Retatrutide, MOTS-c & SLU-PP-332 ? A Bodybuilder?s Take on Running the Stack With TRT

[RON]

So from a bodybuilding point of view, the big challenge during any recomposition phase is dropping fat fast without sacrificing muscle or strength. Usually we rely on eating clean, a deficit, cardio, good programming, and TRT to hold onto lean mass. But now you've got this new wave of metabolic peptides that people are talking about using as an "enhanced recomp stack."

The three that keep coming up are:

* Retatrutide - triple agonist, insane fat-loss potential
* MOTS-c - mitochondrial peptide that boosts fat oxidation and insulin sensitivity
* SLU-PP-332 - ERR agonist, basically an "exercise-mimetic" that increases mitochondrial output

When you look at how these work, especially in combination with TRT, you can see why lifters are interested. Here's the breakdown from a bodybuilding perspective.
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Retatrutide - The Nuclear Cutting Tool

Retatrutide is easily the most powerful fat-loss agent in trials right now. For a bodybuilder, the appeal is obvious:
* Cripples appetite
* Makes deep deficits easy
* Produces very fast fat loss
* Helps control blood sugar
* Has some energy-expenditure increase due to glucagon activity

Downside:
GI issues like other GLP-1s, lower training energy if you starve yourself, and potential muscle loss without support (TRT, protein, training).

This is where MOTS-c and SLU-PP-332 come in.
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MOTS-c - The Fat Utilization / Muscle-Support Peptide

MOTS-c is interesting for bodybuilders because it improves how the body uses fuel.

* Increases fat oxidation
* Improves insulin sensitivity
* Helps nutrient partitioning
* May protect muscle tissue in a deficit
* Can improve endurance and work capacity

With Retatrutide pulling calories way down, MOTS-c acts like an engine-tuner that makes the body burn fat more efficiently while sparing muscle.
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SLU-PP-332 - The Exercise-Mimetic

SLU-PP-332 activates ERR pathways, the same ones stimulated during endurance training.

In bodybuilding terms, that means:

* Increased mitochondrial output
* Better endurance
* Higher daily energy burn
* Improved recovery
* "Cardio without more cardio"

This matters when Retatrutide has you eating very little. SLU-PP-332 can help keep performance up so you don't lose strength or flatten out too badly.
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TRT + The Stack = Theoretical Synergy

TRT stabilizes hormones and helps preserve muscle:

* Better recovery
* Stronger nitrogen balance
* More strength retention
* Improved mood and drive

Combine that with the three metabolic agents and, on paper, you get a very potent physique-recomp environment.
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Synergy Breakdown

Retatrutide + MOTS-c
* Retatrutide creates the deficit
* MOTS-c pushes the body to burn fat instead of muscle
→ Cleaner, faster fat loss

Retatrutide + SLU-PP-332
* Retatrutide kills appetite
* SLU-PP-332 helps maintain performance
→ Strength and gym intensity stay higher even while dieting

MOTS-c + SLU-PP-332
* Both improve mitochondrial efficiency
→ More energy, better cardio, more endurance

TRT + All Three
* TRT protects muscle
* Retatrutide slashes fat
* MOTS-c improves nutrient partitioning
* SLU-PP-332 boosts performance
→ Basically a contest-prep-like environment with less suffering (in theory).
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Expected Bodybuilder Results (If Everything Works Right)

* Rapid fat loss
* Better nutrient partitioning
* Higher endurance and better cardio
* Less "flatness" compared to a normal aggressive cut
* Steadier blood sugar and fewer cravings
* More muscle retention during the deficit
* Improved conditioning as fat comes off

Physique changes typically noticed:
* Midsection/lower back thinning out
* Energy staying higher than expected
* Pumps staying decent despite low calories
* Strength dropping slower than expected
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Hypothetical Protocol Style (For Discussion Only)

(Not recommendations - just describing what lifters talk about.)

Retatrutide:
Weekly injection with slow titration (like clinical trials).

MOTS-c:
Commonly discussed: 10-15 mg, 2-3x weekly.

SLU-PP-332:
Commonly discussed: 20-40 mg/day oral.

TRT:
100-150 mg/wk typical TRT.
Some bump to 150-200 mg on a deep cut for muscle support.

Again: experimental compounds, no human combo data, high risk.
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Risks for Bodybuilders

* Retatrutide can reduce protein intake → muscle loss risk
* SLU-PP-332 is preclinical → unknown cardiac effects
* MOTS-c improves insulin sensitivity → hypoglycemia possible
* Zero human safety data on using all three together
* GI sides lowering training intensity
* Extreme deficits + high training output can crash recovery
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Bottom Line

For bodybuilders on TRT, the theoretical idea behind this stack is:
* Retatrutide melts fat
* MOTS-c improves metabolic efficiency
* SLU-PP-332 maintains performance
* TRT keeps muscle on

Together it could create one of the strongest fat-loss environments imaginable on paper.

But also one of the riskiest because:

* MOTS-c is not clinically established
* SLU-PP-332 is purely preclinical
* The combo has never been studied
* Safety is unknown

[RON]

I made this with AI. It's pretty accurate but I would say dosage for me I think should look like this.

Reta 2mg a week evaluate every 4 weeks and either maintain or double dosage up to 18mg
Mot-C Daily you can start as low as 1mg ED. Taper to 5mg ED
Slu-pp-332 1-2 injections daily. Start with 500 mcg per injection rise up to 1500 mcg per.
MOT-C and SLU will cause you to feel tired so make your dosage accordingly.
Starting my first run of this trifecta new years so this is all just from research. I'll update with my reactions after I run the cycle.

[Booz]

Will be following with interest mate

[RON]

I'll be the guinea pig Booz. I think eventually us old guys will be on Test and Peptides. Less risks. Even the HGH. I have been researching replacing HGH with peps and the risks are mitigated from what I have read. It's on my to do list. I know Vette's been on the peptide journey too.

[Booz]

I?ve been looking into the HGH peptide wise myself..

[RON]

For some reason when I think of peptides in my head I see those bottles of fake steroids in a pill we used to see in the early 2000's. So many people trying to scam all theses years make it hard for me to trust in a real good thing. I will be slowing testing all these myself.

[Booz]

I get that mate all the testosterone boosters 😵*💫😏