
Originally Posted by
numbere
Expanding on NACH3s point, ARs upregulate after exposure to increased androgens.
This is one reason it's foolish to use large amounts of AAS only after a few years of cycling.
So to answer your questions, 1.5 g EW for eight weeks will not downregulate one's receptors and 100-150 mg/week would be a sufficient TRT dose.
When one considers using large amounts of AAS they should be aware that side effects will be proportional to dose, but not results.
Just because one has cycled successfully with 0.75 mg of test does not necessarily mean the will see increased results from 1.5g. However, they will see increased side effects.