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Again, I live in Canada. So I can't just privately pay for my own lab tests. Makes things more difficult.
Ok, heard that as well. I don't think they even offer and E2 Sens Assay anyway.
So my questions. I really don't understand how clomid monotherapy works. Clomid blocks estrogen receptors in the brain stopping the inhibitory effects that estrogen has on the brain in regards to the feedback loop for testosterone. It also blocks estrogen at other areas of the body (like breast tissue hence its treatment for gyno) but also acts as estrogen in other areas (like bone). However, I don't understand how once you remove the clomid, how your T levels remain elevated. With the increase in estrogen, wouldn't the super high levels just inhibit the HPTA axis again and cause a low FSH/LH which will in turn lower test back down. I guess this is why I thought an AI was critical to stop the excess rise in estrogen, so that when you remove everything, your low E2 will keep promoting test production until your body rebalances itself??
Can you confirm the science behind clomid monotherapy? Also in most PCT, guys say you don't need an AI??? Yet again with my understanding I don't get how SERMS maintain a high test level after cessation with skyhigh estrogen levels.
Instead of me explaining it:
https://www.ncbi.nlm.nih.gov/pubmed/22044663
Jeffrey Dach is one of the top docs re clomid:
Clomid for Men with Low Testosterone Part One by Jeffrey Dach MD
Clomid For Men with Low Testosterone Part Two by Jeffrey Dach MD
Simply put though your brain thinks there's no estrogen so it ramps up T production to increase E production.
The HCG, I wanted to take prior to the PCT because I feel the months of low test has caused my balls to get smaller. I wanted to restore the leydig cell function pre-SERM to give the best envrionment for test production.?
Can't disagree with that logic. Short term use won't be that suppressive to your hpta.
Kelkel. Could you please explain the science of PCT to me? I have read and read and read, but I still don't understand why an AI is not required for a PCT however most protocols have it optional. Who does an AI benefit and who does it not benefit? Also, I have read the clomid and tamoxifen together is recommended because they are synergistic or work better together? Can you comment.
I guess I am confusedhow after SERM cessation, why very high estrogen levels don't down regulate the HPTA again.
http://forums.steroid.com/anabolic-s...ml#post6666415
Thanks man. All advice is super appreciated. 1 week until my urologist followup and I am most likely going to start something.