Testosterone high dose impact on D1/D2 dopamine receptors

[Slacker78]

Hello guys, i guess this is not a new one, but i would like discuss with you about the well-known issue as the effect of Test on dopamine receptors. I report this experiment, even though it was performed on rats as starting point:

https://www.ncbi.nlm.nih.gov/pubmed/29242988

I've read out there in various articles on the net about testosterone downregulation on D1/D2 dopamine receptors, in long term administration ( TRT/Cruising included ) .
Furthermore, it would explains the frequent depression state many AAS users experiment when they return to TRT/Cruising Test dose, after cycling and/or in extended AAS cycles in time. Some told about a irreversibility state about D1/D2 receptors downregulation or at least a long time before they could return fully-recovered and functional.

It would be great to know your opinion it about and if there are some good tips to avoid this issue in time ( even in TRT as it seems an issue happening even in it, as the exogenous test level are more stable than endogenous one fluctuations.. ).

Any comment will be appreciated.

[fiddlesticks]

I dont believe there's a single study to date that really can answer this question since they all contradict eachother in some way most of the time, there was a good one that basically showed test increased dopamine activity overall but as far as regulation goes its pretty obvious once you come off the receptors are still there but you just don't have the agonism. More test you take to an extent better you will feel but i do not believe dopamine is the primary meditator but endorphins i believe are.

My educated guess would be that no, it doesn't cause downregulation per se but coming off results in you needing more of a stimulus to feel good. Rich Piana said something pretty great that is really easy to remember and apply to this, every positive you get from a drug causes an equal negative.. So once you come off expect a direct opposite of how you felt on, that is just part of this thing.

However, nandrolone-type drugs have been shown to have very negative effects on neurochemicals.

If you want to feel good (productive) as possible IMO it would be ghrps, TRT and T3.

[KennyJ]

I would like to hear what GH would have to say on this topic

[Slacker78]

I dont believe there's a single study to date that really can answer this question since they all contradict eachother in some way most of the time, there was a good one that basically showed test increased dopamine activity overall but as far as regulation goes its pretty obvious once you come off the receptors are still there but you just don't have the agonism. More test you take to an extent better you will feel but i do not believe dopamine is the primary meditator but endorphins i believe are.

My educated guess would be that no, it doesn't cause downregulation per se but coming off results in you needing more of a stimulus to feel good. Rich Piana said something pretty great that is really easy to remember and apply to this, every positive you get from a drug causes an equal negative.. So once you come off expect a direct opposite of how you felt on, that is just part of this thing.

However, nandrolone-type drugs have been shown to have very negative effects on neurochemicals.

If you want to feel good (productive) as possible IMO it would be ghrps, TRT and T3.

Yes, FiddleSticks. Test or Nandrolone it's not so relevant, because if AAS use in general, in long term could cause heavy and irreversibile damage to the brain, this should be a conseguence to do not underestimate. Dopamine and serotonin chemicals are fundamentals for health and living. So if the risk is so real and evident, it would be good to know how to limit it and turning around to lowering the rate.

[Ephemeral]

However, nandrolone-type drugs have been shown to have very negative effects on neurochemicals.

Could you elaborate on that? Are there studies with human subjects?

[fiddlesticks]

Could you elaborate on that? Are there studies with human subjects?

I recall a study showing trenbolone making serotonin based drugs require 700 percent of the usual dosage to release serotonin. Ouch...

Deca is notorious for prolactin problems and its pretty well known why that would cause lethargy, depression, etc. Combine high prolactin with deca weight gain and you have a recipe for feeling like shit.

[The God Himself]

I am very interested in this topic since I am suffering from depression at the moment.

[fiddlesticks]

Yes, FiddleSticks. Test or Nandrolone it's not so relevant, because if AAS use in general, in long term could cause heavy and irreversibile damage to the brain, this should be a conseguence to do not underestimate. Dopamine and serotonin chemicals are fundamentals for health and living. So if the risk is so real and evident, it would be good to know how to limit it and turning around to lowering the rate.

The logical thing would to never take anything above TRT if you would be concerned about that but as someone who knows a little about medical stuff my educated guess is long term test blasting wouldn't cause any permanent brain"damage". In fact I would argue it could be neuroprotective. Fuck tren and deca though, that is just no bueno.

What is funny is basically all PEDs that are not steroids (although id say test and a few others are potentially good) are VERY neuroprotective e.g DNP , insulin, gh, t3, clen igf caffeine. All those substances increase activity of endorphins, BDNF, catecholamines etc.

So in a hilarious twist, one could assume ronnie Coleman or jay Cutler are basically geniuses. The "dumb meathead" stereotype is actually a polar opposite of reality.

[KennyJ]

I am very interested in this topic since I am suffering from depression at the moment.

I'm very interested in this as well because I have pretty much made up my mind to go on TRT after the cycle I'm on now. Do you stay on year round?

[Slacker78]

I'm very interested in this as well because I have pretty much made up my mind to go on TRT after the cycle I'm on now. Do you stay on year round?

It could be something that interferes with dopamine system. A diriment trying could be to assume a lower dose of Caber and see if something run better.

[EDCG19]

My educated guess would be that no, it doesn't cause downregulation per se but coming off results in you needing more of a stimulus to feel good. Rich Piana said something pretty great that is really easy to remember and apply to this, every positive you get from a drug causes an equal negative.. So once you come off expect a direct opposite of how you felt on, that is just part of this thing.

This does make sense but how long would it take to feel normal again on lower doses or is this something that never comes back and you'll only feel great at those higher doses?

[fiddlesticks]

This does make sense but how long would it take to feel normal again on lower doses or is this something that never comes back and you'll only feel great at those higher doses?

At this point from personal experience what I can say is feeling " normal " is very, very shitty if you've ever been at the top so its almost impossible to answer. Its like being in a different realm than the people who live "normal" life without drugs, those people can feel "good" from absolutely tiny things where someone who is used to being on test, insulin etc just has a much higher standard of life. These things are nearly impossible to explain and definitely need to be experienced first-hand, just dont use ridiculous doses

[EDCG19]

At this point from personal experience what I can say is feeling " normal " is very, very shitty if you've ever been at the top so its almost impossible to answer. Its like being in a different realm than the people who live "normal" life without drugs.

I'm having trouble understanding what you mean by this
Do you mean running higher doses will make you feel like shit or you'll never feel normal again? I'm having trouble understand here.. what do you mean?

[fiddlesticks]

I'm having trouble understanding what you mean by this
Do you mean running higher doses will make you feel like shit or you'll never feel normal again? I'm having trouble understand here.. what do you mean?

You will feel amazing while on high test.

You will feel like joe average off cycle/low trt.

Your perception of reward is still the same as it was on 500 test as it is on 100, whatever dopamine receptor opiod serotonin receptor up down regulation happens is secondary to your particular lifestyle. But you will always feel amazing taking higher test bottom line. (500 - 750, past that i would expect only side effects. )

[GearHeaded]

from my own personal experience - I think that newer users are generally the guys that feel amazing while on cycle or blasting higher dosages of test. for guys that have experimented for years it doesn't work that way anymore for the most part.

kinda like the idea that when people start smoking weed for the first few times they get the "giggles" . but after awhile it no longer has that effect.

the feeling of being on cycle is somewhat of a burden to me. its not like years past that I'd feel on top of the world from running a measly 500mg of test. I actually go into a cycle knowing that I'm going to end up feeling like shit, lethargic, burnt out, unable to sleep, restless, anxiety, etc. and the only time I'll feel like a normal person is in the gym.
I'm running 2000mg of test a week right now and have done so numerous times. I feel far from amazing (the gram of tren a week obviously isn't helping either).

the times I feel best are when I'm just cruising on like 200mg of test and 400mg of Primo. it feels like I'm NOT even on anything at all. feeling like I'm not on any gear is actually what feeling good feels like now days (years back I used to seek and want to feel like I was on cycle).
Feeling good is feeling like I'm off cycle. Being on cycle is not comfortable . if it wasn't for me trying to put on slabs of muscle and was only about how I mentally felt (excluding anything to do with the gym), then I'd simply run 250mg of test and leave it at that.
more test doesn't make me feel better at all . it just makes me grow better and perform better in the gym , but for the 22 hours a day I'm not in the gym I don't really feel all that great on high dosages of test.

for guys that say "I feel like a god on tren" . thats a dead give away that that guy is very inexperienced and only ran a few cycles.
for you guys that have ran a few dozen or more cycles or been experimenting with AAS for years , you know what I'm talking about. Being on a heavy cycle is quite uncomfortable and you go into the cycle knowing thats how your going to feel, the idea of feeling "amazing'' doesn't even cross your mind .. you go into it knowing its going to be a grind.

thats just my own thoughts based on my own experience. I've done zero actual formal research on the topic at hand so only feel I can speak to my own experiences


note: there are some exceptions to this . if I run low dosages of Dbol with TRT I feel great.. running Primo with TRT I feel great. but running an actual 'hard core' heavy cycle that will make me grow is going to be very uncomfortable.


maybe my dopamine receptors are fried and high dosages of test do nothing for me any more . idk

[KennyJ]

from my own personal experience - I think that newer users are generally the guys that feel amazing while on cycle or blasting higher dosages of test. for guys that have experimented for years it doesn't work that way anymore for the most part.

kinda like the idea that when people start smoking weed for the first few times they get the "giggles" . but after awhile it no longer has that effect.

the feeling of being on cycle is somewhat of a burden to me. its not like years past that I'd feel on top of the world from running a measly 500mg of test. I actually go into a cycle knowing that I'm going to end up feeling like shit, lethargic, burnt out, unable to sleep, restless, anxiety, etc. and the only time I'll feel like a normal person is in the gym.
I'm running 2000mg of test a week right now and have done so numerous times. I feel far from amazing (the gram of tren a week obviously isn't helping either).

the times I feel best are when I'm just cruising on like 200mg of test and 400mg of Primo. it feels like I'm NOT even on anything at all. feeling like I'm not on any gear is actually what feeling good feels like now days (years back I used to seek and want to feel like I was on cycle).
Feeling good is feeling like I'm off cycle. Being on cycle is not comfortable . if it wasn't for me trying to put on slabs of muscle and was only about how I mentally felt (excluding anything to do with the gym), then I'd simply run 250mg of test and leave it at that.
more test doesn't make me feel better at all . it just makes me grow better and perform better in the gym , but for the 22 hours a day I'm not in the gym I don't really feel all that great on high dosages of test.

for guys that say "I feel like a god on tren" . thats a dead give away that that guy is very inexperienced and only ran a few cycles.
for you guys that have ran a few dozen or more cycles or been experimenting with AAS for years , you know what I'm talking about. Being on a heavy cycle is quite uncomfortable and you go into the cycle knowing thats how your going to feel, the idea of feeling "amazing'' doesn't even cross your mind .. you go into it knowing its going to be a grind.

thats just my own thoughts based on my own experience. I've done zero actual formal research on the topic at hand so only feel I can speak to my own experiences


note: there are some exceptions to this . if I run low dosages of Dbol with TRT I feel great.. running Primo with TRT I feel great. but running an actual 'hard core' heavy cycle that will make me grow is going to be very uncomfortable.


maybe my dopamine receptors are fried and high dosages of test do nothing for me any more . idk

Thanks for sharing your personal experiences. If you recall our discussion on the hormonal sides I am feeling from all the elevated androgens(anxiety, CNS issues etc) is that kind of what happens to you when you run your very advanced cycles or is it a totally different reason you feel bad when on cycle?

[Slacker78]

I remember a documentary on cocaine long term issues. People who told their experiences, they told when tried to come off from cocaine, that life around them seemed empty without any meaning. They described themselves as it was nothing be able to give them emotions. Experts explained this with dopamine receptors destruction caused by cocaine abuse in years. They had need to come back to use cocaine again to "activate" those receptors. Experts told that a consistent part of dopamine receptors wouldn't be regenerated in years, so the damage would be permanent. There are a ton of evidences about this out there. Regard to AAS long term use, i don't know if the same process happen to dopamine/serotonin receptors, neither how much the impact is on them. Is logical to think that in TRT, as this is not supraphysiological test dose, this issue should be excluded or to do not impact in the same way it could on supraphysiological AAS cycle. I've read about Deprenyl ( Selegiline ) drug which could be a potential shield against this issue and not only for AAS users...

[Slacker78]

I've read another thread which could have some affinity with this thread https://forums.steroid.com/anabolic-...ain-cells.html

[Testlolblast]

And what could happen if you inject 8,8 g of testosterone enanthate at once?

I don't wanna be missunderstood I'm asking just for substance for reflection from knowledgeable people, of course!

[Chrisp83TRT]

I remember a documentary on cocaine long term issues. People who told their experiences, they told when tried to come off from cocaine, that life around them seemed empty without any meaning. They described themselves as it was nothing be able to give them emotions. Experts explained this with dopamine receptors destruction caused by cocaine abuse in years. They had need to come back to use cocaine again to "activate" those receptors. Experts told that a consistent part of dopamine receptors wouldn't be regenerated in years, so the damage would be permanent. There are a ton of evidences about this out there. Regard to AAS long term use, i don't know if the same process happen to dopamine/serotonin receptors, neither how much the impact is on them. Is logical to think that in TRT, as this is not supraphysiological test dose, this issue should be excluded or to do not impact in the same way it could on supraphysiological AAS cycle. I've read about Deprenyl ( Selegiline ) drug which could be a potential shield against this issue and not only for AAS users...

All I can say is this ...

Becareful how much you read and research.

It will make you crazy bro.
Yes the web is a place to learn a shit ton and expand the brain , but alot of information can be simple opinions and like someone else said, contradictory to another article .

Be mindful of your mind and enjoy life.

Everything in life is a choice and every choice will have its pros and cons.

Be happy in the moment and make sure you are being safe and kind to yourself.

You are literally going to drive yourself crazy on this shit.

Personally , I don't think test effects the brains at all if used for a long period of time.
It's not coke
It's something our bodies make.

Yes we are putting foreign test in our body but I highly doubt it will effect your brain or receptors .

I know what its like to go ape shit researching and I can tell you , I end up feeling worse than I did before.

So just take your test and be a beast in gym.
Kiss your girl when you see her , tell your family you love them and just smile.

Believe me , you're fine lol

Sent from my JSN-AL00 using Tapatalk

[Slacker78]

All I can say is this ...

Becareful how much you read and research.

It will make you crazy bro.
Yes the web is a place to learn a shit ton and expand the brain , but alot of information can be simple opinions and like someone else said, contradictory to another article .

Be mindful of your mind and enjoy life.

Everything in life is a choice and every choice will have its pros and cons.

Be happy in the moment and make sure you are being safe and kind to yourself.

You are literally going to drive yourself crazy on this shit.

Personally , I don't think test effects the brains at all if used for a long period of time.
It's not coke
It's something our bodies make.

Yes we are putting foreign test in our body but I highly doubt it will effect your brain or receptors .

I know what its like to go ape shit researching and I can tell you , I end up feeling worse than I did before.

So just take your test and be a beast in gym.
Kiss your girl when you see her , tell your family you love them and just smile.

Believe me , you're fine lol

Sent from my JSN-AL00 using Tapatalk

My friend, i'm agree with you, but an intelligent approch to knowledge is worth and a must in every fields. I analyze the literature and research in its general complex; "personally" opinions are worth but too much little to receive reliability. Nothing against of you of course, i've appreciated your comment

[Test Monsterone]

I finished my first cycle last month. Three months on, felt fine overall. Now one month into self prescribed TRT and I am very irritable at times. I wake up angry a lot. I want to punch shit and I’m using a lot more green to calm myself.

There are a lot of variables at play though. I stopped working out for a month to give my body time to repair itself. Too many joint and tendon pains. It’s cold and crappy out and I don’t get enough sun. I’m eating like crap and I’m trying to find a house so I’m stressed out. Have been working longer than usual.

So yeah, I think it’s a combination of things, but definitely feel different than when on cycle. Although, like I said, don’t on was t anything special, I just felt normal.

[KennyJ]

I finished my first cycle last month. Three months on, felt fine overall. Now one month into self prescribed TRT and I am very irritable at times. I wake up angry a lot. I want to punch shit and I’m using a lot more green to calm myself.

There are a lot of variables at play though. I stopped working out for a month to give my body time to repair itself. Too many joint and tendon pains. It’s cold and crappy out and I don’t get enough sun. I’m eating like crap and I’m trying to find a house so I’m stressed out. Have been working longer than usual.

So yeah, I think it’s a combination of things, but definitely feel different than when on cycle. Although, like I said, don’t on was t anything special, I just felt normal.

What did you run during your cycle?
How many cycles have you done?
How long have you been doing TRT?
What were your testosterone levels during cycle?

[Test Monsterone]

What did you run during your cycle?
How many cycles have you done?
How long have you been doing TRT?
What were your testosterone levels during cycle?

Just one cycle, test C and then test E and prop. Started at a low trt dose then decided to cycle. Went up to 800 mg. Now on trt test e at 175 mg approx. I’m always a miserable fuck though so who knows.

[KennyJ]

Just one cycle, test C and then test E and prop. Started at a low trt dose then decided to cycle. Went up to 800 mg. Now on trt test e at 175 mg approx. I’m always a miserable fuck though so who knows.

It sounds like some hormonal issues. If you're needing the TRT I would definitely get some blood work ASAP and find a doc to legitimately put you on it. That way you can look at bloodwork as you go and figure out what needs adjusting.

[fiddlesticks]

Just one cycle, test C and then test E and prop. Started at a low trt dose then decided to cycle. Went up to 800 mg. Now on trt test e at 175 mg approx. I’m always a miserable fuck though so who knows.

I would wager low t3. Have you ever used t3?

[fiddlesticks]

My friend, i'm agree with you, but an intelligent approch to knowledge is worth and a must in every fields. I analyze the literature and research in its general complex; "personally" opinions are worth but too much little to receive reliability. Nothing against of you of course, i've appreciated your comment

I too, have analysed ALL this shit, like over the past 3 years the amount of time I have spent learning about all this stuff (neurological stuff, not really peds) is horrifying and i regret it. Life is harder to enjoy when you understand neurochemistry tbh. Probably gonna wanna just stop researching it before you go insane.

[Chrisp83TRT]

I too, have analysed ALL this shit, like over the past 3 years the amount of time I have spent learning about all this stuff (neurological stuff, not really peds) is horrifying and i regret it. Life is harder to enjoy when you understand neurochemistry tbh. Probably gonna wanna just stop researching it before you go insane.

In some cases ignorance is bliss.


I remember one time iwas having stomach issues and I was researching what it might be.
I wound up crying that day thinking I had terrible things

Sometimes it's best to just leave it alone and know the basics.

Knowledge is great but if you can't handle certain things , it's best to not dig any deeper.

Sent from my JSN-AL00 using Tapatalk

[KennyJ]

In some cases ignorance is bliss.


I remember one time iwas having stomach issues and I was researching what it might be.
I wound up crying that day thinking I had terrible things

Sometimes it's best to just leave it alone and know the basics.

Knowledge is great but if you can't handle certain things , it's best to not dig any deeper.

Sent from my JSN-AL00 using Tapatalk

Google has scared the crap outta me several times

[Slacker78]

Just one cycle, test C and then test E and prop. Started at a low trt dose then decided to cycle. Went up to 800 mg. Now on trt test e at 175 mg approx. I’m always a miserable fuck though so who knows.

You should check E2 and SHBG. Get a complete blood work.

Yes, i'm agree ignorance sometimes is a bliss. But it's a fact AAS upregulates androgens receptors which in turn modulate dopamine, serotonin, GABA receptors. When a certain amount of androgens decrease ( you got off cycle ) these receptors "see" androgens deficiency. It was like andropause. This leads to all symptoms we are talking about.

[The God Himself]

Sometimes you'll feel like its not worth living anymore, but then you realize and explain yourself that you can't die because you still have to run a few cycles.
If I die at this point, my corpse won't be as muscular as it is supposed to be. So why not run another tren cycle?

[Slacker78]

Sometimes you'll feel like its not worth living anymore, but then you realize and explain yourself that you can't die because you still have to run a few cycles.
If I die at this point, my corpse won't be as muscular as it is supposed to be. So why not run another tren cycle?

LOL..

[fiddlesticks]

As someone who is prescribed amphetamines (dopamine releasing drug) the feeling of "low dopamine" after the drug fades off is devastating and doesn't last very long, no steroid I've ever used has had a negative effect of that magnitude nor do I think they can, not even tren (but that would be close with how it targets prolactin)

Basically I'm trying to say we can experience any emotion at any given time and it doesn't exactly mean XYZ is up or downregulated

[Chrisp83TRT]

As someone who is prescribed amphetamines (dopamine releasing drug) the feeling of "low dopamine" after the drug fades off is devastating and doesn't last very long, no steroid I've ever used has had a negative effect of that magnitude nor do I think they can, not even tren (but that would be close with how it targets prolactin)

Basically I'm trying to say we can experience any emotion at any given time and it doesn't exactly mean XYZ is up or downregulated

I agree.

Yes you won't feel like at your best but your body will regulate again.
That's why they say doing cycles is a choice lol.

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[fiddlesticks]

I agree.

Yes you won't feel like at your best but your body will regulate again.
That's why they say doing cycles is a choice lol.

Sent from my JSN-AL00 using Tapatalk

Exactly, it's extremely easy to confuse "normal" with "i feel bad cuz im not as big as I was" and then thinking all your neurotransmitters are gone when in reality you are only upset due to physique changes.

[Slacker78]

Yes, i'm perfectly agree with both. The problem would be if it was reversible or not after AAS suspension/dosage reduction. I think that the emergent best practice, is to do very shorter cycles as possibile and come off back in TRT for a while and after blasting again keeping the same time frame schema ( related to esters used ). Long/short term AAS use/abuse is the gold variable in this case.

[KennyJ]

Yes, i'm perfectly agree with both. The problem would be if it was reversible or not after AAS suspension/dosage reduction. I think that the emergent best practice, is to do very shorter cycles as possibile and come off back in TRT for a while and after blasting again keeping the same time frame schema ( related to esters used ). Long/short term AAS use/abuse is the gold variable in this case.

First off I'm not saying that the following statements will be the same as coming off AAS but:
I can say as a former drug addict that yes when you quit certain things you feel as if you will never feel good again, but when you fight through this you will slowly start to feel better and one day you will all of a sudden realize "man I'm feeling good" and you will have up and down days but you will reach a point where it gets better progressively every week. A type of fog will lift and suppressed senses and feelings will come back. It will feel as if your body is waking up and the cobwebs will disappear and you can begin living a great life again. I could go into this deeper but maybe this will help someone.

[The God Himself]

First off I'm not saying that the following statements will be the same as coming off AAS but:
I can say as a former drug addict that yes when you quit certain things you feel as if you will never feel good again, but when you fight through this you will slowly start to feel better and one day you will all of a sudden realize "man I'm feeling good" and you will have up and down days but you will reach a point where it gets better progressively every week. A type of fog will lift and suppressed senses and feelings will come back. It will feel as if your body is waking up and the cobwebs will disappear and you can begin living a great life again. I could go into this deeper but maybe this will help someone.

Sure, I've been into this as well.
You can feel like happiness is not possible anymore. You ask yourself, how these people are able to smile? You just feel like shit and depressed for no reason, there is a heaviness on your chess and millions of people are throttling, squeezing your neck.. You can't swallow.
Good news, don't stop fighting. Time is the most efficient drug of all time, although not FDA approved yet. As time passes, you start to feel better like KennyJ said. And you start to ask yourself, how did I manage to feel that depressed, was that real?
Getting psychotherapy and talking to someone, sharing your inner world helps a lot.

[KennyJ]

Sure, I've been into this as well.
You can feel like happiness is not possible anymore. You ask yourself, how these people are able to smile? You just feel like shit and depressed for no reason, there is a heaviness on your chess and millions of people are throttling, squeezing your neck.. You can't swallow.
Good news, don't stop fighting. Time is the most efficient drug of all time, although not FDA approved yet. As time passes, you start to feel better like KennyJ said. And you start to ask yourself, how did I manage to feel that depressed, was that real?
Getting psychotherapy and talking to someone, sharing your inner world helps a lot.

TGH, I remember you saying you weren't feeling that well a few days ago. Have you started feeling better. I hope so!

[KennyJ]

from my own personal experience - I think that newer users are generally the guys that feel amazing while on cycle or blasting higher dosages of test. for guys that have experimented for years it doesn't work that way anymore for the most part.

kinda like the idea that when people start smoking weed for the first few times they get the "giggles" . but after awhile it no longer has that effect.

the feeling of being on cycle is somewhat of a burden to me. its not like years past that I'd feel on top of the world from running a measly 500mg of test. I actually go into a cycle knowing that I'm going to end up feeling like shit, lethargic, burnt out, unable to sleep, restless, anxiety, etc. and the only time I'll feel like a normal person is in the gym.
I'm running 2000mg of test a week right now and have done so numerous times. I feel far from amazing (the gram of tren a week obviously isn't helping either).

the times I feel best are when I'm just cruising on like 200mg of test and 400mg of Primo. it feels like I'm NOT even on anything at all. feeling like I'm not on any gear is actually what feeling good feels like now days (years back I used to seek and want to feel like I was on cycle).
Feeling good is feeling like I'm off cycle. Being on cycle is not comfortable . if it wasn't for me trying to put on slabs of muscle and was only about how I mentally felt (excluding anything to do with the gym), then I'd simply run 250mg of test and leave it at that.
more test doesn't make me feel better at all . it just makes me grow better and perform better in the gym , but for the 22 hours a day I'm not in the gym I don't really feel all that great on high dosages of test.

for guys that say "I feel like a god on tren" . thats a dead give away that that guy is very inexperienced and only ran a few cycles.
for you guys that have ran a few dozen or more cycles or been experimenting with AAS for years , you know what I'm talking about. Being on a heavy cycle is quite uncomfortable and you go into the cycle knowing thats how your going to feel, the idea of feeling "amazing'' doesn't even cross your mind .. you go into it knowing its going to be a grind.

thats just my own thoughts based on my own experience. I've done zero actual formal research on the topic at hand so only feel I can speak to my own experiences


note: there are some exceptions to this . if I run low dosages of Dbol with TRT I feel great.. running Primo with TRT I feel great. but running an actual 'hard core' heavy cycle that will make me grow is going to be very uncomfortable.


maybe my dopamine receptors are fried and high dosages of test do nothing for me any more . idk

There should definitely be an asterisk beside GH and Obs name on every post for any new members that says do not try this shit at home or this information is for advanced users only lol. Just kidding around, hope both of you guys are doing well.