Letrozole Monotherapy instead of TRT

[letro]

Hello,

I recently purchased some Letrozole to deal with some pretty bad pubertal gyno (Im 20). Before this I can safely say I have had low testosterone for quite some time but not to the point where I would need to go to a doctor(All speculation since no bloodwork). I smoked marijuana for quite some time and lived a very sedentary lifestyle. I started the letro 2 weeks ago on low doses (1.25mg E3D) and the next few days it felt like I could of been on steroids. I had strong erections, lifting weights in the gym felt amazing, I needed less sleep with vivid dreams, nocturnal erections and long lasting morning wood and I felt very confident/aggressive. Although the great feeling has slightly subsided, for the most part it's still there. I feel great.

After doing some research I found a few info sources and anecdotes on using letro for TRT (which i can't post on this forum for some reason) but there is still very little on it's use for TRT


So I have a few questions. Do the effects of letrozole diminish over time? Will i need to keep upping my dose?
Are there any known instances of people running AI's for long periods of time in men? What are the long term side effects?
How long would you recommend running it?
Why isn't it used more commonly? Am I probably just an anomaly with high E2?
I have some clomid on hand too, is it possible to run it alongside letrozole on low doses? Or is it not worth it if i'm already feeling pretty good?

Thanks

[letro]

So no one has any experiencing with solo running AIs?

[booku]

So no one has any experiencing with solo running AIs?

Let me put it this way, basically, yes in theory, an aromatase inhibtor will SLIGHTLY raise endogenous testosterone production because T always follows E. When the testosterone molecule enters your cells through the plasma membrane, there is an enzyme called the aromatase enzyme that binds with testosterone, the signaling molecule in this case. So when you introduce a competitive inhibitor such as letrozole, the letrozole molecule enters the cells just like test and binds to that aromatase enzyme, preventing the test from being converted to estrogen. But, as you can see, there is no change in the AMOUNT of T present in your bloodstream produced by the testicles. So when someone starts talking about solely using an AI as treatment for TRT, yes it will raise test by a significant amount, but not nearly enough if you are testosterone deficient and actually have an underlying medical issue or age related androgen deficiency causing the low T. So it is simply a risk/benefit ratio that 9/10 times is not worth pursuing for people that legitimately have low testosterone.





Pharmacokinetics and dose finding of... [J Clin Endocrinol Metab. 2003] - PubMed - NCBI