Does TRT cause Anemia? I've recently had some issues with my blood work from my annual physical with my Primary. I'm on my third round of blood work due to numbers being off which appears to be Anemia related. Could this be due to my use of Test E, which is only 80mgs per week? I've had elevated Hema/RBC in the past, could this be a result of that or even the 60 day donations to keep that under control? My primary is aware of my TRT as I was being treated by him before he referred me to an Endo. The only issues I've had with my TRT related Blood work from my Endo were the elevated Hema/RBC, which I seem to have under control. Also, lately I noticed I have been fatigued and get winded easy.