The enzyme aromatase is responsible for the conversion of androstenedione to estrone and of testosterone to estradiol.
Nolvadex/Clomid can be classified as an estrogen antagonist.
So what effect should that have on 'us'.
Nolvadex & Clomid are both synthetic estrogens that bind to the estrogen receptor (er) and prevent real estrogen from binding and exerting any negative effects (antagonist).
People who use clomid / nolvadex during a cycle still have increased levels of estrogen, it is just with the use of clomid / nolvadex the estrogen cannot bind to the er.
This is good for those not wishing to suffer from increased estrogen levels while on a cycle. However once you stop the use of these estrogen antagonists your estrogen levels are still high and now these high levels can bind to the er where they can cause a number of unwanted side effects (female pattern fat distribution, gyno, water retention etc).
Rather than to let this happen by using an aromatase inhibitor we can get to the root of the problem and prevent high levels of estrogen from forming in the first place.
Arimidex is by far the best choice, then cytadren and proviron can also be used if the first is too expensive. Personally proviron is a good cheap alternative but seems not to work well for everyone. Cytadren can also be used but with this comes complications.
When running clomid post cycle its always advisable to run either arimidex or proviron along side it. This has also helped people stay a little harder and its claimed to help keep gains while also preventing a rebound effect from elevated estrogen levels had they not been used.
I would recommend people invest and research in arimidex/proviron as much as they invest / research in their actual cycle to save time headache and unwanted problems.
Why settle for nolvadex which only prevents problems while using it when you can prevent problems from being initiated in the first place.
btw I am no chemist, biologist or anything similar so anyone else wishing to add anything I along with others would be very interested.
Peace
[email protected]