My doc usually supplies me with 25x1 but this last time he have me 25x5/8. I emailed him and voiced my concern about not getting deep enough even though quads are lean. He said even with high bf and only getting in subcutaneously is fine. I know you can do either but what's the differance if any? When I cycle larger amounts of compounds I use 25x1 to make sure to get into muscle but small trt amounts I'm not sure if it actually matters all that much?