is unclear as to why aromatase inhibitors have not been very successful in the management of gynecomastia. This could be due to the fact that excessive aromatization of androgens to estrogens is not the only cause of relative or absolute excess of estrogens levels in such patients.

http://www.medscape.org/viewarticle/748626_6

Some good reads if you have the time. Like you said, SERMs work plain and simple and work more often than AIs. That and they have less side effects. Makes it a clear cut choice IMO.

[RangerDanger830]

Spring Break here brother, all the time in the world. I will read them in the AM, thanks for the effort.

[Docd187123]

Spring Break here brother, all the time in the world. I will read them in the AM, thanks for the effort.

You and I are more similar than I'd like to imagine if it's spring break time and the first thing you think to do in the morning is readsome studies hahahaha. You're welcome RD, there are plenty more out there too. I just happened to pick he first few that popped up but I've seen many more that I didn't list here.

[kelkel]

Everything doc said. Plus, if it's extremely pesky and doesn't respond as expected to serms alone, consider adding in Andractim along with it. It's a topical DHT cream and applied multiple times per day can make a big difference.

[RangerDanger830]

You and I are more similar than I'd like to imagine if it's spring break time and the first thing you think to do in the morning is readsome studies hahahaha. You're welcome RD, there are plenty more out there too. I just happened to pick he first few that popped up but I've seen many more that I didn't list here.

I guess I never really thought about that. It kind of sounds sad when I think about it. Many of my friends are shocked to find that behind this muscle and gym time I am really just a huge nerd.

[RangerDanger830]

Those were all good reads. I believe the abundance of studies and results in favor SERMs over AIs is overwhelming and the choice is obvious. Sorry if I kind of hijacked this thread z06.

[Docd187123]

I guess I never really thought about that. It kind of sounds sad when I think about it. Many of my friends are shocked to find that behind this muscle and gym time I am really just a huge nerd.

Not sad at all. I'm the same way. Being a jacked nerd is pretty cool if you ask me lol

[RangerDanger830]

I like to think of it as the best of both worlds, muscular and smart

[jdpeters]

Agree on the jacked nerd comment. Knowledge is more powerful than muscles. So to have both... well you know...