Breast enlargement pill since 1970's

[Fluidic Kimbo]

A drug called 'D-penicillamine' was prescribed to patients in the 1970's to treat arthritis.

An unintended side effect was severe growth of the breasts. I'm not talking a cup size or two, more like breast gigantism.

You can find the full document here:

https://www.ncbi.nlm.nih.gov/pmc/art...0643-0028b.pdf

Here's a few excerpts:

In January 1976 a 41-year-old nulliparous woman who suffered from
rheumatoid arthritis began taking D-penicillamine 750 mg daily. In July
1977 she began to complain of breast enlargement. In June 1978 she discontinued the D-penicillamine for three weeks. There was no reduction in
the size of her breasts and she had severe swelling of both knees. The D-
penicillamine was restarted. In October 1978, after a further slight increase
in the size of her breasts, the D-penicillamine was discontinued. Treatment
with indomethacin was started and in January 1979 was changed to naproxen
250 mg three times a day. In February 1979, five months after the last
exposure to D-penicillamine, the patient was admitted to hospital with severe breast enlargement. She refused surgery.

And furthermore:

How D-penicillamine induces breast enlargement is ill understood. An effect on sex hormone binding globulin might increase the amount
of circulating free oestrogen.' Had D-penicillamine interfered with oestrogen binding the effects should have been apparent in other
oestrogen-dependent tissues. The patient did not show changes in menstrual function while receiving D-penicillamine, nor during the time of maximal breast growth. It is more likely that D-penicillamine produced a local effect on the breast.

I don't know if they've explored further into how this drug works, but if they can turn it into a safe pill treatment then it will be sought after by at least a billion of the 2.5 billion adult women in the world.

[Fluidic Kimbo]

Surprised more research hasn't been done on this.

[lovbyts]

Surprised more research hasn't been done on this.

Maybe this is why. "Only one case of gigantomastia due to bucillamine, an analogue of D-penicillamine, has been reported so far."

[Fluidic Kimbo]

Four cases:

(1985) Massive Breast Enlargement in Systemic Sclerosis Patient : A woman undergoing D-penicillamine treatment for systemic sclerosis developed significant breast enlargement, which regressed after discontinuing the medication.

(2002) Breast Enlargement in Scleroderma Patient : A 55-year-old woman receiving D-penicillamine for scleroderma experienced breast enlargement that subsided upon stopping the drug.

(2004) Breast Gigantism in Wilson's Disease Patient : A 22-year-old woman treated with D-penicillamine for Wilson's disease noticed gradual enlargement of both breasts over ten months.

(2006) Breast Gigantism in Wilson's Disease Patient: A 19-year-old female with Wilson's disease developed diffuse enlargement of both breasts during penicillamine therapy.


If I was Elon Musk, here's what I'd do:

Put all the space stuff on hold for a while. Find the people who developed the Melanotan peptide, and build a new state of the art laboratory for them. Tell them that they need to make hundreds of molecules similar to D-penicillamine and test them on breasts.

If they hit the jackpot and find something as effective as Melanotan (i.e. it works for 100% of people with no reported deaths) but for enlargening breasts, it will change the world.